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Item number675336
Molecular weight71,08 g/mol
Quantity 1x250mg
storage conditions20 °C
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Safety Data Sheetaccording to Regulation (EC) No 1907/2006 (REACH)
Classifications according to Regulation (EC) No 1272/2008.
Printdate 05.12.2022
Product name:Acrylamide
Catalog No.:675336
Relevant identified uses of the substance or mixtureIdentified: Laboratory chemical
uses: R&D
Uses advised against:HPC Standards GmbH
Am Wieseneck 7

04451 Cunnersdorf

Tel. +49 34291 3372-36
Fax. +49 34291 3372-39
Emergency telephone numberHPC Standards Tel. +49 34291 3372-36
This number is only available during office hours.
HAZARDS IDENTIFICATION2.1 Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008
Carcinogenicity (Category 1B), H350
Germ cell mutagenicity (Category 1B), H340
Reproductive toxicity (Category 2), H361f
Acute toxicity, Oral (Category 3), H301
Specific target organ toxicity - repeated exposure (Category 1), H372
Acute toxicity, Inhalation (Category 4), H332
Acute toxicity, Dermal (Category 4), H312
Eye irritation (Category 2), H319
Skin irritation (Category 2), H315
Skin sensitisation (Category 1), H317 Classification according to EU Directives 67/548/EEC or 1999/45/EC
T Toxic R25, R48/23/24/25
Xn Harmful R20/21
Xi Irritant R36/38
Label elements
PictogramGHS06 skull
GHS08 silhouete
Signal word Danger
Hazard statement(s)
H301 Toxic if swallowed.
H312 + H332 Harmful in contact with skin or if inhaled
H315 Causes skin irritation.
H317 May cause an allergic skin reaction.
H319 Causes serious eye irritation.
H340 May cause genetic defects.
H350 May cause cancer.
H361f Suspected of damaging fertility.
H372 Causes damage to organs through prolonged or repeated exposure.
Precautionary statement(s)
P201 Obtain special instructions before use.
P280 Wear protective gloves/ protective clothing.
P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove
contact lenses, if present and easy to do. Continue rinsing.
P308 + P313 IF exposed or concerned: Get medical advice/ attention.
Supplemental Hazard
Restricted to professional users.
2.3 Other hazards - none
Synonyms : Acrylic acid amide
Formula : C3H5NO
Molecular Weight : 71,08 g/mol
CAS-No. : 79-06-1
EC-No. : 201-173-7
Index-No. : 616-003-00-0
Registration number : 01-2119463260-48-XXXX
Hazardous ingredients according to Regulation (EC) No 1272/2008
Component Classification Concentration
Acrylamide Included in the Candidate List of Substances of Very High Concern (SVHC) according to
Regulation (EC) No. 1907/2006 (REACH)
Registration number
Carc. 1B; Muta. 1B; Repr. 2;
Acute Tox. 3; STOT RE 1;
Acute Tox. 4; Eye Irrit. 2; Skin
Irrit. 2; Skin Sens. 1; H372,
H319, H315, H301, H312,
H317, H332, H340, H350,
<= 100 %
Hazardous ingredients according to Directive 1999/45/EC
Component Classification Concentration Acrylamide Included in the Candidate List of Substances of Very High Concern (SVHC) according to
Regulation (EC) No. 1907/2006 (REACH)
Registration number
T, Carc.Cat.2, Mut.Cat.2,
Repr.Cat.3, R45 - R46 -
R20/21 - R25 - R36/38 - R43 -
R48/23/24/25 - R62
<= 100 %
Molecular Weight (g/mol)71.08
FIRST AID MEASURES4.1 Description of first aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician.
In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in
section 11
4.3 Indication of any immediate medical attention and special treatment needed
no data available
FIRE-FIGHTING MEASURES5.1 Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
5.2 Special hazards arising from the substance or mixture
Carbon oxides, nitrogen oxides (NOx)
5.3 Advice for firefighters
Wear self contained breathing apparatus for fire fighting if necessary.
5.4 Further information
no data available
ACCIDENTAL RELEASE MEASURES6.1 Personal precautions, protective equipment and emergency procedures
Wear respiratory protection. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure
adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust.
For personal protection see section 8.
6.2 Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the
environment must be avoided.
6.3 Methods and materials for containment and cleaning up
Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed
containers for disposal. 6.4 Reference to other sections
For disposal see section 13.
HANDLING AND STORAGE7.1 Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols.Avoid exposure - obtain special
instructions before use.
Provide appropriate exhaust ventilation at places where dust is formed.
For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
Light sensitive. Store under inert gas.
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated
Components with workplace control parameters
8.2 Exposure controls
Appropriate engineering controls
Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling
the product.
Personal protective equipment
Eye/face protection
Face shield and safety glasses Use equipment for eye protection tested and approved under
appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
(without touching glove's outer surface) to avoid skin contact with this product. Dispose of
contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands. Body Protection
Complete suit protecting against chemicals, The type of protective equipment must be selected
according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection
Where risk assessment shows air-purifying respirators are appropriate use a full-face particle
respirator type N100 (US) or type P3 (EN 143) respirator cartridges as a backup to engineering
controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use
respirators and components tested and approved under appropriate government standards such
as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into
the environment must be avoided.
