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Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide

Item number688081
CAS75980-60-8
FormulaC22H21O2P
Molecular weight348,37 g/mol
Quantity 1X100MG
storage conditions20 °C
CoA / MSDSRetrieve CoA
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Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide

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Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide

Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide

688081
75980-60-8

1X100MG

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Safety Data Sheetaccording to Regulation (EC) No 1907/2006 (REACH)
Classifications according to Regulation (EC) No 1272/2008.
Printdate 09.05.2025
IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING
Product name:Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide
Catalog No.:688081
Relevant identified uses of the substance or mixtureIdentified: Laboratory chemical
uses: R&D
Uses advised against:HPC Standards GmbH
Am Wieseneck 7

04451 Cunnersdorf
Deutschland


Tel. +49 34291 3372-36
Fax. +49 34291 3372-39
contact@hpc-standards.com
Emergency telephone numberHPC Standards Tel. +49 34291 3372-36
This number is only available during office hours.
HAZARDS IDENTIFICATION2.1 Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008
Skin sensitization (Category 1), H317
Reproductive toxicity (Category 2), H361f
Long-term (chronic) aquatic hazard (Category 2), H411
Label elements
PictogramGHS07 exclam
exclam
GHS08 silhouete
silhouete
GHS09 Aquatic-pollut-red
Aquatic-pollut-red
2.2 Label elements
Labelling according Regulation (EC) No 1272/2008
Pictogram Signal word Warning
Hazard statement(s)
H317 May cause an allergic skin reaction.
H361f Suspected of damaging fertility.
H411 Toxic to aquatic life with long lasting effects.
Precautionary statement(s)
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and
understood.
P273 Avoid release to the environment.
P280 Wear protective gloves/ protective clothing/ eye protection/ face
protection/ hearing protection.
P302 + P352 IF ON SKIN: Wash with plenty of water.
P308 + P313 IF exposed or concerned: Get medical advice/ attention.
Supplemental Hazard
Statements
none
Reduced Labeling (<= 125 ml)
Pictogram Signal word Warning
Hazard statement(s)
H317 May cause an allergic skin reaction.
H361f Suspected of damaging fertility.
Precautionary statement(s)
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and
understood.
P280 Wear protective gloves/ protective clothing/ eye protection/ face
protection/ hearing protection.
P302 + P352 IF ON SKIN: Wash with plenty of water.
P308 + P313 IF exposed or concerned: Get medical advice/ attention.
Supplemental Hazard
Statements
none
2.3 Other hazards
This substance/mixture contains no components considered to be either persistent,
bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at
levels of 0.1% or higher.
COMPOSITION/INFORMATION ON INGREDIENTS3.1 Substances
Formula : C22H21O2P
Molecular weight : 348,37 g/mol CAS-No. : 75980-60-8
EC-No. : 278-355-8
Index-No. : 015-203-00-X
Component Classification Concentration
Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide
CAS-No.
EC-No.
Index-No.
75980-60-8
278-355-8
015-203-00-X
Skin Sens. 1; Repr. 2;
Aquatic Chronic 2; H317,
H361f, H411
<= 100 %
FormulaC22H21O2P
Molecular Weight (g/mol)348.37
CAS-No.75980-60-8
FIRST AID MEASURES4.1 Description of first-aid measures
No data available
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section
2.2) and/or in section 11
4.3 Indication of any immediate medical attention and special treatment needed
No data available
FIRE-FIGHTING MEASURES5.1 Extinguishing media
No data available
5.2 Special hazards arising from the substance or mixture
Carbon oxides
Oxides of phosphorus
Combustible.
5.3 Advice for firefighters
No data available
5.4 Further information
No data available
ACCIDENTAL RELEASE MEASURES6.1 Personal precautions, protective equipment and emergency procedures
For personal protection see section 8.
6.2 Environmental precautions
No data available
6.3 Methods and materials for containment and cleaning up
No data available
6.4 Reference to other sections
For disposal see section 13
HANDLING AND STORAGE7.1 Precautions for safe handling
For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Light sensitive.
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated
EXPOSURE CONTROLS/PERSONAL PROTECTION8.1 Control parameters
Ingredients with workplace control parameters
8.2 Exposure controls
No data available
PHYSICAL AND CHEMICAL PROPERTIES9.1 Information on basic physical and chemical properties
a) Appearance Form: solid
b) Odor weak characteristic odour
c) Odor Threshold Do not attempt to smell the product as it is hazardous.
d) pH 6,4 - 6,9 at 20 °C
6,4 - 6,9 at 20 °C
e) Melting
point/freezing point
Melting point/range: 88 - 92 °C - lit.
f) Initial boiling point
and boiling range
No data available
g) Flash point Not applicableNot applicable
h) Evaporation rate No data available
i) Flammability (solid,
gas)
No data available
j) Upper/lower
flammability or
explosive limits
No data available
k) Vapor pressure < 0,01 hPa at 25 °C
l) Vapor density No data available
