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Dehydroepiandrosterone

Item number673012
CAS53-43-0
FormulaC19H28O2
Molecular weight288,42 g/mol
Quantity 1X100MG
storage conditions20 °C
CoA / MSDSRetrieve CoA
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Dehydroepiandrosterone

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Safety Data Sheetaccording to Regulation (EC) No 1907/2006 (REACH)
Classifications according to Regulation (EC) No 1272/2008.
Printdate 28.03.2024
IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING
Product name:Dehydroepiandrosterone
Catalog No.:673012
Relevant identified uses of the substance or mixtureIdentified: Laboratory chemical
uses: R&D
Uses advised against:HPC Standards GmbH
Am Wieseneck 7

04451 Cunnersdorf
Deutschland


Tel. +49 34291 3372-36
Fax. +49 34291 3372-39
contact@hpc-standards.com
Emergency telephone numberHPC Standards Tel. +49 34291 3372-36
This number is only available during office hours.
HAZARDS IDENTIFICATION2.1. Classification of the substance or mixture
Regulation (EC) No 1272/2008
Reproductive toxicity Category 1B - (H360)
Effects on or via lactation Yes - (H362)
Acute aquatic toxicity Category 1 - (H400)
Chronic aquatic toxicity Category 1 - (H410)
Label elements
PictogramGHS08 silhouete
silhouete
GHS09 Aquatic-pollut-red
Aquatic-pollut-red
Contains Dehydroepiandrosterone (DHEA)
Signal word
Danger
Hazard statements
H360 - May damage fertility or the unborn child
H362 - May cause harm to breast-fed children
H410 - Very toxic to aquatic life with long lasting effects
Precautionary Statements - EU (§28, 1272/2008)
P201 - Obtain special instructions before use
P260 - Do not breathe dust/fume/gas/mist/vapours/spray
P263 - Avoid contact during pregnancy and while nursing
P273 - Avoid release to the environment
P280 - Wear protective gloves/protective clothing/eye protection/face protection
P308 + P313 - IF exposed or concerned: Get medical advice/attention
P391 - Collect spillage
2.3. Other hazards
No information available.
This substance does not meet the PBT/vPvB criteria of REACH, annex XIII.
Chemical name:Dehydroepiandrosterone (DHEA)
EU - REACH (1907/2006) - Article 59(1)
- Candidate List of Substances of Very
High Concern (SVHC) for Authorisation: -
EU - REACH (1907/2006) - Endocrine
Disruptor Assessment List of
Substances: -
COMPOSITION/INFORMATION ON INGREDIENTS3.1 Substances
Chemical name: Dehydroepiandrosterone (DHEA) 53-43-0
Weight-%: 100
REACH registrationnumber: -
EC No: 200-175-5
Classification according to Regulation (EC) No. 1272/2008 [CLP]: Repr. 1B (H360) Lact. (H362) Aquatic Acute 1 (H400) Aquatic Chronic 1 (H410)
Specificconcentrationlimit (SCL): -
M-Factor: -
M-Factor (long-term):-
Full text of H- and EUH-phrases: see section 16
Acute Toxicity Estimate
If LD50/LC50 data is not available or does not correspond to the classification category, then the appropriate conversion
value from CLP Annex I, Table 3.1.2, is used to calculate the acute toxicity estimate (ATEmix) for classifying a mixture
based on its components
Chemical name: Dehydroepiandrosterone (DHEA) 53-43-0
Oral LD50 mg/kg: 10000
Dermal LD50 mg/kg: No data available
Inhalation LC50 - 4 hour - dust/mist - mg/L: No data available
Inhalation LC50 - 4 hour - vapour - mg/L: No data available
Inhalation LC50 - 4 hour - gas - ppm: No data available
This product does not contain candidate substances of very high concern at a concentration >=0.1% (Regulation (EC) No.