PHYSICAL AND CHEMICAL PROPERTIES9.1 Information on basic physical and chemical properties
a) Appearance Form: solid
b) Odour no data available
c) Odour Threshold no data available
d) pH 5,2 - 6 at 500 g/l
e) Melting point/freezing
Melting point/range: 82 - 86 °C - lit.
f) Initial boiling point and
boiling range
125 °C at 33 hPa - lit.
g) Flash point 138 °C - closed cup
h) Evapouration rate no data available
i) Flammability (solid, gas) no data available
j) Upper/lower
flammability or
explosive limits
no data available
k) Vapour pressure 2,1 hPa at 84,50 °C
0,04 hPa at 40 °C
0,0900 hPa at 25 °C
l) Vapour density 2,45 - (Air = 1.0)
m) Relative density no data available
n) Water solubility 200 g/l at 20 °C
o) Partition coefficient: noctanol/
log Pow: -0,67
p) Auto-ignition
no data available
q) Decomposition
no data available
r) Viscosity no data available
s) Explosive properties no data available
t) Oxidizing properties no data available
9.2 Other safety information
Relative vapour density 2,45 - (Air = 1.0)
no data available
10.2 Chemical stability
Stable under recommended storage conditions.
10.3 Possibility of hazardous reactions
no data available
10.4 Conditions to avoid
no data available
10.5 Incompatible materials
Acids, Oxidizing agents, Iron and iron salts., Copper, Brass, Free radical initiators
10.6 Hazardous decomposition products
Other decomposition products - no data available
In the event of fire: see section 5
TOXICOLOGICAL INFORMATION11.1 Information on toxicological effects
Acute toxicity
LD50 Oral - rat - 177 mg/kg
LC50 Inhalation - rat - 4 h - > 1.500 mg/m3
LD50 Dermal - rabbit - 1.141 mg/kg
(OECD Test Guideline 402)
Skin corrosion/irritation
Skin - rabbit
Result: No skin irritation
(OECD Test Guideline 404)
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Serious eye damage/eye irritation
Eyes - rabbit
Result: Irritating to eyes.
(OECD Test Guideline 405)
Respiratory or skin sensitisation
Maximisation Test - guinea pig
May cause allergic skin reaction.
(OECD Test Guideline 406)
Germ cell mutagenicity
May alter genetic material. In vivo tests showed mutagenic effects
This product is or contains a component that has been reported to be probably carcinogenic based on its
IARC, OSHA, ACGIH, NTP, or EPA classification. Possible human carcinogen
IARC: 2A - Group 2A: Probably carcinogenic to humans (Acrylamide)
Reproductive toxicity
Animal testing did not show any effects on foetal development.
May cause reproductive disorders. Suspected human reproductive toxicant
Specific target organ toxicity - single exposure
no data available Specific target organ toxicity - repeated exposure
Oral - Causes damage to organs through prolonged or repeated exposure. - Peripheral nervous System Aspiration hazard
no data available
Additional Information
RTECS: AS3325000
Liver - Irregularities - Based on Human Evidence
Toxicity to fish LC50 - Pimephales promelas (fathead minnow) - 90 mg/l - 96 h
NOEC - Cyprinus carpio (Carp) - 5 mg/l - 28 d
Toxicity to daphnia and
other aquatic
mortality NOEC - Daphnia magna (Water flea) - 60 mg/l - 48 h
EC50 - Daphnia magna (Water flea) - 160 mg/l - 48 h
12.2 Persistence and degradability
Biodegradability Result: 100 % - Readily biodegradable.
(OECD Test Guideline 301D)
12.3 Bioaccumulative potential
Bioaccumulation Oncorhynchus mykiss (rainbow trout) - 72 h
- 710 &#956;g/l
Bioconcentration factor (BCF): 1,65
12.4 Mobility in soil
no data available
12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
12.6 Other adverse effects
Harmful to aquatic life.
no data available
DISPOSAL CONSIDERATIONS13.1 Waste treatment methods
Offer surplus and non-recyclable solutions to a licensed disposal company. Dissolve or mix the material
with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.
Contaminated packaging
Dispose of as unused product.
ADR/RID: 2074 IMDG: 2074 IATA: 2074
14.2 UN proper shipping name
IATA: Acrylamide, solid
14.3 Transport hazard class(es)
ADR/RID: 6.1 IMDG: 6.1 IATA: 6.1
14.4 Packaging group
ADR/RID: III IMDG: III IATA: III 14.5 Environmental hazards
ADR/RID: no IMDG Marine pollutant: no IATA: no
14.6 Special precautions for user
no data available
REGULATORY INFORMATIONThis safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
Authorisations and/or restrictions on use
Acrylamide CAS-No.: 79-06-1
Candidate List of Substances of Very High Concern for Authorisation
Carcinogenic (article 57a)
Acrylamide CAS-No.: 79-06-1
Candidate List of Substances of Very High Concern for Authorisation
Carcinogenic (article 57a)
15.2 Chemical Safety Assessment
For this product a chemical safety assessment was not carried out
OTHER INFORMATIONThe above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any
guarantee of the properties of the product. For lab use only!