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Bisphenol F (BPF) Reference Materials
Bisphenol F High-Purity Reference Materials for Confident Compliance
Achieve precise, traceable quantification of Bisphenol F isomers with HPC Standards. Our high-purity BPF reference materialsavailable as neat 4,4-, 2,4-, 2,2-isomers, isomeric mixes, and ready-to-use solutionsare manufactured to international quality requirements and supplied with comprehensive CoAs. Strengthen LCMSMS and GCMS workflows with isotope-labeled internal standards, matrix-matched calibration options, and custom multi-analyte blends. Ideal for food-contact migration studies, water monitoring, and industrial QC, our standards support ISOIEC 17025-compliant methods, delivering accuracy, stability, and reliable reporting across complex matrices.
Product | Catalog No./ CAS No. | Quantity | Price | |
|---|---|---|---|---|
 | 693431 | 1X5MG | ||
13C12-Bisphenol F solution |  | 693432 | 1X1ML | |
ISO 17034 Reference Material |  | 674795 | 1X100MG | Please log in. |
ISO 17034 Certified Reference Material |  | 694333 | 1X50MG | Please log in. |
High-purity reference materials for precise quantification of Bisphenol F isomers in food-contact, environmental, and industrial matrices. Manufactured and tested to international quality requirements for rigorous regulatory compliance and method validation.
Overview
Bisphenol F (BPF) is an industrial chemical used primarily in epoxy resin systems, coatings, adhesives, and as a partial substitute for Bisphenol A (BPA). BPF commonly occurs as a mixture of positional isomers (4,4'-, 2,4'-, 2,2'-). Due to its phenolic structure, BPF can migrate from materials into foods and the environment, necessitating reliable monitoring and quantification.
Chemical Identity and Properties
- Synonyms: 4,4'-Dihydroxydiphenylmethane; Bis(4-hydroxyphenyl)methane (for the 4,4'-isomer); Bisphenol F (mixture of isomers)
- Representative CAS (4,4'-BPF): 620-92-8; Isomeric BPF mixture CAS is used in commerce; specific isomers have distinct CAS numbers.
- Molecular formula: C13H12O2; Molecular weight (4,4'-BPF): ~200.23 g/mol
- Functional groups: Two phenolic hydroxyls; weakly acidic (phenolic pKa in the ~9–10 range)
- Physicochemical notes: Moderate hydrophobicity (log Kow in the low-to-mid 3 range for the 4,4'-isomer); low volatility; amenable to LC–MS/MS determination.
Uses and Sources
- Precursor and monomer in epoxy resins and phenolic resins
- Present in coatings, adhesives, composite materials, and industrial sealants
- Potential contaminant in recycled materials and manufacturing effluents
- Possible occurrence as an impurity or degradation product in polymeric systems
Regulatory Landscape
- European Union: BPF is monitored within the framework of REACH and food-contact materials legislation. While harmonized EU-wide specific migration limits are established for BPA, BPF regulations are evolving; some national or sector-specific guidance values and monitoring programs may apply.
- United States: Listed on the TSCA Inventory; regulatory oversight focuses on exposure assessment and risk evaluation. FDA restrictions explicitly target BPA in certain applications; BPF usage and migration are subject to general safety and compliance requirements.
- Global: Growing scrutiny as a BPA alternative; sector- and country-specific limits or recommendations may apply, particularly for food-contact and drinking water materials. Laboratories should consult the latest jurisdictional guidance for limits and reporting requirements.
Monitoring and Occurrence
- Matrices: Food-contact material migration simulants, finished foods, drinking and surface waters, wastewater (influent/effluent), sediments, indoor dust, and industrial samples
- Sampling considerations: Minimize phenolic contamination; use glassware rinsed with suitable solvents; avoid polymeric caps/liners prone to leaching
- Typical concentration ranges: Environmental samples often at ng/L to low µg/L; migration studies depend on polymer type, conditions, and simulant
Health Impact
- Human toxicity: BPF exhibits endocrine-active properties in experimental systems, with activity reported in a similar order of magnitude to BPA for certain endpoints. Toxicokinetics indicate phase II conjugation (e.g., glucuronidation) and urinary excretion of conjugates.
