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Tigecycline

Item number676002
CAS220620-09-7
FormulaC29H39N5O8
Molecular weight585,65 g/mol
Quantity 1X25MG
storage conditions4 °C
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Tigecycline

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Safety Data Sheetaccording to Regulation (EC) No 1907/2006 (REACH)
Classifications according to Regulation (EC) No 1272/2008.
Printdate 20.04.2024
IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING
Product name:Tigecycline
Catalog No.:676002
Relevant identified uses of the substance or mixtureIdentified: Laboratory chemical
uses: R&D
Uses advised against:HPC Standards GmbH
Am Wieseneck 7

04451 Cunnersdorf
Deutschland


Tel. +49 34291 3372-36
Fax. +49 34291 3372-39
contact@hpc-standards.com
Emergency telephone numberHPC Standards Tel. +49 34291 3372-36
This number is only available during office hours.
HAZARDS IDENTIFICATION2.1 Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008
Eye irritation (Category 2), H319
Reproductive toxicity (Category 1B), H360FD
Specific target organ toxicity - repeated exposure (Category 1), Liver, Pancreas, Teeth,
Bone, H372
Long-term (chronic) aquatic hazard (Category 1), H410
For the full text of the H-Statements mentioned in this Section, see Section 16.
Label elements
PictogramGHS07 exclam
exclam
GHS08 silhouete
silhouete
GHS09 Aquatic-pollut-red
Aquatic-pollut-red
2.2 Label elements
Labelling according Regulation (EC) No 1272/2008
Pictogram
Signal Word Danger
Hazard statement(s)
H319 Causes serious eye irritation.
H360FD May damage fertility. May damage the unborn child.
H372 Causes damage to organs (Liver, Pancreas, Teeth, Bone)
through prolonged or repeated exposure.
H410 Very toxic to aquatic life with long lasting effects.
Precautionary statement(s)
P202 Do not handle until all safety precautions have been read and
understood.
P260 Do not breathe dust.
P264 Wash skin thoroughly after handling.
P273 Avoid release to the environment.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue
rinsing.
P308 + P313 IF exposed or concerned: Get medical advice/ attention.
Supplemental Hazard
Statements
none
Reduced Labeling (<= 125 ml)
Pictogram
Signal Word Danger
Hazard statement(s)
H372 Causes damage to organs through prolonged or repeated
exposure.
H360FD May damage fertility. May damage the unborn child.
Precautionary statement(s)
P202 Do not handle until all safety precautions have been read and
understood.
P260 Do not breathe dust.
P264 Wash skin thoroughly after handling.
P308 + P313 IF exposed or concerned: Get medical advice/ attention.
Supplemental Hazard
Statements
none
2.3 Other hazards
This substance/mixture contains no components considered to be either persistent,
bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at
levels of 0.1% or higher.
Caution: Physiologically highly active, therapeutically usable substance. The substance
must be handled with the care required for hazardous materials.
COMPOSITION/INFORMATION ON INGREDIENTS3.1 Substances
Formula : C6H8ClN3OS
Molecular weight : 585,65 g/mol
CAS-No. : 220620-09-7
Component: Tigecycline CAS-No. : 220620-09-7
Classification Eye Irrit. 2; Repr. 1B;
STOT RE 1; Aquatic Chronic 1; H319, H360FD, H372, H410 M-Factor - Aquatic Chronic: 1
Concentration: <= 100 %
For the full text of the H-Statements mentioned in this Section, see Section 16
FormulaC29H39N5O8
Molecular Weight (g/mol)585.65
CAS-No.220620-09-7
FIRST AID MEASURES4.1 Description of first-aid measures
General advice
Show this material safety data sheet to the doctor in attendance.
If inhaled
After inhalation: fresh air. Call in physician.
In case of skin contact
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with
water/ shower. Consult a physician.
In case of eye contact
After eye contact: rinse out with plenty of water. Call in ophthalmologist. Remove contact
lenses.
If swallowed
After swallowing: immediately make victim drink water (two glasses at most). Consult a
physician.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section
2.2) and/or in section 11
4.3 Indication of any immediate medical attention and special treatment needed
No data available
FIRE-FIGHTING MEASURES5.1 Extinguishing media
Suitable extinguishing media
Water Foam Carbon dioxide (CO2) Dry powder
Unsuitable extinguishing media
For this substance/mixture no limitations of extinguishing agents are given.
5.2 Special hazards arising from the substance or mixture
Carbon oxides
Nitrogen oxides (NOx)
Combustible
Combustible.
Development of hazardous combustion gases or vapours possible in the event of fire.
