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1,2-Dimethoxyethane

Item number	679777
CAS	110-71-4
Formula	C4H10O2
Molecular weight	90,12 g/mol
Quantity	1X1ML
storage conditions	20 °C
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Safety Data Sheet	according to Regulation (EC) No 1907/2006 (REACH) Classifications according to Regulation (EC) No 1272/2008. Printdate 26.04.2024
IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING
Product name:	1,2-Dimethoxyethane
Catalog No.:	679777
Relevant identified uses of the substance or mixture	Identified: Laboratory chemical uses: R&D
Uses advised against:	HPC Standards GmbH Am Wieseneck 7 04451 Cunnersdorf Deutschland Tel. +49 34291 3372-36 Fax. +49 34291 3372-39 contact@hpc-standards.com
Emergency telephone number	HPC Standards Tel. +49 34291 3372-36 This number is only available during office hours.
HAZARDS IDENTIFICATION	2.1 Classification of the substance or mixture Classification according to Regulation (EC) No 1272/2008 Flammable liquids (Category 2), H225 Acute toxicity, Inhalation (Category 4), H332 Skin irritation (Category 2), H315 Reproductive toxicity (Category 1B), H360FD For the full text of the H-Statements mentioned in this Section, see Section 16.
Label elements
Pictogram	flamme flamme GHS07 exclam exclam GHS08 silhouete silhouete
	2.2 Label elements Labelling according Regulation (EC) No 1272/2008 Signal word Danger Hazard statement(s) H225 Highly flammable liquid and vapor. H315 Causes skin irritation. H332 Harmful if inhaled. H360FD May damage fertility. May damage the unborn child. Precautionary statement(s) P202 Do not handle until all safety precautions have been read and understood. P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P233 Keep container tightly closed. P303 + P361 + P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water. P304 + P340 + P312 IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/ doctor if you feel unwell. P308 + P313 IF exposed or concerned: Get medical advice/ attention. Supplemental Hazard information (EU) EUH019 May form explosive peroxides. Restricted to professional users. Reduced Labeling (<= 125 ml) Signal word Danger Hazard statement(s) H360FD May damage fertility. May damage the unborn child. Precautionary statement(s) P202 Do not handle until all safety precautions have been read and understood. P308 + P313 IF exposed or concerned: Get medical advice/ attention. Supplemental Hazard information (EU) EUH019 May form explosive peroxides. 2.3 Other hazards This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
COMPOSITION/INFORMATION ON INGREDIENTS	3.1 Substances Synonyms : Monoglyme Dimethylglycol mono-Glyme Ethylene glycol dimethyl ether Formula : C4H10O2 Molecular weight : 90,12 g/mol CAS-No. : 110-71-4 EC-No. : 203-794-9 Index-No. : 603-031-00-3 Component 1,2-dimethoxy-ethane Included in the Candidate List of Substances of Very High Concern (SVHC) according to Regulation (EC) No. 1907/2006 (REACH) CAS-No. : 110-71-4 EC-No. : 203-794-9 Index-No. : 603-031-00-3 Classification Flam. Liq. 2; Acute Tox. 4; Skin Irrit. 2; Repr. 1B; H225, H332, H315, H360FD Concentration <= 100 %
Formula	C4H10O2
Molecular Weight (g/mol)	90.12
CAS-No.	110-71-4
FIRST AID MEASURES	4.1 Description of first-aid measures General advice Show this material safety data sheet to the doctor in attendance. If inhaled If breathing stops: immediately apply artificial respiration, if necessary also oxygen. In case of skin contact In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Consult a physician. In case of eye contact After eye contact: rinse out with plenty of water. Call in ophthalmologist. Remove contact lenses. If swallowed After swallowing: immediately make victim drink water (two glasses at most). Consult a physician. 4.2 Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11 4.3 Indication of any immediate medical attention and special treatment needed No data available
FIRE-FIGHTING MEASURES	5.1 Extinguishing media Suitable extinguishing media Water Foam Carbon dioxide (CO2) Dry powder Unsuitable extinguishing media For this substance/mixture no limitations of extinguishing agents are given. 5.2 Special hazards arising from the substance or mixture Carbon oxides Combustible. Pay attention to flashback. Vapors are heavier than air and may spread along floors. Risk of dust explosion. Development of hazardous combustion gases or vapours possible in the event of fire. Forms explosive mixtures with air at ambient temperatures. 5.3 Advice for firefighters Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing. 5.4 Further information Remove container from danger zone and cool with water. Prevent fire extinguishing water from contaminating surface water or the ground water system.