1907/2006 (REACH), Article 59)
FormulaC19H28O2
Molecular Weight (g/mol)288.42
CAS-No.53-43-0
FIRST AID MEASURES4.1. Description of first aid measures
General advice Show this safety data sheet to the doctor in attendance.
Inhalation Remove to fresh air.
Eye contact Rinse thoroughly with plenty of water for at least 15 minutes, lifting lower and upper eyelids.
Consult a doctor.
Skin contact Wash skin with soap and water. In the case of skin irritation or allergic reactions see a
doctor.
Ingestion Rinse mouth.
4.2. Most important symptoms and effects, both acute and delayed
Symptoms No information available.
4.3. Indication of any immediate medical attention and special treatment needed
Note to doctors Treat symptomatically
FIRE-FIGHTING MEASURES5.1. Extinguishing media
Suitable Extinguishing Media Use extinguishing measures that are appropriate to local circumstances and the
surrounding environment.
Large Fire CAUTION: Use of water spray when fighting fire may be inefficient.
Unsuitable extinguishing media Do not scatter spilled material with high pressure water streams.
5.2. Special hazards arising from the substance or mixture
Specific hazards arising from the
chemical
No information available.
5.3. Advice for firefighters
Special protective equipment and
precautions for fire-fighters
Firefighters should wear self-contained breathing apparatus and full firefighting turnout gear.
Use personal protection equipment.
ACCIDENTAL RELEASE MEASURES6.1. Personal precautions, protective equipment and emergency procedures
Personal precautions Ensure adequate ventilation.
For emergency responders Use personal protection recommended in Section 8.
6.2. Environmental precautions
Environmental precautions See Section 12 for additional Ecological Information.
6.3. Methods and material for containment and cleaning up
Methods for containment Prevent further leakage or spillage if safe to do so.
Methods for cleaning up Take up mechanically, placing in appropriate containers for disposal.
Prevention of secondary hazards Clean contaminated objects and areas thoroughly observing environmental regulations.
6.4. Reference to other sections
Reference to other sections See section 8 for more information. See section 13 for more information.
HANDLING AND STORAGE7.1. Precautions for safe handling
Advice on safe handling Handle in accordance with good industrial hygiene and safety practice. Avoid contact with
skin, eyes or clothing. Do not eat, drink or smoke when using this product. Remove
contaminated clothing and shoes.
General hygiene considerations Avoid contact with skin, eyes or clothing. Do not eat, drink or smoke when using this
product. Wash hands before breaks and after work. Wear suitable gloves and eye/face
protection. Wash hands before breaks and immediately after handling the product.
7.2. Conditions for safe storage, including any incompatibilities
Storage Conditions Please refer to the manufacturers certificate for specific storage and transport temperature
conditions. Store only in the original receptacle unless other advice is given on the CoA.
7.3. Specific end use(s)
Risk Management Methods (RMM) The information required is contained in this Safety Data Sheet.
EXPOSURE CONTROLS/PERSONAL PROTECTION8.1. Control parameters
Exposure Limits This product, as supplied, does not contain any hazardous materials with occupational
exposure limits established by the region specific regulatory bodies.
Biological occupational exposure limits
This product, as supplied, does not contain any hazardous materials with biological limits established by the region specific
regulatory bodies
Derived No Effect Level (DNEL) No information available.
Predicted No Effect Concentration
(PNEC)
No information available.
8.2. Exposure controls
Personal protective equipment
Eye/face protection Avoid contact with eyes. Wear safety glasses with side shields (or goggles).
Hand protection Wear suitable gloves. The protective gloves to be used must comply with the specifications
of EC Directive 89/686/EEC and the related standard EN374. Wear protective nitrile rubber
gloves
Gloves:
PPE - Glove material: Wear protective nitrile rubber gloves
Glove thickness: 0,11mm
Break through time: 480 minutes
Skin and body protection Wear suitable protective clothing.
Respiratory protection No protective equipment is needed under normal use conditions. If exposure limits are
exceeded or irritation is experienced, ventilation and evacuation may be required.
