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Hexamethylene diisocyanate

Item number685917
CAS822-06-0
FormulaC8H12N2O2
Molecular weight168,19 g/mol
Quantity 1x250mg
storage conditions4 °C
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Hexamethylene diisocyanate

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Safety Data Sheetaccording to Regulation (EC) No 1907/2006 (REACH)
Classifications according to Regulation (EC) No 1272/2008.
Printdate 03.12.2022
IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING
Product name:Hexamethylene diisocyanate
Catalog No.:685917
Relevant identified uses of the substance or mixtureIdentified: Laboratory chemical
uses: R&D
Uses advised against:HPC Standards GmbH
Am Wieseneck 7

04451 Cunnersdorf
Deutschland


Tel. +49 34291 3372-36
Fax. +49 34291 3372-39
contact@hpc-standards.com
Emergency telephone numberHPC Standards Tel. +49 34291 3372-36
This number is only available during office hours.
HAZARDS IDENTIFICATION2.1 Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008
Acute toxicity, Oral (Category 4), H302
Acute toxicity, Inhalation (Category 3), H331
Acute toxicity, Inhalation (Category 1), H330
Skin corrosion (Category 1C), H314
Skin irritation (Category 2), H315
Eye irritation (Category 2), H319
Respiratory sensitisation (Category 1), H334
Skin sensitisation (Category 1), H317
Specific target organ toxicity - single exposure (Category 3), Respiratory system, H335
Label elements
PictogramGHS05 acid
acid
GHS06 skull
skull
GHS08 silhouete
silhouete
2.2 Label elements
Labelling according Regulation (EC) No 1272/2008
Pictogram Signal word Danger
Hazard statement(s)
H302 Harmful if swallowed.
H314 Causes severe skin burns and eye damage.
H315 Causes skin irritation.
H317 May cause an allergic skin reaction.
H330 Fatal if inhaled.
H331 Toxic if inhaled.
H334 May cause allergy or asthma symptoms or breathing difficulties
if inhaled.
H335 May cause respiratory irritation.
Precautionary statement(s)
P260 Do not breathe dust/ fume/ gas/ mist/ vapours/ spray.
P264 Wash skin thoroughly after handling.
P280 Wear protective gloves.
P304 + P340 + P310 IF INHALED: Remove person to fresh air and keep comfortable
for breathing. Immediately call a POISON CENTER/doctor.
P342 + P311 If experiencing respiratory symptoms: Call a POISON
CENTER/doctor.
P403 + P233 Store in a well-ventilated place. Keep container tightly closed.
Supplemental Hazard
Statements
none
2.3 Other hazards
This substance/mixture contains no components considered to be either persistent,
bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at
levels of 0.1% or higher.
Lachrymator., Rapidly absorbed through skin.
COMPOSITION/INFORMATION ON INGREDIENTS3.1 Substances
Synonyms : 1,6-Diisocyanatohexane
Formula : C8H12N2O2
Molecular weight : 168,19 g/mol
CAS-No. : 822-06-0
EC-No. : 212-485-8
Index-No. : 615-011-00-1
Component Classification Concentration
Hexamethylene diisocyanate
Acute Tox. 4; Acute Tox.
3; Acute Tox. 1; 1C; Skin
Irrit. 2; Eye Irrit. 2; Resp.
Sens. 1; Skin Sens. 1;
STOT SE 3; H302, H331,
<= 100 % H330, H314, H315, H319,
H334, H317, H335
Concentration limits:
>= 0,5 %: Resp. Sens. 1,
H334; >= 0,5 %: Skin
Sens. 1, H317;
FormulaC8H12N2O2
Molecular Weight (g/mol)168.19
CAS-No.822-06-0
FIRST AID MEASURES4.1 Description of first aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact
Take off contaminated clothing and shoes immediately. Wash off with soap and plenty of
water. Take victim immediately to hospital. Consult a physician.
In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If swallowed
Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse
mouth with water. Consult a physician.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section
2.2) and/or in section 11
4.3 Indication of any immediate medical attention and special treatment needed
No data available
FIRE-FIGHTING MEASURES5.1 Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
5.2 Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx)
5.3 Advice for firefighters
Wear self-contained breathing apparatus for firefighting if necessary.
5.4 Further information
No data available
ACCIDENTAL RELEASE MEASURES6.1 Personal precautions, protective equipment and emergency procedures
Wear respiratory protection. Avoid breathing vapours, mist or gas. Ensure adequate
ventilation. Evacuate personnel to safe areas.
For personal protection see section 8.
6.2 Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
Discharge into the environment must be avoided.
6.3 Methods and materials for containment and cleaning up
Soak up with inert absorbent material and dispose of as hazardous waste. Keep in
suitable, closed containers for disposal.
6.4 Reference to other sections
For disposal see section 13
HANDLING AND STORAGE7.1 Precautions for safe handling
Avoid contact with skin and eyes. Avoid inhalation of vapour or mist.
For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Keep container tightly closed in a dry and well-ventilated place. Containers which are
opened must be carefully resealed and kept upright to prevent leakage. Store in cool place.
Store under inert gas. Moisture sensitive.
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated
EXPOSURE CONTROLS/PERSONAL PROTECTION
PHYSICAL AND CHEMICAL PROPERTIES9.1 Information on basic physical and chemical properties
a) Appearance Form: liquid
