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2-Aminopyridine

Item number682362
CAS504-29-0
FormulaC5H6N2
Molecular weight94,11 g/mol
Quantity 1X500MG
storage conditions20 °C
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2-Aminopyridine

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Safety Data Sheetaccording to Regulation (EC) No 1907/2006 (REACH)
Classifications according to Regulation (EC) No 1272/2008.
Printdate 29.03.2024
IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING
Product name:2-Aminopyridine
Catalog No.:682362
Relevant identified uses of the substance or mixtureIdentified: Laboratory chemical
uses: R&D
Uses advised against:HPC Standards GmbH
Am Wieseneck 7

04451 Cunnersdorf
Deutschland


Tel. +49 34291 3372-36
Fax. +49 34291 3372-39
contact@hpc-standards.com
Emergency telephone numberHPC Standards Tel. +49 34291 3372-36
This number is only available during office hours.
HAZARDS IDENTIFICATION2.1. Classification of the substance or mixture
Regulation (EC) No 1272/2008
Acute toxicity - Oral Category 3 - (H301)
Acute toxicity - Dermal Category 3 - (H311)
Acute toxicity - Inhalation (Dusts/Mists) Category 3 - (H331)
Skin corrosion/irritation Category 1 Sub-category B - (H314)
Serious eye damage/eye irritation Category 1 - (H318)
Chronic aquatic toxicity Category 3 - (H412)
Label elements
PictogramGHS05 acid
acid
GHS06 skull
skull
2.2. Label elements
207-988-4
Contains 2-Pyridylamine
Signal word
Danger
Hazard statements
H301 - Toxic if swallowed
H311 - Toxic in contact with skin
H314 - Causes severe skin burns and eye damage
H331 - Toxic if inhaled
H412 - Harmful to aquatic life with long lasting effects
Precautionary Statements - EU (§28, 1272/2008)
P260 - Do not breathe dust/fume/gas/mist/vapours/spray
P280 - Wear protective gloves/protective clothing and eye/face protection
P303 + P361 + P353 - IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water [or shower]
P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to
do. Continue rinsing
P310 - Immediately call a POISON CENTER or doctor
P331 - Do NOT induce vomiting
P403 + P233 - Store in a well-ventilated place. Keep container tightly closed
2.3. Other hazards
Harmful to aquatic life.
This substance does not meet the PBT/vPvB criteria of REACH, annex XIII.
Chemical name: 2-Pyridylamine
EU - REACH (1907/2006) - Article 59(1)
- Candidate List of Substances of Very
High Concern (SVHC) for Authorisation: -
EU - REACH (1907/2006) - Endocrine
Disruptor Assessment List of
Substances: -
COMPOSITION/INFORMATION ON INGREDIENTS3.1 Substances
Chemical name: 2-Pyridylamine
504-29-0
Weight-%: 100
REACH registration
number: -
EC No: 207-988-4
Classification
according to
Regulation (EC) No.
1272/2008 [CLP]:
Acute Tox. 3 (H301)
Acute Tox. 3 (H311)
Acute Tox. 3 (H331)
Skin Corr. 1B (H314)
Eye Dam. 1 (H318)
Aquatic Chronic 3
(H412)
Specific
concentration
limit (SCL)
M-Factor
M-Factor
(long-term)
Acute Toxicity Estimate
If LD50/LC50 data is not available or does not correspond to the classification category, then the appropriate conversion
value from CLP Annex I, Table 3.1.2, is used to calculate the acute toxicity estimate (ATEmix) for classifying a mixture
based on its components
Chemical name: 2-Pyridylamine
504-29-0
Oral LD50
mg/kg: 200
Dermal LD50
mg/kg: 1000
Inhalation LC50 - 4
hour - dust/mist - mg/L: No data available
Inhalation LC50 - 4
hour - vapour - mg/L: No data available
nhalation LC50 - 4
hour - gas - ppm: No data available
This product does not contain candidate substances of very high concern at a concentration >=0.1% (Regulation (EC) No.
1907/2006 (REACH), Article 59)
FormulaC5H6N2
Molecular Weight (g/mol)94.11
CAS-No.504-29-0
FIRST AID MEASURES4.1. Description of first aid measures
General advice Show this safety data sheet to the doctor in attendance. Immediate medical attention is
required.
