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Entecavir monohydrate

Item number693458
CAS209216-23-9
FormulaC12H17N5O4
Molecular weight295,29 g/mol
Quantity 1X100MG
storage conditions4 °C
CoA / MSDSRetrieve CoA
Retrieve MSDS
Entecavir monohydrate

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Entecavir monohydrate

Entecavir monohydrate

693458
209216-23-9

1X100MG

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Safety Data Sheetaccording to Regulation (EC) No 1907/2006 (REACH)
Classifications according to Regulation (EC) No 1272/2008.
Printdate 07.10.2025
IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING
Product name:Entecavir monohydrate
Catalog No.:693458
Relevant identified uses of the substance or mixtureIdentified: Laboratory chemical
uses: R&D
Uses advised against:HPC Standards GmbH
Am Wieseneck 7

04451 Cunnersdorf
Deutschland


Tel. +49 34291 3372-36
Fax. +49 34291 3372-39
contact@hpc-standards.com
Emergency telephone numberHPC Standards Tel. +49 34291 3372-36
This number is only available during office hours.
HAZARDS IDENTIFICATION
Label elements
PictogramGHS07 exclam
exclam
GHS08 silhouete
silhouete
Label elements
· GHS label elements
The substance is classified and labeled according to the Globally Harmonized System (GHS).
Signal word Warning
· Hazard statements
H315 Causes skin irritation.
H319 Causes serious eye irritation.
H351 Suspected of causing cancer.
H361-H362 Suspected of damaging fertility or the unborn child. May cause harm to breast-fed children.
· Precautionary statements
P260 Do not breathe dusts or mists.
P263 Avoid contact during pregnancy/while nursing.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if
present and easy to do. Continue rinsing.
P405 Store locked up.
P501 Dispose of contents/container in accordance with local/regional/national/international
regulations.
· Classification system:
· NFPA ratings (scale 0 - 4)
2 0 0
Health = 2
Fire = 0
Reactivity = 0
· HMIS-ratings (scale 0 - 4)
HEALTH
FIRE
REACTIVITY
2
0
0
Health = 2
Fire = 0
Reactivity = 0
· Other hazards
· Results of PBT and vPvB assessment
· PBT: Not applicable.
· vPvB: Not applicable
COMPOSITION/INFORMATION ON INGREDIENTS Chemical characterization: Substances
· CAS No. Description
209216-23-9 Entecavir Monohydrate
· Identification number(s) -
· EC number: 606-668-5
RTECS: -
FormulaC12H17N5O4
Molecular Weight (g/mol)295.29
CAS-No.209216-23-9
FIRST AID MEASURES Description of first aid measures
· After inhalation: Supply fresh air; consult doctor in case of complaints.
· After skin contact:
Immediately wash with water and soap and rinse thoroughly.
If skin irritation continues, consult a doctor.
· After eye contact:
Rinse opened eye for several minutes under running water. If symptoms persist, consult a doctor.
· After swallowing: Rinse mouth. Do not induce vomiting.
· Information for doctor:
· Most important symptoms and effects, both acute and delayed No further relevant information available.
· Indication of any immediate medical attention and special treatment needed
No further relevant information available
FIRE-FIGHTING MEASURESExtinguishing media
· Suitable extinguishing agents: Use fire fighting measures that suit the environment.
· Special hazards arising from the substance or mixture
Formation of toxic gases is possible during heating or in case of fire.
· Advice for firefighters
· Protective equipment: Wear self-contained respiratory protective device
ACCIDENTAL RELEASE MEASURESPersonal precautions, protective equipment and emergency procedures Avoid formation of dust.
· Environmental precautions: Do not allow to enter sewers/ surface or ground water.
· Methods and material for containment and cleaning up:
Dispose contaminated material as waste according to item 13.
· Reference to other sections
See Section 7 for information on safe handling.
See Section 8 for information on personal protection equipment.
See Section 13 for disposal information.
· Protective Action Criteria for Chemicals
· PAC-1: Substance is not listed.
· PAC-2: Substance is not listed.
· PAC-3: Substance is not listed
HANDLING AND STORAGEHandling:
· Precautions for safe handling Store in cool, dry place in tightly closed receptacles.
· Information about protection against explosions and fires: No special measures required.
· Conditions for safe storage, including any incompatibilities
· Storage:
· Requirements to be met by storerooms and receptacles:
Please refer to the manufacturers certificate for specific storage and transport temperature conditions.
Store only in the original receptacle unless other advice is given on the CoA.
Keep container in a well-ventilated place. Keep away from sources of ignition and heat.
· Information about storage in one common storage facility: Store away from foodstuffs.
· Further information about storage conditions: Keep receptacle tightly sealed.
· Specific end use(s) No further relevant information available
EXPOSURE CONTROLS/PERSONAL PROTECTIONAdditional information about design of technical systems: No further data; see item 7.
· Control parameters
· Components with limit values that require monitoring at the workplace: Not required.
· Additional information: The lists that were valid during the creation were used as basis.
· Exposure controls
· Personal protective equipment:
· General protective and hygienic measures:
Keep away from foodstuffs, beverages and feed.
Immediately remove all soiled and contaminated clothing.
Wash hands before breaks and at the end of work.
Avoid contact with the eyes and skin.
· Breathing equipment:
Not required.
Use suitable respiratory protective device in case of insufficient ventilation.
· Protection of hands:
The glove material has to be impermeable and resistant to the product/ the substance/ the preparation.
