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Robenidine hydrochloride – Reference Materials for Residue Analysis
Robenidine hydrochloride Precision Reference Materials for Confident Residue Compliance
Achieve reliable identification and quantification of robenidine residues with high-purity reference materials from HPC Standards. Our certified calibrants and ready-to-use solutions are manufactured under stringent quality systems to support LCMSMS method development, validation, and routine QC across poultry tissues, feed, and environmental matrices. Benefit from detailed CoAs, batch-to-batch consistency, and optional isotope-labelled derivatives for isotope dilution. Partner with our scientific team for tailored concentrations, matrix-matched solutions, and technical supportso your laboratory meets international MRL requirements with accuracy, traceability, and speed.
Product | Catalog No./ CAS No. | Quantity | Price | |
|---|---|---|---|---|
ISO 17034 Reference Material |  | 679695 | 1X10MG | Please log in. |
D8-Robenidine hydrochloride solution |  | 690773 | 1X1ML | Please log in. |
ISO 17034 Certified Reference Material D8-Robenidine hydrochloride solution |  | 694416 | 1X1ML | Please log in. |
ISO 17034 Reference Material |  | 676948 | 1X100MG | Please log in. |
Robenidine hydrochloride solution |  | 693491 | 1X5ML | Please log in. |
High-quality reference materials for robust identification and quantification of robenidine residues in food and environmental matrices. Manufactured under stringent quality systems to support regulatory compliance and method validation.
Overview
Robenidine hydrochloride is a veterinary anticoccidial (coccidiostat) used in poultry and other food-producing animals to prevent coccidiosis caused by Eimeria spp. It is typically administered via medicated feed. Due to its use in food-production systems, robenidine is subject to residue controls in edible tissues and derived products.
Use in Animal Production
Robenidine hydrochloride is applied as a feed additive in broiler chickens and, in some jurisdictions, in rabbits and turkeys. It is primarily used during the grow-out period to reduce morbidity and performance losses due to coccidial infections.
Use in laying hens is generally restricted or prohibited because robenidine can impart off-flavors (taint) to eggs. Withdrawal periods prior to slaughter are mandated to ensure residues are below regulatory limits.
Regulatory Status
Robenidine hydrochloride is regulated as a veterinary medicinal/feed additive. Many jurisdictions establish maximum residue limits (MRLs) in edible tissues (e.g., muscle, liver, skin/fat) and define mandatory withdrawal periods. Authorizations, conditions of use, and MRLs vary by region (e.g., EU, US, Codex, national authorities).
Typical regulatory frameworks specify marker residues (parent compound and/or specific metabolites) and target tissues for enforcement. Compliance requires validated analytical methods with demonstrated selectivity, sensitivity, and traceability to accredited reference materials.
Residue Monitoring
Common target matrices: poultry muscle, liver, skin/fat, kidney, and sometimes eggs (where applicable), as well as feed and feed premixes. Monitoring programs focus on verifying adherence to MRLs and correct application of withdrawal periods.
Sampling plans should account for production stage, feed changeover, and potential cross-contamination in mills. Environmental monitoring may include litter/manure and run-off where relevant.
Analytical Methods
Liquid chromatography coupled to tandem mass spectrometry (LC–MS/MS) is the preferred technique for regulatory monitoring due to selectivity and low limits of quantification. High-performance liquid chromatography with UV/fluorescence detection may be used for screening.
Typical workflows: QuEChERS-type or protein-precipitation extraction for tissues, followed by dispersive SPE or SPE cleanup; reversed-phase LC with ESI(+) MS/MS; multiple reaction monitoring of robenidine and relevant metabolites. Method performance characteristics include recovery, matrix effects, decision limit (CCα), detection capability (CCβ), and measurement uncertainty.
Metabolites and Marker Residues
Regulatory methods may quantify the parent compound and selected transformation products (e.g., N-dealkylated derivatives), expressed as robenidine equivalents in some jurisdictions. Selection of marker residues and conversion factors should follow the applicable regulation or guidance.
Method Validation and QA/QC
Validation should cover selectivity, linearity, accuracy, precision, LOQ, ruggedness, and stability across matrices. Routine QC includes matrix-matched calibration, fortified blanks, procedural blanks, and participation in proficiency tests where available.
Traceability relies on characterized reference materials with certified purity and documented uncertainty to ensure reliable quantitation and inter-laboratory comparability.
Stability and Storage Considerations
Robenidine hydrochloride may exhibit sensitivity to light and elevated temperatures. Store solid reference materials in tightly closed containers, protected from light, under cool and dry conditions. Prepare fresh working solutions as needed and verify solution stability (short- and long-term) under laboratory conditions.
Health Impact
Human toxicity: Robenidine is intended for veterinary use; direct human exposure should be avoided. Occupational contact with powders or solutions may cause irritation to skin, eyes, or respiratory tract. Implement appropriate engineering controls and PPE. Dietary exposure is regulated via MRLs designed to maintain consumer safety with established acceptable daily intakes (ADIs) where defined by authorities.
Environmental Impact
Excreted residues can enter litter/manure and potentially the environment through land application. Environmental risk assessments typically consider persistence, degradation (including photolysis), and aquatic and terrestrial toxicity. Good agricultural practices and manure management help mitigate exposure.
Effects on Wildlife
Non-target organisms may be exposed via contaminated litter/manure or run-off. Risk characterization depends on local use patterns and environmental conditions; adherence to authorized use and manure application guidelines reduces potential impacts.
Safety Measures (Industrial and Laboratory)
- Handle powders in controlled ventilation (fume hood) to minimize airborne exposure.
- Use gloves, lab coat, and eye protection; avoid skin contact and inhalation.
- Dispose of waste following institutional and regulatory requirements for veterinary pharmaceuticals.
- In feed mills and farms, prevent cross-contamination via dedicated lines, documented cleanout procedures, and verification testing.
Compliance and Documentation
Maintain complete documentation for chain-of-custody, method SOPs, validation reports, calibration records, and QC charts. For regulatory submissions and audits, ensure traceability of calibrants and reference materials, instrument maintenance logs, and personnel training records.
Applications for Industry
- Regulatory surveillance of poultry products to verify MRL compliance.
- Feed mill carryover investigations and cleanout verification.
- Method development and validation for multi-residue veterinary drug panels.
- Stability studies and storage condition assessments for fortified test materials.
HPC Standards Reference Materials
HPC Standards GmbH supplies characterized reference materials for robenidine hydrochloride to support quantitative residue analysis across food and environmental matrices. Options include neat materials and ready-to-use solutions upon request.
Benefits:
- High purity with detailed CoA, including identification, assay, and uncertainty data.
- Batch-to-batch consistency for calibration and method validation.
- Custom concentrations, solvent systems, and mixes to fit LC–MS/MS workflows.
Related Products and Derivatives
- Robenidine hydrochloride reference materials (neat and solution).
- Selected metabolites/marker residues where available.
- Stable isotope-labelled derivatives (on request) to improve quantitation via isotope dilution.
- Multi-analyte veterinary drug calibration mixes tailored for poultry matrices.
Technical Support
Our scientific team assists with method setup, matrix challenges, stability considerations, and selection of appropriate reference materials. We support laboratories in food and environmental analysis to meet international quality requirements and regulatory expectations.