Inhalation Remove to fresh air. If breathing has stopped, give artificial respiration. Get medical
attention immediately. Do not use mouth-to-mouth method if victim ingested or inhaled the
substance; give artificial respiration with the aid of a pocket mask equipped with a one-way
valve or other proper respiratory medical device. If breathing is difficult, (trained personnel
should) give oxygen. Delayed pulmonary edema may occur. Get immediate medical
advice/attention. Do not breathe dust.
Eye contact Get immediate medical advice/attention. Rinse immediately with plenty of water, also under
the eyelids, for at least 15 minutes. Keep eye wide open while rinsing. Do not rub affected
area. Remove contact lenses, if present and easy to do. Continue rinsing.
Skin contact Get immediate medical advice/attention. Wash off immediately with soap and plenty of
water while removing all contaminated clothes and shoes.
Ingestion Do NOT induce vomiting. Rinse mouth. Never give anything by mouth to an unconscious
person. Get immediate medical advice/attention.
Self-protection of the first aider Ensure that medical personnel are aware of the material(s) involved, take precautions to
protect themselves and prevent spread of contamination. Avoid contact with skin, eyes or
clothing. Do not breathe dust. Do not use mouth-to-mouth method if victim ingested or
inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with
a one-way valve or other proper respiratory medical device. Use personal protective
equipment as required. See section 8 for more information.
4.2. Most important symptoms and effects, both acute and delayed
Symptoms Burning sensation. Coughing and/ or wheezing. Difficulty in breathing.
4.3. Indication of any immediate medical attention and special treatment needed
Note to doctors Product is a corrosive material. Use of gastric lavage or emesis is contra-indicated.
Possible perforation of stomach or esophagus should be investigated. Do not give chemical
antidotes. Asphyxia from glottal edema may occur. Marked decrease in blood pressure may
occur with moist rales, frothy sputum, and high pulse pressure.
FIRE-FIGHTING MEASURES5.1. Extinguishing media
Suitable Extinguishing Media Use extinguishing measures that are appropriate to local circumstances and the
surrounding environment.
Large Fire CAUTION: Use of water spray when fighting fire may be inefficient.
Unsuitable extinguishing media Do not scatter spilled material with high pressure water streams.
5.2. Special hazards arising from the substance or mixture
Specific hazards arising from the
chemical
The product causes burns of eyes, skin and mucous membranes. Thermal decomposition
can lead to release of irritating gases and vapours.
5.3. Advice for firefighters
Special protective equipment and
precautions for fire-fighters
Firefighters should wear self-contained breathing apparatus and full firefighting turnout
gear. Use personal protection equipment.
ACCIDENTAL RELEASE MEASURES6.1. Personal precautions, protective equipment and emergency procedures
Personal precautions Avoid contact with skin, eyes or clothing. Ensure adequate ventilation. Use personal
protective equipment as required. Evacuate personnel to safe areas. Attention! Corrosive
material. Keep people away from and upwind of spill/leak. Avoid generation of dust. Do not
breathe dust.
Other information Refer to protective measures listed in Sections 7 and 8.
For emergency responders Use personal protection recommended in Section 8.
6.2. Environmental precautions
Environmental precautions Prevent further leakage or spillage if safe to do so. Should not be released into the
environment. Do not allow to enter into soil/subsoil. Prevent product from entering drains.
6.3. Methods and material for containment and cleaning up
Methods for containment Prevent further leakage or spillage if safe to do so.
Methods for cleaning up Take up mechanically, placing in appropriate containers for disposal.
Prevention of secondary hazards Clean contaminated objects and areas thoroughly observing environmental regulations.
6.4. Reference to other sections
Reference to other sections See section 8 for more information. See section 13 for more information.
HANDLING AND STORAGE7.1. Precautions for safe handling
Advice on safe handling Handle in accordance with good industrial hygiene and safety practice. Avoid contact with
skin, eyes or clothing. Take off contaminated clothing and wash it before reuse. In case of
insufficient ventilation, wear suitable respiratory equipment. Handle product only in closed
system or provide appropriate exhaust ventilation. Do not eat, drink or smoke when using
this product. Do not breathe dust. Avoid generation of dust.