General hygiene considerations Avoid contact with skin, eyes or clothing. Do not eat, drink or smoke when using this
product. Wash hands before breaks and after work. Wear suitable gloves and eye/face
protection. Wash hands before breaks and immediately after handling the product.
Environmental exposure controls Do not allow into any sewer, on the ground or into any body of water.
PHYSICAL AND CHEMICAL PROPERTIES9.1. Information on basic physical and chemical properties
Physical state Solid
Appearance Solid
Colour white
Odour Odourless.
Odour threshold No information available
Property Values Remarks • Method
Melting point / freezing point 147 - 152 °C None known
Initial boiling point and boiling rangeNo data available None known
Flammability No data available None known
Flammability Limit in Air None known
Upper flammability or explosive
limits
No data available
Lower flammability or explosive
limits
No data available
Flash point No data available None known
Autoignition temperature No data available None known
Decomposition temperature None known
pH No data available None known
pH (as aqueous solution) No data available No information available
Kinematic viscosity No data available None known
Dynamic viscosity No data available None known
Water solubility No data available 0.017 g/l at 20 °C None known
Solubility(ies) Methanol, Acetonitrile, Ethanol, slightly
soluble
Partition coefficient 3.03 None known
Vapour pressure < 1 hPa at 25 °C None known
Relative density 1.159 None known
Bulk density No data available
Liquid Density No data available
Relative vapour density No data available None known
Particle characteristics
Particle Size No information available
Particle Size Distribution No information available
9.2. Other information
Molecular weight 288.43
Molecular formula C19 H28 O2
9.2.1. Information with regards to physical hazard classes
Not applicable
9.2.2. Other safety characteristics
No information available
STABILITY AND REACTIVITY10.1. Reactivity
Reactivity No information available.
10.2. Chemical stability
Stability Stable under normal conditions.
Explosion data
Sensitivity to mechanical impact None.
Sensitivity to static discharge None.
10.3. Possibility of hazardous reactions
Possibility of hazardous reactions None under normal processing.
10.4. Conditions to avoid
Conditions to avoid None known based on information supplied.
10.5. Incompatible materials
Incompatible materials None known based on information supplied.
Hazardous decomposition products None known based on information supplied.
TOXICOLOGICAL INFORMATION11.1. Information on hazard classes as defined in Regulation (EC) No 1272/2008
Information on likely routes of exposure
Product Information
Inhalation Specific test data for the substance or mixture is not available.
Eye contact Specific test data for the substance or mixture is not available.
Skin contact Specific test data for the substance or mixture is not available.
Ingestion Specific test data for the substance or mixture is not available.
Symptoms related to the physical, chemical and toxicological characteristics
Symptoms No information available.
Numerical measures of toxicity
Acute toxicity
Component Information
Chemical name:Dehydroepiandrosterone (DHEA)
Oral LD50: > 10 g/kg ( Rat )
Dermal LD50: -
Inhalation LC50: -
Delayed and immediate effects as well as chronic effects from short and long-term exposure
Skin corrosion/irritation Based on available data, the classification criteria are not met.
Serious eye damage/eye irritation No information available.
Respiratory or skin sensitisation No information available.
Germ cell mutagenicity No information available.
Carcinogenicity No information available.
Reproductive toxicity Contains a known or suspected reproductive toxin. Classification based on data available
for ingredients. May damage fertility or the unborn child. May cause harm to breast-fed
children.
STOT - single exposure No information available.
STOT - repeated exposure No information available.
Aspiration hazard No information available.
11.2. Information on other hazards
11.2.1. Endocrine disrupting properties
Endocrine disrupting properties No information available.
11.2.2. Other information
Other adverse effects No information available.
ECOLOGICAL INFORMATION12.1. Toxicity
Ecotoxicity Very toxic to aquatic life with long lasting effects.