ACCIDENTAL RELEASE MEASURES	6.1 Personal precautions, protective equipment and emergency procedures Advice for non-emergency personnel: Do not breathe vapors, aerosols. Avoid substance contact. Ensure adequate ventilation. Keep away from heat and sources of ignition. Evacuate the danger area, observe emergency procedures, consult an expert. For personal protection see section 8. 6.2 Environmental precautions Do not let product enter drains. Risk of explosion. 6.3 Methods and materials for containment and cleaning up Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up carefully with liquid-absorbent material (e.g. Chemizorb®). Dispose of properly. Clean up affected area. 6.4 Reference to other sections For disposal see section 13.
HANDLING AND STORAGE	7.1 Precautions for safe handling Advice on safe handling Work under hood. Do not inhale substance/mixture. Avoid generation of vapours/aerosols. Advice on protection against fire and explosion Keep away from open flames, hot surfaces and sources of ignition.Take precautionary measures against static discharge. Hygiene measures Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance. For precautions see section 2.2. 7.2 Conditions for safe storage, including any incompatibilities Storage conditions Keep container tightly closed in a dry and well-ventilated place. Keep away from heat and sources of ignition. Keep locked up or in an area accessible only to qualified or authorized persons. Test for peroxide formation periodically and before distillation. 7.3 Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated
EXPOSURE CONTROLS/PERSONAL PROTECTION	8.1 Control parameters Ingredients with workplace control parameters 8.2 Exposure controls Personal protective equipment Eye/face protection Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Safety glasses Skin protection This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de). Full contact Material: Viton® Minimum layer thickness: 0,7 mm Break through time: 480 min Material tested:Vitoject® (KCL 890 / Aldrich Z677698, Size M) This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de). Splash contact Material: Nitrile rubber Minimum layer thickness: 0,4 mm Break through time: 10 min Material tested:Camatril® (KCL 730 / Aldrich Z677442, Size M) Body Protection Flame retardant antistatic protective clothing. Respiratory protection required when vapours/aerosols are generated. Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system. Recommended Filter type: Filter type ABEK The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer. These measures have to be properly documented. Control of environmental exposure Do not let product enter drains. Risk of explosion.
PHYSICAL AND CHEMICAL PROPERTIES	9.1 Information on basic physical and chemical properties a) Appearance Form: liquid, clear Color: colorless b) Odor ether-like c) Odor Threshold not determined d) pH ca.7neutral e) Melting point/freezing point Melting point/range: -58 °C - lit. f) Initial boiling point and boiling range 85 °C - lit. g) Flash point 5 °C - closed cup h) Evaporation rate No data available i) Flammability (solid, gas) No data available j) Upper/lower flammability or explosive limits Upper explosion limit: 10,4 %(V) Lower explosion limit: 1,6 %(V) k) Vapor pressure 87 hPa at 25 °C - OECD Test Guideline 104 l) Vapor density 3,11 - (Air = 1.0) m) Density 0,867 g/cm3 at 25 °C - lit. Relative density 0,87 at 20 °C - OECD Test Guideline 109 n) Water solubility 1.000 g/l at 25 °C - soluble o) Partition coefficient: n-octanol/water log Pow: -0,21 at 25 °C - (experimental) - Bioaccumulation is not expected. p) Autoignition temperature No data available q) Decomposition temperature No data available r) Viscosity Viscosity, kinematic: 0,48 mm2/s at 20 °C - OECD Test Guideline 114 Viscosity, dynamic: 0,42 mPa.s at 20 °C - OECD Test Guideline 114 s) Explosive properties No data available t) Oxidizing properties No data available 9.2 Other safety information Surface tension 70,7 mN/m at 1g/l at 23 °C - OECD Test Guideline 115 Relative vapor density 3,11 - (Air = 1.0)
STABILITY AND REACTIVITY	10.1 Reactivity Formation of peroxides possible. Vapors may form explosive mixture with air. 10.2 Chemical stability The product is chemically stable under standard ambient conditions (room temperature) . Stable under recommended storage conditions. 10.3 Possibility of hazardous reactions No data available 10.4 Conditions to avoid Warming. Moisture. 10.5 Incompatible materials Oxidizing agents, Strong acids, Strong oxidizing agents 10.6 Hazardous decomposition products Peroxides In the event of fire: see section 5