General hygiene considerations Avoid contact with skin, eyes or clothing. Do not eat, drink or smoke when using this
product. Wash hands before breaks and after work. Wear suitable gloves and eye/face
protection. Remove and wash contaminated clothing and gloves, including the inside,
before re-use. Regular cleaning of equipment, work area and clothing is recommended.
Wash hands before breaks and immediately after handling the product. Contaminated work
clothing should not be allowed out of the workplace. Do not breathe dust. Take off
contaminated clothing and wash it before reuse.
7.2. Conditions for safe storage, including any incompatibilities
Storage Conditions Please refer to the manufacturers certificate for specific storage and transport temperature
conditions. Store only in the original receptacle unless other advice is given on the CoA.
Keep containers tightly closed in a dry, cool and well-ventilated place. Keep out of the reach
of children. Store locked up. Protect from moisture. Store away from other materials.
7.3. Specific end use(s)
Risk Management Methods (RMM) The information required is contained in this Safety Data Sheet.
EXPOSURE CONTROLS/PERSONAL PROTECTION8.1. Control parameters
Exposure Limits
Chemical name: 2-Pyridylamine
504-29-0
European Union: -
Austria: TWA: 0.5 ppm
TWA: 2 mg/m3
Belgium: TWA: 0.5 ppm
TWA: 1.9 mg/m3
Bulgaria: -
Croatia: TWA: 0.5 ppm
TWA: 2 mg/m3
STEL: 2 ppm
STEL: 8 mg/m3
STEL: 7.8 mg/m3
Cyprus: -
Czech Republic: TWA: 2 mg/m3
Ceiling: 4 mg/m3
*
Denmark: TWA: 0.5 ppm
TWA: 2 mg/m3
Estonia: -
Finland: TWA: 0.5 ppm
TWA: 2 mg/m3
STEL: 1.5 ppm
STEL: 5.9 mg/m3
France: TWA: 0.5 ppm
TWA: 2 mg/m3
Germany: -
Germany MAK: -
Greece: TWA: 0.5 ppm
TWA: 2 mg/m3
STEL: 2 ppm
STEL: 8 mg/m3
Hungary: -
Ireland: TWA: 0.5 ppm
TWA: 2 mg/m3
STEL: 1.5 ppm
STEL: 6 mg/m3
Italy: -
Italy REL: TWA: 0.5 ppm
TWA: 1.9 mg/m3
Latvia: -
Lithuania: -
Luxembourg: -
Malta: -
Netherlands: -
Norway: TWA: 0.5 ppm
TWA: 2 mg/m3
STEL: 1.5 ppm
STEL: 4 mg/m3
Poland: TWA: 2 mg/m3
*
Portugal: TWA: 0.5 ppm
Romania: -
Slovakia: TWA: 0.5 ppm
TWA: 2 mg/m3
Slovenia: -
Spain: TWA: 0.5 ppm
TWA: 1.9 mg/m3
Sweden: -
Switzerland: TWA: 0.5 ppm
TWA: 2 mg/m3
United Kingdom: TWA: 0.5 ppm
TWA: 2 mg/m3
STEL: 2 ppm
STEL: 7.8 mg/m3
Biological occupational exposure limits
This product, as supplied, does not contain any hazardous materials with biological limits established by the region specific
regulatory bodies
Derived No Effect Level (DNEL) No information available.
Predicted No Effect Concentration
(PNEC)
No information available.
8.2. Exposure controls
Personal protective equipment
Eye/face protection Avoid contact with eyes. Wear safety glasses with side shields (or goggles). Tight sealing
safety goggles. Face protection shield.
Hand protection Wear suitable gloves. Impervious gloves. The protective gloves to be used must comply
with the specifications of EC Directive 89/686/EEC and the related standard EN374. Wear
protective butyl rubber gloves. Polyvinyl chloride (PVC).
Skin and body protection Wear suitable protective clothing. Long sleeved clothing. Chemical resistant apron.
Respiratory protection No protective equipment is needed under normal use conditions. If exposure limits are
exceeded or irritation is experienced, ventilation and evacuation may be required.
