New user? / Forgot your password?
0 Item | 0,00 €
Metalaxyl Metabolite CGA 226048 – Reference Materials
Metalaxyl Metabolite CGA 226048 High-Purity Reference Standards for Confident Compliance
Ensure precise, reproducible LCMSMS quantification of CGA 226048 with HPC Standards expertly manufactured reference materials. Our solutions and neat materials are gravimetrically prepared, purity-characterized, and fully documented CoA, SDS, uncertainty, SI traceability to support calibration, matrix-matched quantification, identity confirmation, and method validation across food and environmental matrices. Benefit from robust quality control, short lead times, and custom optionsincluding multi-analyte mixes with MetalaxylMetalaxylM and isotope-labelled analogsfor streamlined regulatory monitoring and ISOIEC 17025 workflows. Rely on HPC Standards for accuracy, traceability, and regulatory confidence.
Product | Catalog No./ CAS No. | Quantity | Price | |
|---|---|---|---|---|
 | 692850 | 1X10MG | ||
(R,S)-Metalaxyl Metabolite CGA 226048 solution |  | 692851 | 1X1ML | |
 | 692848 | 1X10MG | ||
(S,S)-Metalaxyl Metabolite CGA 226048 solution |  | 692849 | 1X1ML |
High-precision reference materials for Metalaxyl metabolite CGA 226048 to support compliant residue analysis in food and environmental matrices. Manufactured by HPC Standards with full documentation, traceability, and robust quality control.
Overview
CGA 226048 is a known transformation product (metabolite) of the systemic phenylamide fungicide Metalaxyl. It is formed through metabolic and environmental degradation pathways and may be relevant for residue definitions, risk assessment, and method validation in regulatory monitoring.
Due to differing persistence and polarity compared to the parent compound, CGA 226048 can influence overall residue profiles and must be considered in comprehensive multi-residue methods.
Chemical Identity and Formation
CGA 226048 is generated from Metalaxyl via phase I reactions (e.g., hydrolysis and oxidative pathways), potentially followed by conjugation in plants and animals. Its occurrence can vary by crop, environmental conditions, and processing. Accurate chemical identification and isotopic pattern confirmation are essential for unambiguous detection.
Analytical reference materials of defined purity and known concentration enable precise identification, calibration, and confirmation of this metabolite in complex matrices.
Uses and Applications in Analysis
Laboratories use CGA 226048 reference materials for calibration curves, matrix-matched quantification, retention-time and ion-ratio confirmation, recovery studies, and method validation (LOD/LOQ, linearity, precision, accuracy) in food, feed, water, and soil testing.
The material is also applied for proficiency testing preparation, internal QC checks, and stability studies in routine monitoring programs.
Regulatory Status and Residue Definitions
Regulatory frameworks for Metalaxyl/Metalaxyl-M often define residues as the parent or as the sum of parent and relevant metabolites, expressed as parent-equivalents, depending on commodity and jurisdiction. CGA 226048 may be considered in metabolism and risk assessments, data submission, and confirmatory analyses when specified by guidance.
Users should verify national and international residue definitions, MRLs, and enforcement policies to determine whether CGA 226048 must be monitored alongside the parent compound.
Monitoring and Analytical Methods
Primary determination is typically performed by LC–MS/MS due to the metabolite’s polarity and thermal behavior. High-resolution MS can support identity confirmation in complex matrices. Method development should ensure adequate chromatographic separation from isobars and matrix interferences.
Typical workflows include multi-residue methods with scheduled MRM transitions, isotopic dilution where available, and matrix-matched calibration to compensate ion suppression/enhancement.
Sample Preparation
QuEChERS-based extraction (citrate or acetate buffers) with appropriate clean-up (d-SPE, PSA/C18, or mixed-mode sorbents) is commonly employed. Method optimization should consider metabolite stability across pH, potential conversion from conjugates, and recoveries in high-water and high-acid matrices.
For water and soil, solid-phase extraction (SPE) and tailored elution protocols help concentrate analytes and reduce background interferences.
Typical Matrices
Fruits and vegetables, cereals, tea, spices, oilseeds, processed foods, drinking water, surface water, groundwater, and agricultural soils. Processing studies may be required to understand behavior during washing, cooking, and storage.
Health Impact – Human Toxicity
Risk assessment for metabolites considers toxicological relevance relative to the parent compound. Data requirements include comparative potency, exposure estimates, and aggregate dietary intake. Laboratories should follow applicable guidance when including CGA 226048 in risk-based surveillance or total diet studies.
Where regulatory evaluations identify toxicologically relevant metabolites, enforcement may include targeted monitoring or summation with the parent residue definition.
Environmental Impact and Fate
CGA 226048 can form in environmental compartments through abiotic and biotic degradation. Key processes include hydrolysis, microbial transformation, adsorption–desorption, and transport via runoff and leaching. Persistence and mobility depend on soil properties and climatic conditions.
Potential exposure to aquatic and terrestrial organisms is assessed through fate and ecotoxicology studies; inclusion of metabolites in monitoring programs supports a complete environmental risk profile.
Effects on Wildlife
Ecological evaluations consider acute and chronic endpoints in non-target organisms (aquatic species, pollinators, soil invertebrates). Where metabolites contribute materially to exposure, they may be included in monitoring designs to align with risk management objectives.
Safety and Handling
Handle reference materials in a fume hood using appropriate PPE (lab coat, gloves, eye protection). Avoid inhalation, ingestion, and skin contact. Follow SDS guidance and local regulations for use and disposal.
Dispose of waste solutions and consumables as hazardous chemical waste in accordance with institutional and legal requirements.
Stability, Storage, and Transport
Store sealed reference materials in amber glass at controlled temperature (typically 2–8 °C or as stated on the CoA/SDS). Minimize freeze–thaw cycles and light exposure. For solutions, use compatible solvents (e.g., acetonitrile or methanol) and observe labeled expiry dates.
Stability is supported by real-time or accelerated studies; users should monitor for changes in response factors and retention behavior in routine QC.
Quality and Traceability
HPC Standards provides CGA 226048 reference materials with gravimetric preparation, purity assessment, and full documentation. Certificates of Analysis include concentration, uncertainty, purity profile, solvent composition, and traceability to SI where applicable.
Batches are produced under stringent quality systems aligned with international requirements for reference materials used in regulated testing.
Analytical Standards and Calibration Support
Available as neat material (where feasible) and ready-to-use solutions at defined concentrations to streamline calibration and spiking. Custom concentrations, solvent systems, and multi-analyte mixes (including parent Metalaxyl/Metalaxyl-M) are available on request.
Isotope-labelled analogs and related metabolites can be provided to support isotopic dilution and identity confirmation.
Related Compounds
Metalaxyl (parent), Metalaxyl-M (enantiomerically enriched), and other known transformation products relevant to residue definitions. Including related components in calibration mixes can improve data quality and efficiency in targeted screens.
Industries and Use Cases
Accredited food and feed testing laboratories, contract research organizations, agrochemical manufacturers, environmental monitoring agencies, and water utilities using LC–MS/MS-based surveillance and regulatory compliance testing.
Documentation Package
Each reference material is supplied with a Certificate of Analysis, Safety Data Sheet, and product datasheet. Method support notes and uncertainty statements are provided to facilitate validation and accreditation requirements (e.g., ISO/IEC 17025).
Ordering Information
HPC Standards offers CGA 226048 reference materials in multiple pack sizes and concentrations with short lead times. Custom mixes and bulk volumes are available. Contact our technical team for matrix-specific recommendations, method-support, and regulatory alignment.