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D6-Venlafaxine hydrochloride

Item number684743
FormulaC17H22ClD6NO2
Molecular weight319,90 g/mol
Quantity 1 ml
Concentration100 µg/ml
SolventMethanol
storage conditions20 °C
CoA / MSDSRetrieve CoA
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Show Safety Data Sheet online

Safety Data Sheetaccording to Regulation (EC) No 1907/2006 (REACH)
Printdate 25.04.2019
IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING
Product name:D6-Venlafaxine hydrochloride
Catalog No.:684743
Relevant identified uses of the substance or mixtureIdentified: Laboratory chemical
uses: R&D
Uses advised against:HPC Standards GmbH
Am Wieseneck 7

04451 Cunnersdorf
Deutschland


Tel. +49 34291 3372-36
Fax. +49 34291 3372-39
contact@hpc-standards.com
HAZARDS IDENTIFICATION2.1 Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008
Flammable liquids (Category 2), H225
Acute toxicity, Oral (Category 3), H301
Acute toxicity, Inhalation (Category 3), H331
Acute toxicity, Dermal (Category 3), H311
Specific target organ toxicity - single exposure (Category 1), H370
For the full text of the H-Statements mentioned in this Section, see Section 16.
Classification according to EU Directives 67/548/EEC or 1999/45/EC
F Highly flammable R11
T Toxic R23/24/25, R39/23/24/25
Label elementsLabelling according Regulation (EC) No 1272/2008 [CLP]
Pictogramflamme
flamme
GHS06 skull
skull
GHS08 silhouete
silhouete
Signal word Danger
Hazard statement(s)
H225 Highly flammable liquid and vapour.
H301 + H311 + H331 Toxic if swallowed, in contact with skin or if inhaled
H370 Causes damage to organs.
Precautionary statement(s)
P210 Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P260 Do not breathe dust/ fume/ gas/ mist/ vapours/ spray.
P280 Wear protective gloves/ protective clothing.
P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/
physician.
P311 Call a POISON CENTER or doctor/ physician.
Supplemental Hazard
Statements
none
2.3 Other hazards
This substance is not considered to be persistent, bioaccumulating nor toxic (PBT)., This substance is not
considered to be very persistent nor very bioaccumulating (vPvB).
COMPOSITION/INFORMATION ON INGREDIENTS3.1 Substances
Synonyms : Methyl alcohol
Formula : CH4O
Molecular Weight : 32,04 g/mol
CAS-No. : 67-56-1
EC-No. : 200-659-6
Index-No. : 603-001-00-X
Registration number : 01-2119433307-44-XXXX
Hazardous ingredients according to Regulation (EC) No 1272/2008
Component Classification Concentration
Methanol
CAS-No.
EC-No.
Index-No.
Registration number
67-56-1
200-659-6
603-001-00-X
01-2119433307-44-XXXX
Flam. Liq. 2; Acute Tox. 3;
STOT SE 1; H225, H301 +
H311 + H331, H370
<= 100 %
Hazardous ingredients according to Directive 1999/45/EC
Component Classification Concentration
Methanol
CAS-No.
EC-No.
Index-No.
Registration number
67-56-1
200-659-6
603-001-00-X
01-2119433307-44-XXXX
F, T, R11 - R23/24/25 -
R39/23/24/25
<= 100 %
FormulaC17H22ClD6NO2
Molecular Weight (g/mol)319.90
CAS-No.
FIRST AID MEASURES4.1 Description of first aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician.
In case of eye contact
Flush eyes with water as a precaution.
If swallowed
Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with
water. Consult a physician.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in
section 11
4.3 Indication of any immediate medical attention and special treatment needed
no data available
FIRE-FIGHTING MEASURES5.1 Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
5.2 Special hazards arising from the substance or mixture
Carbon oxides
5.3 Advice for firefighters
Wear self contained breathing apparatus for fire fighting if necessary.
5.4 Further information
Use water spray to cool unopened containers.
ACCIDENTAL RELEASE MEASURES6.1 Personal precautions, protective equipment and emergency procedures
Wear respiratory protection. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove
all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to form
explosive concentrations. Vapours can accumulate in low areas.
6.2 Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
6.3 Methods and materials for containment and cleaning up
Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and
place in container for disposal according to local regulations (see section 13).
6.4 Reference to other sections
For disposal see section 13.
HANDLING AND STORAGE7.1 Precautions for safe handling
Avoid contact with skin and eyes. Avoid inhalation of vapour or mist.
Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic
charge.
7.2 Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are
opened must be carefully resealed and kept upright to prevent leakage.
Recommended storage temperature: 2 - 8 °C
7.3 Specific end use(s)
no data available
EXPOSURE CONTROLS/PERSONAL PROTECTION8.1 Control parameters
Components with workplace control parameters
8.2 Exposure controls
Appropriate engineering controls
Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling
the product.
Personal protective equipment
Eye/face protection
Face shield and safety glasses Use equipment for eye protection tested and approved under
appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
(without touching glove's outer surface) to avoid skin contact with this product. Dispose of
contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
the standard EN 374 derived from it.
Body Protection
Complete suit protecting against chemicals, Flame retardant antistatic protective clothing, The type
of protective equipment must be selected according to the concentration and amount of the
dangerous substance at the specific workplace.
Respiratory protection
Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator
with multi-purpose combination (US) or type AXBEK (EN 14387) respirator cartridges as a backup
to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air
respirator. Use respirators and components tested and approved under appropriate government
standards such as NIOSH (US) or CEN (EU).
PHYSICAL AND CHEMICAL PROPERTIES9.1 Information on basic physical and chemical properties
a) Appearance Form: liquid
Colour: colourless
b) Odour pungent
c) Odour Threshold no data available
d) pH no data available
e) Melting point/freezing
point
Melting point/range: -98 °C
f) Initial boiling point and
boiling range
64,7 °C
g) Flash point 9,7 °C - closed cup
h) Evapouration rate no data available
i) Flammability (solid, gas) no data available
j) Upper/lower
flammability or
explosive limits
Upper explosion limit: 36 %(V)
Lower explosion limit: 6 %(V)
k) Vapour pressure 130,3 hPa at 20,0 °C
546,6 hPa at 50,0 °C
169,27 hPa at 25,0 °C
l) Vapour density 1,11
m) Relative density 0,791 g/mL at 25 °C
n) Water solubility completely miscible
o) Partition coefficient: noctanol/
water
log Pow: -0,77
p) Auto-ignition
temperature
455,0 °C at 1.013 hPa
q) Decomposition
temperature
no data available
r) Viscosity no data available
s) Explosive properties Not explosive
t) Oxidizing properties The substance or mixture is not classified as oxidizing.
9.2 Other safety information
Minimum ignition energy 0,14 mJ
Conductivity < 1 &#956;S/cm
Relative vapour density 1,11
STABILITY AND REACTIVITY10.1 Reactivity
no data available
10.2 Chemical stability
no data available
10.3 Possibility of hazardous reactions
no data available
10.4 Conditions to avoid
Heat, flames and sparks. Extremes of temperature and direct sunlight.
10.5 Incompatible materials
Acids, Oxidizing agents, Alkali metals, Acid chlorides, Acid anhydrides, Reducing agents
10.6 Hazardous decomposition products
Other decomposition products - no data available
TOXICOLOGICAL INFORMATION11.1 Information on toxicological effects
Acute toxicity
LDLO Oral - Human - 143 mg/kg
Remarks: Lungs, Thorax, or Respiration:Dyspnea. Ingestion may cause gastrointestinal irritation, nausea,
vomiting and diarrhoea.
LD50 Oral - rat - 1.187 - 2.769 mg/kg
LC50 Inhalation - rat - 4 h - 128,2 mg/l
LC50 Inhalation - rat - 6 h - 87,6 mg/l
LD50 Dermal - rabbit - 17.100 mg/kg
Skin corrosion/irritation
Skin - rabbit
Result: No skin irritation
Serious eye damage/eye irritation
Eyes - rabbit
Result: No eye irritation
Respiratory or skin sensitisation
Maximisation Test - guinea pig
Does not cause skin sensitisation.
(OECD Test Guideline 406)
Germ cell mutagenicity
Ames test
S. typhimurium
Result: negative
in vitro assay
fibroblast
Result: negative
Mutation in mammalian somatic cells.
Mutagenicity (in vivo mammalian bone-marrow cytogenetic test, chromosomal analysis)
mouse - male and female
Result: negative
Carcinogenicity
IARC: No component of this product present at levels greater than or equal to 0.1% is identified as
probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
Damage to fetus not classifiable
Fertility classification not possible from current data.
Specific target organ toxicity - single exposure
Causes damage to organs.
Specific target organ toxicity - repeated exposure
The substance or mixture is not classified as specific target organ toxicant, repeated exposure.
Aspiration hazard
No aspiration toxicity classification
Additional Information
RTECS: PC1400000
Methyl alcohol may be fatal or cause blindness if swallowed.
Effects due to ingestion may include:, Headache, Dizziness, Drowsiness, metabolic acidosis, Coma,
Seizures.
Symptoms may be delayed., Damage of the:, Liver, Kidney
ECOLOGICAL INFORMATION12.1 Toxicity
no data available
12.2 Persistence and degradability
no data available
12.3 Bioaccumulative potential
no data available
12.4 Mobility in soil
no data available
12.5 Results of PBT and vPvB assessment
no data available
12.6 Other adverse effects
no data available
DISPOSAL CONSIDERATIONS13.1 Waste treatment methods
Product
Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting
as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal
company.
Contaminated packaging
Dispose of as unused product.
TRANSPORT INFORMATION14.1 UN number
ADR/RID: 1230 IMDG: 1230 IATA: 1230
14.2 UN proper shipping name
ADR/RID: METHANOL
IMDG: METHANOL
IATA: Methanol
14.3 Transport hazard class(es)
ADR/RID: 3 (6.1) IMDG: 3 (6.1) IATA: 3 (6.1)
14.4 Packaging group
ADR/RID: II IMDG: II IATA: II
14.5 Environmental hazards
ADR/RID: no IMDG Marine Pollutant: no IATA: no
14.6 Special precautions for user
no data available
REGULATORY INFORMATIONThis safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
no data available
15.2 Chemical Safety Assessment
no data available
OTHER INFORMATIONThe above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any
guarantee of the properties of the product. For lab use only!