General hygiene considerations Avoid contact with skin, eyes or clothing. Do not eat, drink or smoke when using this
product. Wash hands before breaks and after work. Wear suitable gloves and eye/face
protection. Remove and wash contaminated clothing and gloves, including the inside,
before re-use. Regular cleaning of equipment, work area and clothing is recommended.
Wash hands before breaks and immediately after handling the product. Contaminated work clothing should not be allowed out of the workplace. Do not breathe dust. Take off
contaminated clothing and wash it before reuse.
Environmental exposure controls Do not allow into any sewer, on the ground or into any body of water.
PHYSICAL AND CHEMICAL PROPERTIES9.1. Information on basic physical and chemical properties
Physical state Solid
Appearance Solid
Colour light yellow
Odour Characteristic. pyridine-like
Odour threshold No information available
Property Values Remarks • Method
Melting point / freezing point 56 - 59 °C None known
Initial boiling point and boiling
range
204 °C None known
Flammability No data available None known
Flammability Limit in Air None known
Upper flammability or explosive
limits
No data available
Lower flammability or explosive
limits
No data available
Flash point No data available None known
Autoignition temperature > 630 °C None known
Decomposition temperature None known
pH No data available None known
pH (as aqueous solution) No data available No information available
Kinematic viscosity No data available None known
Dynamic viscosity No data available None known
Water solubility Soluble in water 890 g/L @ 21 °C
Solubility(ies) Ether, Alcohols, Benzene, Acetone
Partition coefficient 0.49 None known
Vapour pressure 0.8 mmHg @ 25 °C None known
Relative density 1.065 None known
Bulk density No data available
Liquid Density No data available
Relative vapour density 3.25 None known
Particle characteristics
Particle Size No information available
Particle Size Distribution No information available
9.2. Other information
Molecular weight 94.12
Molecular formula C5 H6 N2
9.2.1. Information with regards to physical hazard classes
Not applicable
9.2.2. Other safety characteristics
No information available
STABILITY AND REACTIVITY10.1. Reactivity
Reactivity No information available.
10.2. Chemical stability
Stability Stable under normal conditions.
Explosion data
Sensitivity to mechanical impact None.
Sensitivity to static discharge None.
10.3. Possibility of hazardous reactions
Possibility of hazardous reactions None under normal processing.
10.4. Conditions to avoid
Conditions to avoid Exposure to air or moisture over prolonged periods. Excessive heat.
10.5. Incompatible materials
Incompatible materials Acids. Bases. Oxidising agent.
Hazardous decomposition products None known based on information supplied.
TOXICOLOGICAL INFORMATION11.1. Information on hazard classes as defined in Regulation (EC) No 1272/2008
Information on likely routes of exposure
Product Information
Inhalation Specific test data for the substance or mixture is not available. Corrosive by inhalation.
(based on components). Inhalation of corrosive fumes/gases may cause coughing, choking,
headache, dizziness, and weakness for several hours. Pulmonary edema may occur with
tightness in the chest, shortness of breath, bluish skin, decreased blood pressure, and
increased heart rate. Inhaled corrosive substances can lead to a toxic edema of the lungs. Pulmonary edema can be fatal. Toxic by inhalation.
Eye contact Specific test data for the substance or mixture is not available. Causes serious eye
damage. (based on components). Corrosive to the eyes and may cause severe damage
including blindness. May cause irreversible damage to eyes.
Skin contact Specific test data for the substance or mixture is not available. Corrosive. (based on
components). Causes burns. Toxic in contact with skin.
Ingestion Specific test data for the substance or mixture is not available. Causes burns. (based on
components). Ingestion causes burns of the upper digestive and respiratory tracts. May
cause severe burning pain in the mouth and stomach with vomiting and diarrhea of dark
blood. Blood pressure may decrease. Brownish or yellowish stains may be seen around the
mouth. Swelling of the throat may cause shortness of breath and choking. May cause lung
damage if swallowed. May be fatal if swallowed and enters airways.
Symptoms related to the physical, chemical and toxicological characteristics
Symptoms Redness. Burning. May cause blindness. Coughing and/ or wheezing. Difficulty in
breathing.
