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Sulfatroxazole — Reference Materials for Residue Analysis
Sulfatroxazole Reference Materials PRECISION for Regulatory-Ready Residue Analysis
Ensure uncompromising accuracy with HPC Standards high-purity Sulfatroxazole reference materials. Manufactured and tested to international quality requirements, our neat materials and ready-to-use solutions deliver traceable calibration, robust QC, and confident compliance in food and environmental monitoring. Benefit from isotope-labelled options, custom multi-residue mixes, and expert technical support tailored to LCMSMS workflows. Trusted by ISOIEC 17025 laboratories worldwide for reliable quantification and defensible results.
Product | Catalog No./ CAS No. | Quantity | Price | |
|---|---|---|---|---|
ISO 17034 Reference Material |  | 693337 | 1X5MG | |
ISO 17034 Certified Reference Material D4-Sulfatroxazole solution |  | 693338 | 1X1ML | |
 | 681609 | 1X50MG | Please log in. |
High-quality reference materials for Sulfatroxazole to support accurate quantification in food and environmental monitoring, developed and tested to international quality requirements for confident regulatory compliance.
Overview
Sulfatroxazole is a sulfonamide antimicrobial compound used to treat bacterial infections. In residue analytics, it is monitored as part of the sulfonamide class due to its potential occurrence in animal-derived foods and environmental waters. Reliable determination requires validated methods and traceable reference materials to ensure data integrity across routine, confirmatory, and proficiency testing applications.
Uses
Historically applied in human and veterinary medicine, Sulfatroxazole belongs to the synthetic sulfonamides that inhibit bacterial folate synthesis. In residue control, laboratories frequently include Sulfatroxazole in multi-residue sulfonamide panels alongside structurally related compounds.
Chemical and Physical Properties
Typical sulfonamide characteristics include moderate polarity, aromatic amine/sulfonamide functional groups, and pH-dependent ionisation. These features influence extraction efficiency, chromatographic retention, and ionisation in LC–MS/MS. Method development often evaluates pH control, buffering, and matrix effects to ensure robust quantification.
Occurrence and Sources
Potential sources of Sulfatroxazole residues include therapeutic use in food-producing animals and discharge from healthcare or aquaculture applications. Environmental pathways comprise wastewater effluents, manure-amended soils, and surface waters. Residues may be detected in meat, liver, kidney, milk, eggs, honey, fish, surface water, groundwater, sediments, and wastewater.
Regulatory Landscape
Many jurisdictions regulate sulfonamide residues in food of animal origin within comprehensive veterinary drug frameworks. Compliance commonly requires monitoring single compounds and, in some cases, the sum of sulfonamides. Laboratories should consult the current regional legislation (e.g., EU, US, Codex) for matrix-specific limits, target analyte lists, and confirmatory criteria.
Monitoring and Target Matrices
Typical routine monitoring matrices include bovine/porcine/poultry muscle, liver, kidney, milk and dairy products, eggs, honey, fish and aquaculture products, animal feed, as well as environmental waters, soils, and sediments. Screening programs often apply multi-residue LC–MS/MS methods with confirmation via ion ratio criteria and retention time matching.
Sample Preparation
Established workflows use protein precipitation or buffered QuEChERS-type extraction, frequently with acidified solvents to improve recovery. Clean-up steps can include dispersive SPE (e.g., PSA/C18) or cartridge SPE to reduce matrix effects. For aqueous environmental samples, SPE (e.g., HLB-type sorbents) is commonly employed. Method validation should assess recovery, precision, matrix effects, and measurement uncertainty.
Analytical Methods
LC–MS/MS is the preferred technique for quantitative determination at low µg/kg (ppb) levels, employing multiple reaction monitoring, stable retention times, and compound-specific transitions. HPLC–UV/FLD methods may be suitable for higher concentration ranges or screening. Isotope dilution using labelled internal standards is recommended for improved accuracy and matrix compensation.
Quality Assurance and Traceability
Use of traceable reference materials with documented purity, identity, and uncertainty is essential for calibration, system suitability, and ongoing QC (e.g., QCs, spikes, blanks). Regular instrument performance checks, participation in proficiency tests, and adherence to ISO/IEC 17025 principles support defensible results and regulatory acceptance.
Health Impact — Human Toxicity
Sulfonamides can cause hypersensitivity reactions in susceptible individuals. Overexposure may lead to gastrointestinal, dermatological, or hematological effects depending on dose and duration. Food safety systems restrict residues to mitigate consumer exposure, particularly for sensitive populations.
Environmental Impact — Effects on Wildlife and Ecosystems
Antimicrobials released to the environment can affect microbial communities and select for antimicrobial resistance. Aquatic organisms may be exposed via effluents and run-off, warranting monitoring of surface waters, sediments, and biota to evaluate ecological risk.
Risk Management and Safety Measures
Laboratories should implement good laboratory practice, use appropriate PPE, and follow SDS instructions when handling Sulfatroxazole solutions or powders. Waste disposal must comply with local regulations for pharmaceutical and solvent waste. Robust chain-of-custody and documentation ensure sample integrity.
Storage and Stability
Store solid reference materials in a cool, dry, and light-protected environment. Store solutions refrigerated or frozen as specified on the certificate, avoiding repeated freeze–thaw cycles. Use amber containers and validated expiry/retest dates. Monitor stability with control charts where applicable.
Cross-Reactants and Metabolites
Analytical methods should consider structurally related sulfonamides and potential metabolites that may co-elute or share transitions. Chromatographic resolution, qualifier transitions, and accurate mass (where available) help minimise false positives.
Isotopically Labelled Derivatives
Stable isotope-labelled internal standards (e.g., 13C-, 2H-labelled Sulfatroxazole) improve accuracy by correcting for extraction efficiency and ion suppression/enhancement, supporting fit-for-purpose LOQs in complex food and environmental matrices.
Product Portfolio — Reference Materials for Sulfatroxazole
HPC Standards provides Sulfatroxazole reference materials as neat materials and ready-to-use solutions at various concentrations for calibration and quality control. Custom mixtures for multi-residue sulfonamide panels and matrix-matched solutions are available on request. All products are supplied with comprehensive documentation and are tested to international quality requirements.
Applications in Food and Environmental Analysis
Typical applications include official control, industry self-monitoring, method development/validation, proficiency testing support, and research on occurrence and fate. Matrices include meat, offal, milk, eggs, honey, fish, feed, surface water, wastewater, sediments, and soils.
Documentation and Compliance
Each reference material is delivered with a certificate detailing identity, purity or concentration, uncertainty (where applicable), storage conditions, and intended use. Documentation supports ISO/IEC 17025 and ISO 17034-based quality systems and regulatory audits.
Shipping and Availability
Products are shipped under controlled conditions with temperature protection where required. Global delivery options and lot reservation are available. For bulk quantities or custom concentrations, our team provides rapid quotation and lead times.
Technical Support
Our specialists assist with method selection, calibration strategies, uncertainty budgeting, and transition from screening to confirmatory workflows. Contact HPC Standards for tailored reference materials and technical guidance for Sulfatroxazole residue analysis.