- Exposure routes: Dietary intake via migration from materials, environmental exposure through water and dust, and occupational exposure in manufacturing/processing settings.
- Risk assessment: Ongoing evaluations by authorities and research organizations; laboratories support risk characterization through accurate occurrence data.
Environmental Impact
- Fate and transport: Low volatility; partitioning to solids and organic phases; potential persistence in sediments depending on conditions
- Degradation: Biotic and abiotic transformation possible; rates vary with matrix and environmental parameters
- Effects on wildlife: Endocrine-related effects have been reported in aquatic test systems; sensitivity varies by species and life stage
Safety Measures and Handling
- Handle BPF and solutions with appropriate PPE (lab coat, gloves, eye protection); avoid skin contact and inhalation of aerosols
- Work in well-ventilated areas or fume hoods; prevent contamination of samples and surfaces
- Follow SDS guidance for storage, spill response, and disposal according to local regulations
Analytical Methods
- Preferred techniques: LC–MS/MS (ESI negative mode commonly used for phenolics), HPLC-UV/FLD for screening; GC–MS after derivatization (e.g., silylation with MSTFA/BSTFA)
- Sample preparation: SPE (e.g., polymeric sorbents) for waters; QuEChERS adaptations for complex food and environmental matrices; enzymatic deconjugation steps for biomonitoring (as applicable)
- Key performance parameters: Low ng/L to µg/L LOQs depending on matrix; include isotopically labeled internal standards for quantitation and matrix-effect compensation
Reference Materials from HPC Standards
- Product scope: Neat BPF isomers (4,4'-, 2,4'-, 2,2'-), BPF isomeric mixtures, and ready-to-use calibrated solutions across relevant concentration ranges
- Isotope-labeled options: Stable isotope-labeled BPF internal standards available or on request to strengthen quantitative accuracy
- Matrices and solvents: High-purity solutions in acetonitrile, methanol, or toluene; custom blends and multi-analyte mixes tailored to method panels (e.g., bisphenols set)
- Documentation: Each lot supplied with a comprehensive Certificate of Analysis (purity, identity, uncertainty, traceability), Safety Data Sheet, and shelf-life/stability information
Applications
- Method development and validation (linearity, precision, trueness, recovery, LOQ) for LC–MS/MS and GC–MS workflows
- Routine QC: Calibration, system suitability, and ongoing performance verification in accredited laboratories
- Compliance testing: Food-contact migration studies, environmental monitoring (surface/drinking water, wastewater), and industrial hygiene programs
Quality and Accreditation
- Manufactured under stringent quality controls aligned with international requirements; products designed to support ISO/IEC 17025 workflows
- Property values assigned with traceability to SI where applicable; measurement uncertainty reported on the CoA
- Batch-specific homogeneity and stability assessments ensure consistent performance
Storage and Stability
- Recommended storage: Refrigerated (e.g., 2–8 °C) or as stated on label/CoA; protect from light and moisture
- Use clean glassware and pre-rinsed caps; minimize freeze–thaw cycles; document opening dates for solution standards
Method Compliance and Reporting
- Align with relevant guidance (e.g., SANTE/ISO/ASTM methods) for validation and reporting
- Employ isotopically labeled internal standards and matrix-matched calibration where appropriate
- Report isomer-specific results when required; clearly state analyte definition (single isomer vs. sum of isomers)
Related Compounds
- Bisphenol A (BPA), Bisphenol S (BPS), and additional bisphenol analogues frequently included in multi-residue panels
- Consider cross-contamination control and chromatographic resolution among bisphenols and matrix interferences
Ordering Information
- Formats: Neat materials and ampouled solutions at multiple concentrations; custom mixes upon request
- Packaging: Amber glass ampoules or vials to mitigate photodegradation; tamper-evident labeling
- Support: Technical consultation for method setup, isomer selection, and custom calibration solutions