TOXICOLOGICAL INFORMATION	11.1 Information on toxicological effects Acute toxicity LD50 Oral - Rat - female - 5.370 mg/kg (OECD Test Guideline 401) Acute toxicity estimate Inhalation - 11,1 mg/l (Expert judgment) Remarks: (Regulation (EC) No 1272/2008, Annex VI) Acute toxicity estimate Inhalation - 11,1 mg/l (Expert judgment) Remarks: (Regulation (EC) No 1272/2008, Annex VI) LD50 Dermal - Rat - female - > 5.000 mg/kg (OECD Test Guideline 402) Skin corrosion/irritation Skin - Rabbit Result: Irritating to skin. - 24 h (OECD Test Guideline 404) Serious eye damage/eye irritation Eyes - Rabbit Result: No eye irritation - 24 h (OECD Test Guideline 405) Respiratory or skin sensitization Local lymph node assay (LLNA) - Mouse Result: negative (OECD Test Guideline 429) Remarks: The value is given in analogy to the following substances: 1-ethoxy-2-(2- methoxyethoxy)ethane Germ cell mutagenicity Not mutagenic in Ames Test. Did not show mutagenic effects in animal experiments. Test Type: unscheduled DNA synthesis assay Test system: Human lymphocytes Metabolic activation: with and without metabolic activation Method: OECD Test Guideline 482 Result: negative Test Type: Ames test Test system: Escherichia coli/Salmonella typhimurium Metabolic activation: with and without metabolic activation Method: OECD Test Guideline 471 Result: negative Test Type: sister chromatid exchange assay Test system: Chinese hamster ovary cells Metabolic activation: with and without metabolic activation Method: OECD Test Guideline 479 Result: positive Test Type: In vivo micronucleus test Species: Mouse Cell type: Bone marrow Application Route: Oral Method: OECD Test Guideline 474 Result: negative Test Type: Chromosome aberration test Species: Chinese hamster Cell type: Bone marrow Application Route: Oral Method: OECD Test Guideline 475 Result: negative Carcinogenicity No data available Reproductive toxicity May damage the unborn child. May damage fertility. Specific target organ toxicity - single exposure No data available Specific target organ toxicity - repeated exposure No data available Aspiration hazard No aspiration toxicity classification 11.2 Additional Information RTECS: KI1451000 narcosis, Exposure to and/or consumption of alcohol may increase toxic effects. To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
ECOLOGICAL INFORMATION	12.1 Toxicity Toxicity to fish static test LC50 - Danio rerio (zebra fish) - > 5.000 mg/l - 96 h (OECD Test Guideline 203) Remarks: The value is given in analogy to the following substances: Tegdme Toxicity to daphnia and other aquatic invertebrates semi-static test EC50 - Daphnia magna (Water flea) - 4.000 mg/l - 48 h (OECD Test Guideline 202) Toxicity to algae static test ErC50 - Pseudokirchneriella subcapitata (green algae) - 9.120 mg/l - 72 h (OECD Test Guideline 201) Toxicity to bacteria static test EC50 - activated sludge - > 6.400 mg/l - 3 h (OECD Test Guideline 209) 12.2 Persistence and degradability Biodegradability aerobic - Exposure time 48 d Result: 16 % - According to the results of tests of biodegradability this product is not readily biodegradable. (OECD Test Guideline 302B) Chemical Oxygen Demand (COD) 1.700 mg/g Remarks: (External MSDS) 12.3 Bioaccumulative potential Due to the distribution coefficient n-octanol/water, accumulation in organisms is not expected. 12.4 Mobility in soil No data available 12.5 Results of PBT and vPvB assessment This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher. 12.6 Other adverse effects
DISPOSAL CONSIDERATIONS	13.1 Waste treatment methods Product See www.retrologistik.com for processes regarding the return of chemicals and containers, or contact us there if you have further questions.
TRANSPORT INFORMATION	14.1 UN number ADR/RID: 2252 IMDG: 2252 IATA: 2252 14.2 UN proper shipping name ADR/RID: 1,2-DIMETHOXYETHANE IMDG: 1,2-DIMETHOXYETHANE IATA: 1,2-Dimethoxyethane 14.3 Transport hazard class(es) ADR/RID: 3 IMDG: 3 IATA: 3 14.4 Packaging group ADR/RID: II IMDG: II IATA: II 14.5 Environmental hazards ADR/RID: no IMDG Marine pollutant: no IATA: no 14.6 Special precautions for user No data available
REGULATORY INFORMATION	15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture This material safety data sheet complies with the requirements of Regulation (EC) No. 1907/2006. Authorisations and/or restrictions on use REACH - Candidate List of Substances of Very High Concern for Authorisation (Article 59). : 1,2-dimethoxy-ethane REACH - Restrictions on the manufacture, placing on the market and use of certain dangerous substances, preparations and articles (Annex XVII) : 1,2-dimethoxy-ethane National legislation Seveso III: Directive 2012/18/EU of the European Parliament and of the Council on the control of major-accident hazards involving dangerous substances. : FLAMMABLE LIQUIDS Other regulations Observe work restrictions regarding maternity protection in accordance to Dir 92/85/EEC or stricter national regulations where applicable. Take note of Dir 94/33/EC on the protection of young people at work. 15.2 Chemical Safety Assessment A Chemical Safety Assessment has been carried out for this substance.
OTHER INFORMATION	The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. For lab use only!