b) Odour No data available
c) Odour Threshold No data available
d) pH No data available
e) Melting
point/freezing point
No data available
f) Initial boiling point
and boiling range
82 - 85 °C at 0,1 hPa
g) Flash point 130 °C - DIN 51755 Part 1
h) Evaporation rate No data available
i) Flammability (solid,
gas)
No data available j) Upper/lower
flammability or
explosive limits
Upper explosion limit: 9,5 %(V)
Lower explosion limit: 0,9 %(V)
k) Vapour pressure No data available
l) Vapour density No data available
m) Relative density 1,047 g/mL at 20 °C
n) Water solubility No data available
o) Partition coefficient:
n-octanol/water
No data available
p) Auto-ignition
temperature
No data available
q) Decomposition
temperature
No data available
r) Viscosity No data available
s) Explosive properties No data available
t) Oxidizing properties No data available
9.2 Other safety information
No data available
STABILITY AND REACTIVITY10.1 Reactivity
No data available
10.2 Chemical stability
Stable under recommended storage conditions.
10.3 Possibility of hazardous reactions
No data available
10.4 Conditions to avoid
Heat Avoid moisture.
10.5 Incompatible materials
No data available
10.6 Hazardous decomposition products
Hazardous decomposition products formed under fire conditions. - Carbon oxides, Nitrogen
oxides (NOx)
Other decomposition products - No data available
In the event of fire: see section 5
TOXICOLOGICAL INFORMATION11.1 Information on toxicological effects
Acute toxicity
LD50 Oral - Rat - male - 746 mg/kg
(OECD Test Guideline 401)
LC50 Inhalation - Rat - male and female - 4 h - 0,124 mg/l
(OECD Test Guideline 403)
LD50 Dermal - Rat - male and female - > 7.000 mg/kg
(OECD Test Guideline 402)
Skin corrosion/irritation
Skin - Rabbit
Result: Corrosive - 4 h
(OECD Test Guideline 404)
Serious eye damage/eye irritation
Eyes - Rabbit
Result: Causes serious eye damage.
(OECD Test Guideline 405)
Respiratory or skin sensitisation
Maximisation Test - Guinea pig
Result: positive
(OECD Test Guideline 406) Germ cell mutagenicity
Ames test
Salmonella typhimurium
Result: negative
(IUCLID)
Mutagenicity (mammal cell test):
Chinese hamster ovary cells
Result: negative
(Lit.)
OECD Test Guideline 474
Mouse - male and female - Bone marrow
Result: negative
Carcinogenicity
Carcinogenicity - Did not show carcinogenic effects in animal experiments.
IARC: No component of this product present at levels greater than or equal to 0.1% is
identified as probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
Specific target organ toxicity - single exposure
May cause respiratory irritation. - Respiratory system
Specific target organ toxicity - repeated exposure
Aspiration hazard
Additional Information
RTECS: MO1740000 burning sensation, Cough, wheezing, laryngitis, Shortness of breath, spasm, inflammation
and edema of the larynx, spasm, inflammation and edema of the bronchi, pneumonitis,
pulmonary edema, Material is extremely destructive to tissue of the mucous membranes
and upper respiratory tract, eyes, and skin., To the best of our knowledge, the chemical,
physical, and toxicological properties have not been thoroughly investigated.
ECOLOGICAL INFORMATION12.1 Toxicity
Toxicity to algae Growth inhibition ErC50 - Desmodesmus subspicatus (green algae) -
> 77,4 mg/l - 72 h
(OECD Test Guideline 201)
Growth inhibition NOEC - Desmodesmus subspicatus (green algae) -
11,7 mg/l - 72 h
(OECD Test Guideline 201)
Toxicity to bacteria Remarks: (IUCLID)(Hexamethylene diisocyanate)
12.2 Persistence and degradability
Biodegradability Result: 0 % - Not readily eliminated from water.
(OECD Test Guideline 302C)
aerobic - Exposure time 28 d
Result: 42 % - Not readily biodegradable.
(OECD Test Guideline 301F)
12.3 Bioaccumulative potential
12.4 Mobility in soil
12.5 Results of PBT and vPvB assessment
This substance/mixture contains no components considered to be either persistent,
bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at
levels of 0.1% or higher. 12.6 Other adverse effects
Harmful to aquatic life.
Stability in water - 5 - 10 min at 20 °C
Remarks: Hydrolyses on contact with water
DISPOSAL CONSIDERATIONS13.1 Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company. Waste material
must be disposed of in accordance with the Directive on waste 2008/98/EC as well as
other national and local regulations. Leave chemicals in original containers. No mixing
with other waste. Handle uncleaned containers like the product itself.
Contaminated packaging
Dispose of as unused product
TRANSPORT INFORMATION14.1 UN number
ADR/RID: 2281 IMDG: 2281 IATA: 2281
14.2 UN proper shipping name
ADR/RID: HEXAMETHYLENE DIISOCYANATE
IMDG: HEXAMETHYLENE DIISOCYANATE
IATA: Hexamethylene diisocyanate
14.3 Transport hazard class(es)
ADR/RID: 6.1 IMDG: 6.1 IATA: 6.1
14.4 Packaging group
ADR/RID: II IMDG: II IATA: II
14.5 Environmental hazards
ADR/RID: no IMDG Marine pollutant: no IATA: no
14.6 Special precautions for user
No data available
REGULATORY INFORMATION15.1 Safety, health and environmental regulations/legislation specific for the
substance or mixture
This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
15.2 Chemical safety assessment
For this product a chemical safety assessment was not carried out
OTHER INFORMATIONThe above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any
guarantee of the properties of the product. For lab use only!