Chemical name:Dehydroepiandrosterone (DHEA)
Algae/aquatic plants: EC50: = 0.01 mg/L (72h, Desmodesmus subspicatus )
Fish: -
Toxicity to microorganisms: -
Crustacea: EC50: = 5.4 mg/L (48h, Daphnia magna )
12.2. Persistence and degradability
Persistence and degradability No information available.
12.3. Bioaccumulative potential
Bioaccumulation There is no data for this product.
Component Information
Chemical name: Dehydroepiandrosterone (DHEA)
Partition coefficient: 3.03
12.4. Mobility in soil
Mobility in soil No information available.
12.5. Results of PBT and vPvB assessment
PBT and vPvB assessment This substance is not considered to be persistent, bioaccumulating nor toxic (PBT). This
substance is not considered to be very persistent nor very bioaccumulating (vPvB).
12.6. Endocrine disrupting properties
Endocrine disrupting properties No information available.
12.7. Other adverse effects
No information available
DISPOSAL CONSIDERATIONS13.1. Waste treatment methods
Waste from residues/unused
products
Dispose of in accordance with local regulations. Dispose of waste in accordance with
environmental legislation.
Contaminated packaging Do not reuse empty containers.
TRANSPORT INFORMATIONIATA
14.1 UN number or ID number UN3077
14.2 UN proper shipping name Environmentally hazardous substances, solid, n.o.s. (Dehydroepiandrosterone (DHEA))
14.3 Transport hazard class(es) 9
14.4 Packing group III
Description UN3077, Environmentally hazardous substances, solid, n.o.s. (Dehydroepiandrosterone
(DHEA)), 9, III
14.5 Environmental hazards Yes
14.6 Special precautions for user
Special Provisions A97, A158, A179, A197, A215
ERG Code 9L
IMDG
14.1 UN number or ID number UN3077
14.2 UN proper shipping name Environmentally hazardous substances, solid, n.o.s. (Dehydroepiandrosterone (DHEA))
14.3 Transport hazard class(es) 9
14.4 Packing group III
Description UN3077, Environmentally hazardous substances, solid, n.o.s. (Dehydroepiandrosterone
(DHEA)), 9, III, Marine pollutant
14.5 Marine pollutant P
Environmental hazards Yes
14.6 Special precautions for user
Special Provisions 274, 335, 966, 967, 969
EmS-No F-A, S-F No information available
14.7 Maritime transport in bulk
according to IMO instruments
No information available
RID
14.1 UN number or ID number UN3077
14.2 UN proper shipping name Environmentally hazardous substances, solid, n.o.s. (Dehydroepiandrosterone (DHEA))
14.3 Transport hazard class(es) 9
14.4 Packing group III
Description UN3077, Environmentally hazardous substances, solid, n.o.s. (Dehydroepiandrosterone
(DHEA)), 9, III
14.5 Environmental hazards Yes
14.6 Special precautions for user
Special Provisions 274, 335, 375, 601
Classification code M7
ADR
14.1 UN number or ID number UN3077
14.2 UN proper shipping name Environmentally hazardous substances, solid, n.o.s. (Dehydroepiandrosterone (DHEA))
14.3 Transport hazard class(es) 9
14.4 Packing group III
Description UN3077, Environmentally hazardous substances, solid, n.o.s. (Dehydroepiandrosterone
(DHEA)), 9, III, (-)
14.5 Environmental hazards Yes
14.6 Special precautions for user
Special Provisions 274, 335, 601, 375
Classification code M7
Tunnel restriction code (-)
REGULATORY INFORMATION15.1. Safety, health and environmental regulations/legislation specific for the substance or mixture
Water hazard class (WGK) strongly hazardous to water (WGK 3)
Poland SDS created according to the following Polish regulation: Act of February 25, 2011 on
chemical substances and their mixtures (Journal of Laws of 2018, item 143, as
amended). Regulation (EC) No 1907/2006 of the European Parliament and of the
Council on the Registration, Evaluation, Authorization and Restriction of Chemicals
(REACH), establishing the European Chemicals Agency (EC) as amended. Regulation
(EC) No 1272/2008 of the European Parliament and of the Council of 16 December
2008 on classification, labeling and packaging of substances and mixtures, as
amended. Regulation of the Minister of Health of 10 August 2012 on the criteria and
method of classifying chemical substances and their mixtures (Journal of Laws of
2012, item 1018). Regulation of the Minister of Health of 20 April 2012 on labeling
packaging of hazardous substances and mixtures and some mixtures (Journal of
Laws of 2012, item 445). Regulation of the Minister of Family, Labor and Social Policy
of 12 June 2018 on the maximum allowable concentrations and intensities of factors
harmful to health in the work environment (Journal of Laws of 2018, item 1286).