Numerical measures of toxicity
Acute toxicity
Component Information
Chemical name: 2-Pyridylamine
Oral LD50: = 200 mg/kg ( Rat )
Dermal LD50: = 500 mg/kg ( Guinea Pig )
> 1000 mg/kg ( Rabbit )
Inhalation LC50:
Delayed and immediate effects as well as chronic effects from short and long-term exposure
Skin corrosion/irritation Classification based on data available for ingredients. Causes severe skin burns and eye
damage.
Serious eye damage/eye irritation Classification based on data available for ingredients. Causes serious eye damage. Causes
burns.
Respiratory or skin sensitisation No information available
Germ cell mutagenicity No information available.
Carcinogenicity No information available.
Reproductive toxicity No information available.
STOT - single exposure No information available.
STOT - repeated exposure No information available.
Aspiration hazard No information available.
11.2. Information on other hazards
11.2.1. Endocrine disrupting properties
Endocrine disrupting properties No information available.
11.2.2. Other information
Other adverse effects No information available.
ECOLOGICAL INFORMATION12.1. Toxicity
Ecotoxicity Harmful to aquatic life with long lasting effects.
Chemical name: 2-Pyridylamine
Algae/aquatic plants: -
Fish: LC50: = 11 mg/l (96h,
Oryzias latipes)
Toxicity to
microorganisms: -
Crustacea: EC50: =35 mg/L (48h,
Daphnia magna (Water
flea))
12.2. Persistence and degradability
Persistence and degradability No information available.
12.3. Bioaccumulative potential
Bioaccumulation There is no data for this product.
Component Information
Chemical name: 2-Pyridylamine
Partition coefficient: 0.49
12.4. Mobility in soil
Mobility in soil No information available.
12.5. Results of PBT and vPvB assessment
PBT and vPvB assessment This substance is not considered to be persistent, bioaccumulating nor toxic (PBT). This
substance is not considered to be very persistent nor very bioaccumulating (vPvB).
Chemical name: 2-Pyridylamine
PBT and vPvB assessment: PBT assessment does not apply
12.6. Endocrine disrupting properties
Endocrine disrupting properties No information available.
12.7. Other adverse effects
No information available.
DISPOSAL CONSIDERATIONS13.1. Waste treatment methods
Waste from residues/unused
products
Dispose of in accordance with local regulations. Dispose of waste in accordance with
environmental legislation.
Contaminated packaging Do not reuse empty containers.
TRANSPORT INFORMATIONIATA
14.1 UN number or ID number UN2671
14.2 UN proper shipping name Aminopyridines
14.3 Transport hazard class(es) 6.1
14.4 Packing group II
Description UN2671, Aminopyridines, 6.1, II
14.5 Environmental hazards Not applicable
14.6 Special precautions for user
Special Provisions None
ERG Code 6L
IMDG
14.1 UN number or ID number UN2671
14.2 UN proper shipping name Aminopyridines (o-, m-, p-)
14.3 Transport hazard class(es) 6.1
14.4 Packing group II
Description UN2671, Aminopyridines (o-, m-, p-), 6.1, II
14.5 Marine pollutant NP
14.6 Special precautions for user
Special Provisions None
EmS-No F-A, S-A No information available
14.7 Maritime transport in bulk
according to IMO instruments
No information available
RID
14.1 UN number or ID number UN2671
14.2 UN proper shipping name Aminopyridines
14.3 Transport hazard class(es) 6.1
14.4 Packing group II
Description UN2671, Aminopyridines, 6.1, II
14.5 Environmental hazards Not applicable
14.6 Special precautions for user
Special Provisions None
Classification code T2
ADR
14.1 UN number or ID number UN2671
14.2 UN proper shipping name Aminopyridines
14.3 Transport hazard class(es) 6.1
14.4 Packing group II
Description UN2671, Aminopyridines, 6.1, II, (D/E)
14.5 Environmental hazards Not applicable
14.6 Special precautions for user
Special Provisions None
Classification code T2
Tunnel restriction code (D/E)
REGULATORY INFORMATION15.1. Safety, health and environmental regulations/legislation specific for the substance or mixture
National regulations
Germany
Water hazard class (WGK) obviously hazardous to water (WGK 2)
Poland SDS created according to the following Polish regulation: Act of February 25, 2011
on chemical substances and their mixtures (Journal of Laws of 2018, item 143, as
amended). Regulation (EC) No 1907/2006 of the European Parliament and of the
Council on the Registration, Evaluation, Authorization and Restriction of Chemicals
(REACH), establishing the European Chemicals Agency (EC) as amended. Regulation
(EC) No 1272/2008 of the European Parliament and of the Council of 16 December
2008 on classification, labeling and packaging of substances and mixtures, as
amended. Regulation of the Minister of Health of 10 August 2012 on the criteria and
method of classifying chemical substances and their mixtures (Journal of Laws of
2012, item 1018). Regulation of the Minister of Health of 20 April 2012 on labeling
packaging of hazardous substances and mixtures and some mixtures (Journal of
Laws of 2012, item 445). Regulation of the Minister of Family, Labor and Social Policy
of 12 June 2018 on the maximum allowable concentrations and intensities of factors
harmful to health in the work environment (Journal of Laws of 2018, item 1286).
