4,4'-MDI

Item number	692503
CAS	101-68-8
Formula	C15H10N2O2
Molecular weight	250,25 g/mol
Quantity	1X250MG
storage conditions	4 °C
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Safety Data Sheet	according to Regulation (EC) No 1907/2006 (REACH) Classifications according to Regulation (EC) No 1272/2008. Printdate 22.06.2025
IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING
Product name:	4,4'-MDI
Catalog No.:	692503
Relevant identified uses of the substance or mixture	Identified: Laboratory chemical uses: R&D
Uses advised against:	HPC Standards GmbH Am Wieseneck 7 04451 Cunnersdorf Deutschland Tel. +49 34291 3372-36 Fax. +49 34291 3372-39 contact@hpc-standards.com
Emergency telephone number	HPC Standards Tel. +49 34291 3372-36 This number is only available during office hours.
HAZARDS IDENTIFICATION	2.1 Classification of the substance or mixture Acute toxicity, (Category 4) H332: Harmful if inhaled. Skin irritation, (Category 2) H315: Causes skin irritation. Eye irritation, (Category 2) H319: Causes serious eye irritation. Respiratory sensitization, (Category 1) H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled. Skin sensitization, (Category 1) H317: May cause an allergic skin reaction. Carcinogenicity, (Category 2) H351: Suspected of causing cancer. Specific target organ toxicity - single exposure, (Category 3), Respiratory system H335: May cause respiratory irritation. Specific target organ toxicity - repeated exposure, (Category 2), Respiratory system H373: May cause damage to organs through prolonged or repeated exposure if inhaled
Label elements
Pictogram	GHS07 exclam exclam GHS08 silhouete silhouete
	Signal Word Danger Hazard Statements H315 Causes skin irritation. H317 May cause an allergic skin reaction. H319 Causes serious eye irritation. H332 Harmful if inhaled. H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled. H335 May cause respiratory irritation. H351 Suspected of causing cancer. H373 May cause damage to organs (Respiratory system) through prolonged or repeated exposure if inhaled. Precautionary Statements P202 Do not handle until all safety precautions have been read and understood. P260 Do not breathe dust. P280 Wear protective gloves/ protective clothing/ eye protection/ face protection. P302 + P352 IF ON SKIN: Wash with plenty of water. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P308 + P313 IF exposed or concerned: Get medical advice/ attention. Supplemental Hazard Statements none 2.3 Other hazards This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher. Ecological information: The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher. Toxicological information: The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher. Lachrymator.
COMPOSITION/INFORMATION ON INGREDIENTS	3.1 Substances Synonyms : 4,4′-MDI Bis(4-isocyanatophenyl)methane Formula : C15H10N2O2 Molecular weight : 250,25 g/mol CAS-No. : 101-68-8 EC-No. : 202-966-0 Index-No. : 615-005-00-9 Classification Acute Tox. 4; Skin Irrit. 2; Eye Irrit. 2; Resp. Sens. 1; Skin Sens. 1; Carc. 2; STOT SE 3; STOT RE 2; H332, H315, H319, H334, H317, H351, H335, H373 Concentration limits: >= 5 %: Eye Irrit. 2, H319; >= 5 %: STOT SE 3, H335; >= 5 %: Skin Irrit. 2, H315; >= 0,1 %: Resp. Sens. 1, H334;
Formula	C15H10N2O2
Molecular Weight (g/mol)	250.25
CAS-No.	101-68-8
FIRST AID MEASURES	4.1 Description of first-aid measures General advice First aiders need to protect themselves. Show this material safety data sheet to the doctor in attendance. If inhaled After inhalation: fresh air. Immediately call in physician. If breathing stops: immediately apply artificial respiration, if necessary also oxygen. In case of skin contact In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Consult a physician. In case of eye contact After eye contact: rinse out with plenty of water. Call in ophthalmologist. Remove contact lenses. If swallowed After swallowing: immediately make victim drink water (two glasses at most). Consult a physician. 4.2 Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11 4.3 Indication of any immediate medical attention and special treatment needed No data available
FIRE-FIGHTING MEASURES	5.1 Extinguishing media Suitable extinguishing media Carbon dioxide (CO2) Dry powder Unsuitable extinguishing media Foam Water 5.2 Special hazards arising from the substance or mixture Carbon oxides Nitrogen oxides (NOx) Combustible. Vapors are heavier than air and may spread along floors. Forms explosive mixtures with air on intense heating. Development of hazardous combustion gases or vapours possible in the event of fire. 5.3 Advice for firefighters Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing. 5.4 Further information Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system
ACCIDENTAL RELEASE MEASURES	6.1 Personal precautions, protective equipment and emergency procedures Advice for non-emergency personnel: Avoid inhalation of dusts. Avoid substance contact. Ensure adequate ventilation. Evacuate the danger area, observe emergency procedures, consult an expert. For personal protection see section 8. 6.2 Environmental precautions Do not let product enter drains. 6.3 Methods and materials for containment and cleaning up Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up carefully. Dispose of properly. Clean up affected area. Avoid generation of dusts. 6.4 Reference to other sections For disposal see section 13.
