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D3-Cholecalciferol

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Item number690245
CAS80666-48-4
FormulaC27H41D3O
Molecular weight387,66 g/mol
Quantity 1X1ML
Concentration100 µg/ml
SolventEthanol
storage conditions-20 °C
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D3-Cholecalciferol

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Safety Data Sheetaccording to Regulation (EC) No 1907/2006 (REACH)
Classifications according to Regulation (EC) No 1272/2008.
Printdate 19.04.2024
IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING
Product name:D3-Cholecalciferol
Catalog No.:690245
Relevant identified uses of the substance or mixtureIdentified: Laboratory chemical
uses: R&D
Uses advised against:HPC Standards GmbH
Am Wieseneck 7

04451 Cunnersdorf
Deutschland


Tel. +49 34291 3372-36
Fax. +49 34291 3372-39
contact@hpc-standards.com
Emergency telephone numberHPC Standards Tel. +49 34291 3372-36
This number is only available during office hours.
HAZARDS IDENTIFICATION2.1 Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008
Flammable liquids (Category 2), H225
Eye irritation (Category 2), H319
Label elements
Pictogramflamme
flamme
GHS07 exclam
exclam
2.2 Label elements
Labelling according Regulation (EC) No 1272/2008
Pictogram Signal word Danger
Hazard statement(s)
H225 Highly flammable liquid and vapour.
H319 Causes serious eye irritation.
Precautionary statement(s)
P210 Keep away from heat, hot surfaces, sparks, open flames and other
ignition sources. No smoking. P280 Wear eye protection/ face protection.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove
contact lenses, if present and easy to do. Continue rinsing.
P337 + P313 If eye irritation persists: Get medical advice/ attention.
P403 + P235 Store in a well-ventilated place. Keep cool.
Supplemental Hazard
Statements
none
2.3 Other hazards
This substance/mixture contains no components considered to be either persistent, bioaccumulative and
toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher
COMPOSITION/INFORMATION ON INGREDIENTS3.1 Substances
Synonyms : Ethyl alcohol
Formula : C2H6O
Molecular weight : 46,07 g/mol
CAS-No. : 64-17-5
EC-No. : 200-578-6
Index-No. : 603-002-00-5
Registration number : 01-2119457610-43-XXXX
Hazardous ingredients according to Regulation (EC) No 1272/2008
Component Classification Concentration
Ethanol
CAS-No.
EC-No.
Index-No.
64-17-5
200-578-6
603-002-00-5
Flam. Liq. 2; Eye Irrit. 2; H225,
H319
Concentration limits:
>= 50 %: Eye Irrit. 2A, H319;
<= 100 %
FormulaC27H41D3O
Molecular Weight (g/mol)387.66
CAS-No.80666-48-4
FIRST AID MEASURES4.1 Description of first aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Consult a physician.
In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If swallowed
Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with
water. Consult a physician.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in
section 11
4.3 Indication of any immediate medical attention and special treatment needed
No data available
FIRE-FIGHTING MEASURES5.1 Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
5.2 Special hazards arising from the substance or mixture
Carbon oxides
5.3 Advice for firefighters
Wear self-contained breathing apparatus for firefighting if necessary.
5.4 Further information
Use water spray to cool unopened containers
ACCIDENTAL RELEASE MEASURES6.1 Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid breathing vapours, mist or gas. Ensure adequate ventilation.
Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to
form explosive concentrations. Vapours can accumulate in low areas.
For personal protection see section 8.
6.2 Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
6.3 Methods and materials for containment and cleaning up
Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and
place in container for disposal according to local regulations (see section 13).
6.4 Reference to other sections
For disposal see section 13.
HANDLING AND STORAGE7.1 Precautions for safe handling
Avoid contact with skin and eyes. Avoid inhalation of vapour or mist.
Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic
charge.
For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are
opened must be carefully resealed and kept upright to prevent leakage.
Hygroscopic.
Storage class (TRGS 510): Flammable liquids
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated
EXPOSURE CONTROLS/PERSONAL PROTECTION8.1 Control parameters
Components with workplace control parameters
Derived No Effect Level (DNEL)
Application Area Exposure
routes
Health effect Value
Workers Inhalation Long-term systemic effects 950 mg/m3
Workers Skin contact Long-term systemic effects 343mg/kg BW/d
Workers Ingestion Long-term systemic effects 343mg/kg BW/d
Workers Inhalation Acute local effects 1900 mg/m3 Predicted No Effect Concentration (PNEC)
Compartment Value
Soil 0,63 mg/kg
Marine water 0,79 mg/l
Fresh water 0,96 mg/l
Fresh water sediment 3,6 mg/l
Sewage treatment plant 580 mg/l
8.2 Exposure controls
Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and
at the end of workday.
Personal protective equipment
Eye/face protection
Face shield and safety glasses Use equipment for eye protection tested and approved under
appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
(without touching glove's outer surface) to avoid skin contact with this product. Dispose of
contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands. Body Protection
impervious clothing, Flame retardant antistatic protective clothing., The type of protective
equipment must be selected according to the concentration and amount of the dangerous
substance at the specific workplace.
Respiratory protection
Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator
with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup
to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air
respirator. Use respirators and components tested and approved under appropriate government
standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so. Do not let product enter drains
PHYSICAL AND CHEMICAL PROPERTIES9.1 Information on basic physical and chemical properties
a) Appearance Form: liquid, clear
Colour: colourless
b) Odour No data available
c) Odour Threshold No data available
d) pH No data available
e) Melting point/freezing
point
-143,99 °C
f) Initial boiling point and
boiling range
78,0 - 80,0 °C
g) Flash point 14,0 °C - closed cup
h) Evaporation rate No data available
i) Flammability (solid, gas) No data available
j) Upper/lower
flammability or
explosive limits
Upper explosion limit: 19 %(V)
Lower explosion limit: 3,3 %(V)
k) Vapour pressure 59,5 hPa at 20,0 °C
l) Vapour density No data available
m) Relative density 0,7974 g/cm3
n) Water solubility completely soluble
o) Partition coefficient: noctanol/
water
log Pow: -0,349 at 24 °C
p) Auto-ignition
temperature
363,0 °C
q) Decomposition
temperature
No data available
r) Viscosity No data available
s) Explosive properties No data available
t) Oxidizing properties No data available 9.2 Other safety information
No data available
STABILITY AND REACTIVITY10.1 Reactivity
No data available
10.2 Chemical stability
Stable under recommended storage conditions.
10.3 Possibility of hazardous reactions
No data available
10.4 Conditions to avoid
Heat, flames and sparks.
10.5 Incompatible materials
Alkali metals, Oxidizing agents, Peroxides 10.6 Hazardous decomposition products
Other decomposition products - No data available
In the event of fire: see section 5
TOXICOLOGICAL INFORMATION11.1 Information on toxicological effects
Acute toxicity
LD50 Oral - Rat - 10.470 mg/kg
LC50 Inhalation - Rat - 4 h - 30.000 mg/l
LD50 Dermal - Rabbit - 15.800 mg/kg
Skin corrosion/irritation
Skin - Rabbit
Result: No skin irritation - 24 h
(OECD Test Guideline 404)
Serious eye damage/eye irritation
Eyes - Rabbit
Result: Moderate eye irritation
(OECD Test Guideline 405)
Respiratory or skin sensitisation
No data available
Germ cell mutagenicity
No data available
Carcinogenicity
Carcinogenicity - Mouse - Oral
Tumorigenic:Equivocal tumorigenic agent by RTECS criteria. Liver:Tumors. Blood:Lymphomas including
Hodgkin's disease.
IARC: No component of this product present at levels greater than or equal to 0.1% is identified as
probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
Reproductive toxicity - Human - female - Oral
Effects on Newborn: Apgar score (human only). Effects on Newborn: Other neonatal measures or effects.
Effects on Newborn: Drug dependence.
Specific target organ toxicity - single exposure
No data available Specific target organ toxicity - repeated exposure
No data available
Aspiration hazard
No data available
Additional Information
RTECS: KQ6300000
Central nervous system depression, narcosis, Damage to the heart., To the best of our knowledge, the
chemical, physical, and toxicological properties have not been thoroughly investigated
ECOLOGICAL INFORMATION12.1 Toxicity
Toxicity to fish LC50 - Pimephales promelas (fathead minnow) - 14.200 mg/l - 96 h
Toxicity to daphnia and
other aquatic
LC50 - Ceriodaphnia dubia (water flea) - 5.012 mg/l - 48 h invertebrates
NOEC - Daphnia magna (Water flea) - 9,6 mg/l - 9 d
Toxicity to algae EC50 - Chlorella vulgaris (Fresh water algae) - 275 mg/l - 72 h
(OECD Test Guideline 201)
12.2 Persistence and degradability
Biodegradability Result: 95 % - Readily biodegradable
12.3 Bioaccumulative potential
Due to the distribution coefficient n-octanol/water, accumulation in organisms is not expected.
12.4 Mobility in soil
No data available
12.5 Results of PBT and vPvB assessment
This substance/mixture contains no components considered to be either persistent, bioaccumulative and
toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
12.6 Other adverse effects
No data available
DISPOSAL CONSIDERATIONS13.1 Waste treatment methods
Product
Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting
as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal
company.
Contaminated packaging
Dispose of as unused product
TRANSPORT INFORMATION14.1 UN number
ADR/RID: 1170 IMDG: 1170 IATA: 1170
14.2 UN proper shipping name
ADR/RID: ETHANOL
IMDG: ETHANOL
IATA: Ethanol
14.3 Transport hazard class(es)
ADR/RID: 3 IMDG: 3 IATA: 3
14.4 Packaging group
ADR/RID: II IMDG: II IATA: II
14.5 Environmental hazards
ADR/RID: no IMDG Marine pollutant: no IATA: no
14.6 Special precautions for user
No data available
REGULATORY INFORMATIONThis safety datasheet complies with the requirements of Regulation (EC) No. 453/2010.
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
15.2 Chemical Safety Assessment
A Chemical Safety Assessment has been carried out for this substance
OTHER INFORMATIONThe above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any
guarantee of the properties of the product. For lab use only!