Selection of the glove material on consideration of the penetration times, rates of diffusion and the
degradation
The protective gloves to be used must comply with the specifications of EC Directive 89/686/EEC and the
related standard EN374
Protective gloves
· Material of gloves Butyl rubber, BR
· Penetration time of glove material
The exact break through time has to be found out by the manufacturer of the protective gloves and has to be
observed
Eye protection:
Tightly sealed goggles
PHYSICAL AND CHEMICAL PROPERTIESInformation on basic physical and chemical properties
· General Information
· Appearance:
Form: Solid
Color: Off white
· Odor: Odorless
· Odor threshold: Not determined.
· pH-value: Not applicable.
· Change in condition
Melting point/Melting range: >220 °C (>428 °F)
Boiling point/Boiling range: Not determined.
· Flash point: Not applicable.
· Flammability (solid, gaseous): Not determined.
· Ignition temperature: Not determined
· Decomposition temperature: Not determined.
· Auto igniting: Not determined.
· Danger of explosion: Not determined.
· Explosion limits:
Lower: Not determined.
Upper: Not determined.
· Vapor pressure: Not applicable.
· Density: Not determined.
· Relative density Not determined.
· Vapor density Not applicable.
· Evaporation rate Not applicable.
· Solubility in / Miscibility with
Water: Not determined.
· Partition coefficient (n-octanol/water): Not determined.
· Viscosity:
Dynamic: Not applicable.
(Contd. on page 6)
US
Kinematic: Not applicable.
· Other information No further relevant information available
STABILITY AND REACTIVITY Reactivity
Stable under normal conditions.
No further relevant information available.
· Chemical stability Stable under normal conditions.
· Thermal decomposition / conditions to be avoided:
Formation of toxic gases is possible during heating or in case of fire.
· Possibility of hazardous reactions No dangerous reactions known.
· Conditions to avoid Heat.
· Incompatible materials: Strong oxidizing agents.
· Hazardous decomposition products: Formation of toxic gases is possible during heating or in case of fire.
TOXICOLOGICAL INFORMATIONInformation on toxicological effects
· Acute toxicity:
· Primary irritant effect:
· on the skin: Irritant to skin and mucous membranes.
· on the eye: Causes serious eye irritation.
· Sensitization: Based on available data, the classification criteria are not met.
· Additional toxicological information:
· Carcinogenic categories
· IARC (International Agency for Research on Cancer) Substance is not listed.
· NTP (National Toxicology Program) Substance is not listed.
· OSHA-Ca (Occupational Safety & Health Administration) Substance is not listed.
· Carcinogenicity Suspected of causing cancer.
· Reproductive toxicity
Suspected of damaging fertility or the unborn child. May cause harm to breast-fed children.
ECOLOGICAL INFORMATION Toxicity
· Aquatic toxicity: No further relevant information available.
· Persistence and degradability No further relevant information available.
· Behavior in environmental systems:
· Bioaccumulative potential No further relevant information available.
· Mobility in soil No further relevant information available
DISPOSAL CONSIDERATIONS Waste treatment methods
· Recommendation:
Must not be disposed of together with household garbage. Do not allow product to reach sewage system.
· Uncleaned packagings:
· Recommendation: Dispose in accordance with national regulations.
TRANSPORT INFORMATIONUN-Number
· DOT, ADR, IMDG, IATA Not applicable
· DOT, ADR, IMDG, IATA Not applicable
· Transport hazard class(es)
· DOT, ADR, ADN, IMDG, IATA
· Class Not applicable
· Packing group
· DOT, ADR, IMDG, IATA Not applicable
· Environmental hazards: Not applicable.
· Special precautions for user Not applicable.
· Transport in bulk according to Annex II of
MARPOL73/78 and the IBC Code Not applicable.
· UN "Model Regulation": Not applicable
REGULATORY INFORMATIONSafety, health and environmental regulations/legislation specific for the substance or mixture
No further relevant information available.
· Sara
· Section 355 (extremely hazardous substances): Substance is not listed.
Section 313 (Specific toxic chemical listings): Substance is not listed.
· TSCA (Toxic Substances Control Act): Substance is not listed.
· Hazardous Air Pollutants Substance is not listed.
· Proposition 65
· Chemicals known to cause cancer: Substance is not listed.
· Chemicals known to cause reproductive toxicity for females: Substance is not listed.
· Chemicals known to cause reproductive toxicity for males: Substance is not listed.
· Chemicals known to cause developmental toxicity: Substance is not listed.
· Carcinogenic categories
· EPA (Environmental Protection Agency) Substance is not listed.
· TLV (Threshold Limit Value) Substance is not listed.
· NIOSH-Ca (National Institute for Occupational Safety and Health) Substance is not listed
Signal word Warning
· Hazard statements
H315 Causes skin irritation.
H319 Causes serious eye irritation.
H351 Suspected of causing cancer.
H361-H362 Suspected of damaging fertility or the unborn child. May cause harm to breast-fed children.
· Precautionary statements
P260 Do not breathe dusts or mists.
P263 Avoid contact during pregnancy/while nursing.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if
present and easy to do. Continue rinsing.
P405 Store locked up.
P501 Dispose of contents/container in accordance with local/regional/national/international
regulations.
· Chemical safety assessment: A Chemical Safety Assessment has not been carried out.
OTHER INFORMATIONThe above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any
guarantee of the properties of the product. For lab use only!