5.3 Advice for firefighters
Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by
keeping a safe distance or by wearing suitable protective clothing.
5.4 Further information
Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fire
extinguishing water from contaminating surface water or the ground water system.
ACCIDENTAL RELEASE MEASURES6.1 Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Avoid generation and inhalation of dusts in all
circumstances. Avoid substance contact. Ensure adequate ventilation. Evacuate the
danger area, observe emergency procedures, consult an expert.
For personal protection see section 8.
6.2 Environmental precautions
Do not let product enter drains.
6.3 Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions
(see sections 7 and 10). Take up carefully. Dispose of properly. Clean up affected area.
Avoid generation of dusts.
6.4 Reference to other sections
For disposal see section 13.
HANDLING AND STORAGE7.1 Precautions for safe handling
Advice on safe handling
Work under hood. Do not inhale substance/mixture.
Hygiene measures
Immediately change contaminated clothing. Apply preventive skin protection. Wash hands
and face after working with substance.
For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Storage conditions
Tightly closed. Dry. Keep in a well-ventilated place. Keep locked up or in an area accessible
only to qualified or authorized persons.
Storage stability
Recommended storage temperature
-20 - 0 °C
Storage class
Storage class (TRGS 510): 6.1D: Non-combustible, acute toxic Cat.3 / toxic hazardous
materials or hazardous materials causing chronic effects
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated
EXPOSURE CONTROLS/PERSONAL PROTECTION8.1 Control parameters
Ingredients with workplace control parameters
8.2 Exposure controls
Personal protective equipment
Eye/face protection
Use equipment for eye protection tested and approved under appropriate
government standards such as NIOSH (US) or EN 166(EU). Safety glasses
Skin protection
This recommendation applies only to the product stated in the safety data sheet,
supplied by us and for the designated use. When dissolving in or mixing with other
substances and under conditions deviating from those stated in EN374 please
contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell,
Internet: www.kcl.de).
Full contact
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Material tested:KCL 741 Dermatril® L
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Material tested:KCL 741 Dermatril® L
Body Protection
protective clothing
Respiratory protection
required when dusts are generated.
Our recommendations on filtering respiratory protection are based on the following
standards: DIN EN 143, DIN 14387 and other accompanying standards relating to
the used respiratory protection system.
Recommended Filter type: Filter type P3
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory
protective devices are carried out according to the instructions of the producer.
These measures have to be properly documented.
Control of environmental exposure
Do not let product enter drains.
PHYSICAL AND CHEMICAL PROPERTIES9.1 Information on basic physical and chemical properties
a) Physical state solid
b) Color orange
c) Odor No data available
d) Melting
point/freezing point
Melting point/range: 180 - 183 °C at 1.013 hPa
e) Initial boiling point
and boiling range
No data available
f) Flammability (solid,
gas)
The product is not flammable.
g) Upper/lower
flammability or
explosive limits
No data available
h) Flash point Not applicable
i) Autoignition
temperature
No data available
j) Decomposition
temperature
No data available
k) pH No data available
l) Viscosity Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
m) Water solubility at 20 °C soluble
n) Partition coefficient:
n-octanol/water
log Pow: 2,7 at 25 °C - Bioaccumulation is not expected., (Lit.)
o) Vapor pressure No data available
p) Density No data available
Relative density No data available
q) Relative vapor
density
No data available
r) Particle
characteristics
No data available
s) Explosive properties No data available
t) Oxidizing properties none
9.2 Other safety information
Solubility in other
solvents
dimethyl sulfoxide at 20 °C
- soluble
STABILITY AND REACTIVITY10.1 Reactivity
The following applies in general to flammable organic substances and mixtures: in
correspondingly fine distribution, when whirled up a dust explosion potential may generally
be assumed.
10.2 Chemical stability
The product is chemically stable under standard ambient conditions (room temperature) .
10.3 Possibility of hazardous reactions
Violent reactions possible with:
Strong oxidizing agents
10.4 Conditions to avoid
no information available
10.5 Incompatible materials
Strong oxidizing agents
10.6 Hazardous decomposition products
In the event of fire: see section 5
TOXICOLOGICAL INFORMATION11.1 Information on toxicological effects
Acute toxicity
Oral: No data available
Inhalation: No data available
Dermal: No data available
Skin corrosion/irritation
No data available
Serious eye damage/eye irritation
Eyes - Rabbit
Result: Severe irritations
Remarks: (External MSDS)
Respiratory or skin sensitization
Local lymph node assay (LLNA) - Mouse
Result: positive
Remarks: (External MSDS)
Germ cell mutagenicity
Test Type: Mutagenicity (mammal cell test): chromosome aberration.