m) Relative density 1,218 at 20 °C - OECD Test Guideline 109
n) Water solubility ca.0,011 g/l at 20 °C - OECD Test Guideline 105
o) Partition coefficient:
n-octanol/water
log Pow: 3,1 at 23 °C - Bioaccumulation is not expected.
p) Autoignition
temperature
does not ignite q) Decomposition
temperature
No data available
r) Viscosity Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
s) Explosive properties No data available
t) Oxidizing properties No data available
9.2 Other safety information
No data available
STABILITY AND REACTIVITY10.1 Reactivity
No data available
10.2 Chemical stability
No data available
10.3 Possibility of hazardous reactions
No data available
10.4 Conditions to avoid
No data available
10.5 Incompatible materials
Strong oxidizing agents
10.6 Hazardous decomposition products
In the event of fire: see section 5
TOXICOLOGICAL INFORMATION11.1 Information on toxicological effects
Acute toxicity
LD50 Oral - Rat - male and female - > 5.000 mg/kg
(OECD Test Guideline 401)
LD50 Dermal Dermal - Rat - male and female - > 2.000 mg/kg
(OECD Test Guideline 402)
Skin corrosion/irritation
Skin - Rabbit
Result: No skin irritation - 24 h
Remarks:
(ECHA)
Serious eye damage/eye irritation
Eyes - Rabbit
Result: No eye irritation
(Draize Test)
Respiratory or skin sensitization
Local lymph node assay (LLNA) - Mouse Result: positive
(OECD Test Guideline 429)
Germ cell mutagenicity
Mutagenicity (mammal cell test): chromosome aberration.
Result: negative
In vitro mammalian cell gene mutation test
Result: negative
Ames test
Escherichia coli/Salmonella typhimurium
Result: negative
Carcinogenicity
IARC: No ingredient of this product present at levels greater than or equal to 0.1% is
identified as probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
Suspected of damaging fertility.
Specific target organ toxicity - single exposure
No data available
Specific target organ toxicity - repeated exposure
No data available
Aspiration hazard
No data available
11.2 Additional Information
Not available
To the best of our knowledge, the chemical, physical, and toxicological properties have not
been thoroughly investigated
ECOLOGICAL INFORMATION12.1 Toxicity
Toxicity to fish semi-static test LC50 - Oryzias latipes (Orange-red killifish) - 6,53
mg/l - 48 h
Remarks: (ECHA)
Toxicity to daphnia
and other aquatic
invertebrates
static test EC50 - Daphnia magna (Water flea) - 3,53 mg/l - 48 h
(OECD Test Guideline 202)
Toxicity to algae static test EC10 - Pseudokirchneriella subcapitata (green algae) -
1,56 mg/l - 72 h
(OECD Test Guideline 201)
static test EC50 - Pseudokirchneriella subcapitata (green algae) - >
2,01 mg/l - 72 h
(OECD Test Guideline 201)
Toxicity to bacteria static test EC50 - activated sludge - > 1.000 mg/l - 3 h (OECD Test Guideline 209)
Remarks: (above the solubility limit in the test medium)
12.2 Persistence and degradability
Biodegradability aerobic - Exposure time 28 d
Result: 0 - 10 % - Not readily biodegradable.
(OECD Test Guideline 301F)
12.3 Bioaccumulative potential
Bioaccumulation Cyprinus carpio (Carp) - 56 d
at 25 °C(Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide)
Bioconcentration factor (BCF): 23 - 55
Remarks: (External MSDS)
12.4 Mobility in soil
No data available
12.5 Results of PBT and vPvB assessment
This substance/mixture contains no components considered to be either persistent,
bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at
levels of 0.1% or higher.
12.6 Other adverse effects
DISPOSAL CONSIDERATIONS13.1 Waste treatment methods
No data available
TRANSPORT INFORMATION14.1 UN number
ADR/RID: 3077 IMDG: 3077 IATA: 3077
14.2 UN proper shipping name
ADR/RID: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (Diphenyl(2,4,6-
trimethylbenzoyl)phosphine oxide)
IMDG: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (Diphenyl(2,4,6-
trimethylbenzoyl)phosphine oxide)
IATA: Environmentally hazardous substance, solid, n.o.s. (Diphenyl(2,4,6-
trimethylbenzoyl)phosphine oxide)
14.3 Transport hazard class(es)
ADR/RID: 9 IMDG: 9 IATA: 9
14.4 Packaging group
ADR/RID: III IMDG: III IATA: III
14.5 Environmental hazards
ADR/RID: yes IMDG Marine pollutant: yes IATA: yes
14.6 Special precautions for user
Further Information EHS-Mark required (ADR 2.2.9.1.10, IMDG code 2.10.3) for single packagings and
combination packagings containing inner packagings with Dangerous Goods > 5L for liquids
or > 5kg for solids.Packages smaller than or equal to 5 kg / L , not dangerous goods of
Class 9
REGULATORY INFORMATION15.1 Safety, health and environmental regulations/legislation specific for the
substance or mixture
This material safety data sheet complies with the requirements of Regulation (EC) No.
1907/2006.
REACH - Restrictions on the manufacture,
placing on the market and use of certain
dangerous substances, preparations and articles
(Annex XVII)
: Not applicable
National legislation
Seveso III: Directive 2012/18/EU of the
European Parliament and of the Council on the
control of major-accident hazards involving
dangerous substances.
: ENVIRONMENTAL HAZARDS
15.2 Chemical Safety Assessment
For this product a chemical safety assessment was not carried out
OTHER INFORMATIONThe above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any
guarantee of the properties of the product. For lab use only!