Announcement of the Minister of Economy, Labor and Social Policy of August 28,
2003 on the publication of the unified text of the Ordinance of the Minister of Labor
and Social Policy on general health and safety at work regulations (Journal of Laws
of 2003, No. 169, item 1650) . Regulation of the Minister of Health of 30 December
2004 on occupational safety and health related to the presence of chemical agents in
the workplace (Journal of Laws of 2005, No. 11, item 86). Act of December 14, 2012 on
waste (Journal of Laws of 2013, item 21) Regulation of the Minister of Health of
December 30, 2004 on occupational health and safety related to the presence of
chemical agents in the workplace (Journal U. of 2005, No. 11, item 86). Waste Act of
December 14, 2012 (Journal of Laws of 2013, item 21). Act of 13 June 2013 on the
management of packaging and packaging waste, Journal of Laws 2013, item 888).
Government statement of September 24, 2002 - European Agreement on the
International Carriage of Dangerous Goods by Road (ADR) (Journal of Laws No. 194,
item 1629 and Journal of Laws of 2003, No. 207, item 2013 and 2014).
European Union
Take note of Directive 98/24/EC on the protection of the health and safety of workers from the risks related to chemical agents
at work.
Authorisations and/or restrictions on use:
This product does not contain substances subject to authorisation (Regulation (EC) No. 1907/2006 (REACH), Annex XIV) This
product does not contain substances subject to restriction (Regulation (EC) No. 1907/2006 (REACH), Annex XVII)
DIRECTIVE (EU) 2021/1187 on the marketing and use of explosives precursors
Not applicable
Persistent Organic Pollutants
Not applicable
Dangerous substance category per Seveso Directive (2012/18/EU)
E1 - Hazardous to the Aquatic Environment in Category Acute 1 or Chronic 1
Ozone-depleting substances (ODS) regulation (EC) 1005/2009
Not applicable
International Inventories
TSCA Complies under research and development exemption or is regulated by a different
government agency.
DSL/NDSL Contact supplier for inventory compliance status
EINECS/ELINCS Contact supplier for inventory compliance status
ENCS Contact supplier for inventory compliance status
IECSC Contact supplier for inventory compliance status
KECL Contact supplier for inventory compliance status
PICCS Contact supplier for inventory compliance status
AIIC Contact supplier for inventory compliance status
Legend:
TSCA - United States Toxic Substances Control Act Section 8(b) Inventory
DSL/NDSL - Canadian Domestic Substances List/Non-Domestic Substances List
EINECS/ELINCS - European Inventory of Existing Chemical Substances/European List of Notified Chemical Substances
ENCS - Japan Existing and New Chemical Substances
IECSC - China Inventory of Existing Chemical Substances
KECL - Korean Existing and Evaluated Chemical Substances
PICCS - Philippines Inventory of Chemicals and Chemical Substances
AICS - Australian Inventory of Chemical Substances
15.2. Chemical safety assessment
Chemical Safety Report A Chemical Safety Assessment is not required for this substance
OTHER INFORMATIONThe above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any
guarantee of the properties of the product. For lab use only!