Test system: Chinese hamster ovary cells
Result: negative
Remarks: (Lit.)
Test Type: In vitro mammalian cell gene mutation test
Test system: Mouse lymphoma test
Result: negative
Remarks: (Lit.)
Test Type: In vivo micronucleus test
Species: Mouse
Result: negative
Remarks: (Lit.)
Carcinogenicity
No data available
Reproductive toxicity
May damage the unborn child.
May damage fertility.
Specific target organ toxicity - single exposure
No data available
Specific target organ toxicity - repeated exposure
Causes damage to organs through prolonged or repeated exposure.
- Liver, Pancreas, Teeth, Bone
Aspiration hazard
No data available
11.2 Additional Information
Endocrine disrupting properties
Product:
Assessment : The substance/mixture does not contain
components considered to have endocrine
disrupting properties according to REACH Article
57(f) or Commission Delegated regulation (EU)
2017/2100 or Commission Regulation (EU)
2018/605 at levels of 0.1% or higher.
To the best of our knowledge, the chemical, physical, and toxicological properties have not
been thoroughly investigated.
To the best of our knowledge, the chemical, physical, and toxicological properties have not
been thoroughly investigated.
ECOLOGICAL INFORMATION12.1 Toxicity
Toxicity to fish LC50 - Pimephales promelas (fathead minnow) - 0,26 mg/l - 72 h
Remarks: (External MSDS)
Toxicity to daphnia
and other aquatic
invertebrates
EC50 - Daphnia magna (Water flea) - 2 mg/l - 48 h
Remarks: (External MSDS)
Toxicity to algae ErC50 - algae - 1,65 mg/l - 72 h
Remarks: (External MSDS)
Toxicity to
fish(Chronic toxicity)
NOEC - Pimephales promelas (fathead minnow) - 22 μg/l - 32 d
Remarks: (External MSDS)
Toxicity to daphnia
and other aquatic
invertebrates(Chronic
toxicity)
NOEC - Daphnia magna (Water flea) - 2,1 mg/l - 21 d
Remarks: (External MSDS)
12.2 Persistence and degradability
Biodegradability Result: - Not readily biodegradable.
12.3 Bioaccumulative potential
No data available
12.4 Mobility in soil
No data available
12.5 Results of PBT and vPvB assessment
This substance/mixture contains no components considered to be either persistent,
bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at
levels of 0.1% or higher.
12.6 Endocrine disrupting properties
Product:
Assessment : The substance/mixture does not contain components
considered to have endocrine disrupting properties
according to REACH Article 57(f) or Commission
Delegated regulation (EU) 2017/2100 or Commission
Regulation (EU) 2018/605 at levels of 0.1% or higher.
12.7 Other adverse effects
No data available
DISPOSAL CONSIDERATIONS13.1 Waste treatment methods
Product
See www.retrologistik.com for processes regarding the return of chemicals and
containers, or contact us there if you have further questions.
TRANSPORT INFORMATION14.1 UN number
ADR/RID: 3077 IMDG: 3077 IATA: 3077
14.2 UN proper shipping name
ADR/RID: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (Tigecycline)
IMDG: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (Tigecycline)
IATA: Environmentally hazardous substance, solid, n.o.s. (Tigecycline)
14.3 Transport hazard class(es)
ADR/RID: 9 IMDG: 9 IATA: 9
14.4 Packaging group
ADR/RID: III IMDG: III IATA: III
14.5 Environmental hazards
ADR/RID: yes IMDG Marine pollutant: yes IATA: yes
14.6 Special precautions for user
Tunnel restriction code : (-)
Further information
EHS-Mark required (ADR 2.2.9.1.10, IMDG code 2.10.3) for single packagings and
combination packagings containing inner packagings with Dangerous Goods > 5L for liquids
or > 5kg for solids.Packages smaller than or equal to 5 kg / L , not dangerous goods of
Class 9
REGULATORY INFORMATION15.1 Safety, health and environmental regulations/legislation specific for the
substance or mixture
This material safety data sheet complies with the requirements of Regulation (EC) No.
1907/2006.
National legislation
Seveso III: Directive 2012/18/EU of the European
Parliament and of the Council on the control of
major-accident hazards involving dangerous
substances.
: ENVIRONMENTAL HAZARDS
Other regulations
Observe work restrictions regarding maternity protection in accordance to Dir 92/85/EEC or
stricter national regulations where applicable.
Take note of Dir 94/33/EC on the protection of young people at work.
15.2 Chemical Safety Assessment
For this product a chemical safety assessment was not carried out
OTHER INFORMATIONThe above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any
guarantee of the properties of the product. For lab use only!