HANDLING AND STORAGE	7.1 Precautions for safe handling Advice on safe handling Work under hood. Do not inhale substance/mixture. Hygiene measures Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance. For precautions see section 2.2. 7.2 Conditions for safe storage, including any incompatibilities Storage conditions Tightly closed. Dry. Keep locked up or in an area accessible only to qualified or authorized persons. Storage stabilityRecommended storage temperature -20 °C Handle and store under inert gas. Moisture sensitive. Heat sensitive. Storage class Storage class (TRGS 510): 11: Combustible Solids 7.3 Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated
EXPOSURE CONTROLS/PERSONAL PROTECTION	Personal protective equipment Eye/face protection Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Safety glasses Skin protection This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN 16523-1 please contact the supplier of CE-approved gloves Splash contact Material: butyl-rubber Minimum layer thickness: 0,7 mm Break through time: 120 min Body Protection protective clothing Respiratory protection Recommended Filter type: Filter B-(P3) The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer. These measures have to be properly documented. Control of environmental exposure Do not let product enter drains
PHYSICAL AND CHEMICAL PROPERTIES	9.1 Information on basic physical and chemical properties a) Physical state crystalline b) Color white c) Odor No data available d) Melting point/freezing point Melting point/range: 38 - 42 °C - lit. e) Initial boiling point and boiling range 200 °C at 7 hPa - lit. f) Flammability (solid, gas) No data available g) Upper/lower flammability or explosive limits No data available h) Flash point 211 °C - closed cup - Regulation (EC) No. 440/2008, Annex, A.9 i) Autoignition temperature > 601 °C at 1.013 hPa j) Decomposition temperature No data available k) pH No data available l) Viscosity Viscosity, kinematic: No data available Viscosity, dynamic: No data available m) Water solubility No data available n) Partition coefficient: n-octanol/water log Pow: 4,51 at 22 °C - Potential bioaccumulation o) Vapor pressure No data available p) Density 1,18 g/mL at 25 °C - lit. Relative density 1,32 at 20 °C q) Relative vapor density r) Particle characteristics No data available s) Explosive properties No data available t) Oxidizing properties none 9.2 Other safety information No data available
STABILITY AND REACTIVITY	10.1 Reactivity Forms explosive mixtures with air on intense heating. A range from approx. 15 Kelvin below the flash point is to be rated as critical. The following applies in general to flammable organic substances and mixtures: in correspondingly fine distribution, when whirled up a dust explosion potential may generally be assumed. 10.2 Chemical stability The product is chemically stable under standard ambient conditions (room temperature) . 10.3 Possibility of hazardous reactions Violent reactions possible with: Water alkalines Alcohols Amines acids 10.4 Conditions to avoid Strong heating. 10.5 Incompatible materials nonferrous metals, Copper, Copper alloys, Mild steel, Zinc 10.6 Hazardous decomposition products In the event of fire: see section 5
TOXICOLOGICAL INFORMATION	11.1 Information on toxicological effects Acute toxicity LD50 Oral - Rat - 4.130 mg/kg Remarks: (RTECS) Acute toxicity estimate Inhalation - 4 h - 1,5 mg/l - dust/mist (Expert judgment) Inhalation: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2) LD50 Dermal - Rabbit - > 9.000 mg/kg Remarks: (External MSDS) Skin corrosion/irritation Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2) Serious eye damage/eye irritation Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2) Respiratory or skin sensitization Sensitisation test: - Guinea pig Result: positive Remarks: (HSDB) Germ cell mutagenicity Aldrich- 256439 Page 9 of 13 The life science business of Merck operates as MilliporeSigma in the US and Canada Test Type: Ames test Test system: S. typhimurium Metabolic activation: with and without metabolic activation Method: Directive 67/548/EEC, Annex V, B.13. Result: negative Test Type: In vivo micronucleus test Species: Rat Application Route: Inhalation Method: Mutagenicity (micronucleus test) Result: negative Carcinogenicity Suspected of causing cancer. Reproductive toxicity No data available Specific target organ toxicity - single exposure Inhalation - May cause respiratory irritation. - Respiratory system Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2) Specific target organ toxicity - repeated exposure Inhalation - May cause damage to organs through prolonged or repeated exposure. - Respiratory system Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2) Aspiration hazard No data available 11.2 Additional Information Endocrine disrupting properties Product: Assessment : The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher RTECS: NQ9350000 Cough, Shortness of breath, Headache, Nausea, Vomiting, Pulmonary edema. Effects may be delayed. To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
ECOLOGICAL INFORMATION
DISPOSAL CONSIDERATIONS	13.1 Waste treatment methods No data available
TRANSPORT INFORMATION	14.1 UN number ADR/RID: - IMDG: - IATA: - 14.2 UN proper shipping name ADR/RID: Not dangerous goods IMDG: Not dangerous goods IATA: Not dangerous goods 14.3 Transport hazard class(es) ADR/RID: - IMDG: - IATA: - 14.4 Packaging group ADR/RID: - IMDG: - IATA: - 14.5 Environmental hazards ADR/RID: no IMDG Marine pollutant: no IATA: no 14.6 Special precautions for user No data available Further information Not classified as dangerous in the meaning of transport regulations.
REGULATORY INFORMATION
OTHER INFORMATION	The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. For lab use only!

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4,4'-MDI