Trimethoprim Reference Materials

Ensure Accurate Residue Analysis with High-Purity Trimethoprim Reference Materials

HPC Standards GmbH offers top-tier Trimethoprim reference materials, meticulously tested to meet international quality standards. Essential for laboratories focused on food and environmental analysis, our products guarantee precise and reliable results, ensuring compliance with regulatory limits. Partner with us for unparalleled expertise in high-purity analytical standards.

Product	Catalog No./ CAS No.	Quantity	Price
13C3-Trimethoprim	690407 1189970-95-3	1X10MG	Please log in.
13C3-Trimethoprim solution Concentration: 100 µg/ml Solvent: Acetonitrile	690443 1189970-95-3	1X1ML	Please log in.
D9-Trimethoprim	679828 1189460-62-5	1X10MG	Please log in.
D9-Trimethoprim solution Concentration: 100 µg/ml Solvent: Methanol	687614 1189460-62-5	1X1ML	Please log in.
ISO 17034 Reference Material Trimethoprim	672980 738-70-5	1X250MG	Please log in.
Trimethoprim solution Concentration: 100 µg/ml Solvent: Methanol	679824 738-70-5	1X1ML	Please log in.
ISO 17034 Certified Reference Material Trimethoprim	691054 738-70-5	1X100MG	Please log in.

High-purity reference materials for accurate and reliable residue analysis of Trimethoprim.

Overview

Trimethoprim is an antibiotic primarily used to treat bladder infections, middle ear infections, and travelers' diarrhea. It is also used in combination with sulfamethoxazole or dapsone for the treatment of Pneumocystis pneumonia in individuals with HIV/AIDS. Trimethoprim works by inhibiting bacterial dihydrofolate reductase, leading to the prevention of bacterial DNA and RNA synthesis.

Uses

Trimethoprim is mainly used for the treatment of urinary tract infections and can be effective against various aerobic bacterial species. It is also employed in the prevention and treatment of Pneumocystis jirovecii pneumonia. However, it is generally not recommended for anaerobic infections such as Clostridium difficile colitis.

Regulatory

Trimethoprim is available only by prescription in many countries, including Australia (S4), Canada (℞-only), the UK (POM), and the US (℞-only). It is listed on the World Health Organization's List of Essential Medicines and is available as a generic medication.

Monitoring

It is crucial to perform cultures and susceptibility tests to ensure that the bacteria are susceptible to trimethoprim. This helps in effective treatment and prevents resistance development.

Health Impact

Human Toxicity

Common side effects include nausea, changes in taste, rash, vomiting, diarrhea, sun sensitivity, and itchiness. Rare side effects include blood problems such as thrombocytopenia and megaloblastic anemia, hyperkalemia, and artificial rise in serum creatinine levels. Trimethoprim may also increase the expression of Shiga toxin in EHEC infections.

Environmental Impact

Effects on Wildlife

As an antibiotic, trimethoprim can potentially affect aquatic and terrestrial ecosystems if not properly managed. Monitoring and regulation are essential to mitigate its environmental impact.

Safety Measures

Trimethoprim should be used with caution in individuals with known hypersensitivity to the drug or a history of megaloblastic anemia due to folate deficiency. It is also advised to avoid alcohol consumption during treatment, especially when used in combination with sulfamethoxazole.

Regulation

Trimethoprim is regulated under prescription-only status in various countries. It is essential to comply with local regulatory requirements for its use and distribution.

Analytical Standards

HPC Standards GmbH provides high-purity reference materials for Trimethoprim to ensure accurate and reliable residue analysis. Our products meet international quality requirements and the highest industrial standards, making them essential for laboratories conducting food and environmental analysis to ensure compliance with regulatory limits.

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