Clozapine Reference Materials

Clozapine Reference Materials for Precise Residue Analysis

Unlock the highest standards in residue analysis with our high-purity Clozapine reference materials. Essential for laboratories focused on food and environmental analysis, our products ensure compliance with stringent regulatory limits. Trust HPC Standards GmbH for reliable and accurate results.

Product		Catalog No./ CAS No.	Quantity	Price
Clozapine		681004 5786-21-0	1X25MG	Please log in.
D4-Clozapine solution Concentration: 100 µg/ml Solvent: Methanol		684072 204395-52-8	1X1ML	On request

High-quality reference materials for accurate and reliable residue analysis of Clozapine.

Overview

Clozapine is a psychiatric medication and the first atypical antipsychotic discovered. It is primarily used to treat schizophrenia and schizoaffective disorder in patients who have not responded adequately to other antipsychotics. It is also used for treating psychosis in Parkinson's disease.

Uses

Clozapine is recommended for patients with schizophrenia or schizoaffective disorder who have not responded to two other antipsychotics. It is also used to treat psychosis in Parkinson's disease and is the only antipsychotic known to reduce the risk of suicide in these patients.

Regulatory

Clozapine is regulated as a prescription-only medication in many countries. In the US, it has a black box warning for several severe side effects, including agranulocytosis and myocarditis. It is listed on the World Health Organization's List of Essential Medicines.

Monitoring

Patients prescribed clozapine require regular blood monitoring due to the risk of agranulocytosis. Full blood counts are typically performed weekly for the first 18 weeks, then less frequently thereafter. Monitoring of other parameters such as weight, blood pressure, and markers for myocarditis is also recommended.

Health Impact

Clozapine has a range of side effects, including drowsiness, constipation, hypersalivation, tachycardia, and weight gain. It is not commonly associated with tardive dyskinesia but can cause agranulocytosis, seizures, myocarditis, and hyperglycemia.

Human Toxicity

Potential adverse effects include agranulocytosis, seizures, myocarditis, and hyperglycemia. The use of clozapine can rarely result in clozapine-induced gastric hypomotility syndrome, which may lead to bowel obstruction and death.

Environmental Impact

The environmental impact of clozapine includes its effects on wildlife, particularly through contamination of water sources. Proper disposal and management of clozapine waste are essential to mitigate these effects.

Effects on Wildlife

Contaminants from clozapine can affect aquatic life and other wildlife. It is crucial to manage and dispose of clozapine waste properly to prevent environmental contamination.

Safety Measures

Strict monitoring and management protocols are in place to ensure the safe use of clozapine. These include regular blood tests, monitoring for signs of myocarditis, and managing side effects through dose adjustments and additional medications.

Regulation

Clozapine is regulated under various national and international guidelines. In the US, it is available only through a restricted program due to its severe side effects. Similar regulations exist in other countries to ensure patient safety.

Analytical Standards

HPC Standards GmbH provides high-purity reference materials for clozapine, ensuring accurate and reliable residue analysis. These reference materials meet international quality requirements and the highest industrial standards, essential for laboratories conducting food and environmental analysis to ensure compliance with regulatory limits.

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