Announcement of the Minister of Economy, Labor and Social Policy of August 28,
2003 on the publication of the unified text of the Ordinance of the Minister of Labor
and Social Policy on general health and safety at work regulations (Journal of Laws
of 2003, No. 169, item 1650) . Regulation of the Minister of Health of 30 December
2004 on occupational safety and health related to the presence of chemical agents in
the workplace (Journal of Laws of 2005, No. 11, item 86). Act of December 14, 2012
on waste (Journal of Laws of 2013, item 21) Regulation of the Minister of Health of
December 30, 2004 on occupational health and safety related to the presence of
chemical agents in the workplace (Journal U. of 2005, No. 11, item 86). Waste Act of
December 14, 2012 (Journal of Laws of 2013, item 21). Act of 13 June 2013 on the
management of packaging and packaging waste, Journal of Laws 2013, item 888).
Government statement of September 24, 2002 - European Agreement on the
International Carriage of Dangerous Goods by Road (ADR) (Journal of Laws No. 194,
item 1629 and Journal of Laws of 2003, No. 207, item 2013 and 2014).
European Union
Take note of Directive 98/24/EC on the protection of the health and safety of workers from the risks related to chemical agents
at work.
Authorisations and/or restrictions on use:
This product does not contain substances subject to authorisation (Regulation (EC) No. 1907/2006 (REACH), Annex XIV) This
product does not contain substances subject to restriction (Regulation (EC) No. 1907/2006 (REACH), Annex XVII)
DIRECTIVE (EU) 2021/1187 on the marketing and use of explosives precursors
Not applicable
Persistent Organic Pollutants
Not applicable
Dangerous substance category per Seveso Directive (2012/18/EU)
H2 - ACUTE TOXIC
Ozone-depleting substances (ODS) regulation (EC) 1005/2009
Not applicable
International Inventories
TSCA Contact supplier for inventory compliance status
DSL/NDSL Contact supplier for inventory compliance status
EINECS/ELINCS Contact supplier for inventory compliance status
ENCS Contact supplier for inventory compliance status
IECSC Contact supplier for inventory compliance status
KECL Contact supplier for inventory compliance status
PICCS Contact supplier for inventory compliance status
AIIC Contact supplier for inventory compliance status
Legend:
TSCA - United States Toxic Substances Control Act Section 8(b) Inventory
DSL/NDSL - Canadian Domestic Substances List/Non-Domestic Substances List
EINECS/ELINCS - European Inventory of Existing Chemical Substances/European List of Notified Chemical Substances
ENCS - Japan Existing and New Chemical Substances
IECSC - China Inventory of Existing Chemical Substances
KECL - Korean Existing and Evaluated Chemical Substances
PICCS - Philippines Inventory of Chemicals and Chemical Substances
AICS - Australian Inventory of Chemical Substances
15.2. Chemical safety assessment
Chemical Safety Report A Chemical Safety Assessment has been carried out for this substance
OTHER INFORMATIONThe above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any
guarantee of the properties of the product. For lab use only!