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Thiouracil
Thiouracil High-Purity Reference Materials for Confident Residue Compliance
Ensure precise, defensible results with HPC Standards thiouracil reference materials engineered for LCMSMS calibration, validation, and routine QC. Our high-purity neat standards and ready-to-use solutionsoptionally with stable isotopelabelled analogssupport zero-tolerance enforcement in animal-derived foods, urine, feed, and environmental waters. Each lot is tested to international quality requirements and delivered with a comprehensive certificate purity, identity, concentration, uncertainty, storage, enabling robust matrix-matched calibration, isotope-dilution quantification, and reproducible confirmatory analysis. Rely on HPC Standards GmbH for consistent performance, regulatory alignment, and custom concentrations or mixtures tailored to your accredited workflows.
Product | Catalog No./ CAS No. | Quantity | Price | |
|---|---|---|---|---|
 | 692937 | 1X5MG | ||
ISO 17034 Certified Reference Material 13C,15N2-2-Thiouracil solution |  | 692938 | 1X1ML | Please log in. |
ISO 17034 Reference Material |  | 677039 | 1X250MG | Please log in. |
ISO 17034 Certified Reference Material 2-Thiouracil solution |  | 694524 | 1X5ML | Please log in. |
High-purity reference materials for thiouracil to support precise calibration, validation, and quality control in food and environmental residue analysis.
Overview
Thiouracil is a sulfur-containing uracil analog (a thioureide) best known for its antithyroid (thyreostatic) activity. It inhibits thyroid hormone synthesis by blocking thyroid peroxidase–mediated iodination. In residue analysis, thiouracil is monitored as a prohibited veterinary drug marker and a potential indicator of illicit growth promotion in food-producing animals.
Physicochemical traits relevant to analysis include high polarity, good water solubility, weak acidity (pKa in the acidic range), and UV absorbance. These features favor liquid chromatography with tandem mass spectrometry (LC–MS/MS) detection.
Uses
Historically used as an antithyroid pharmaceutical and, in some regions in the past, misused as a thyreostatic agent in livestock to enhance weight gain. Current legitimate veterinary use is banned or strictly controlled in many jurisdictions.
In analytical laboratories, thiouracil is a target residue/analyte for compliance monitoring in animal-derived foods, animal urine, feed, and environmental samples impacted by agricultural activities.
Regulatory Status
Thyreostatic substances, including thiouracil, are prohibited for use in food-producing animals in the EU and many other regions. Consequently, no MRLs are established; enforcement typically follows a zero-tolerance approach at the validated method’s decision limit (CCα) and detection capability (CCβ).
Compliance frameworks commonly referenced include EU legislation governing prohibited substances in animals and food, requirements for official control methods, and performance criteria for confirmatory analysis. Comparable prohibitions and enforcement policies exist in the UK, Canada, and other markets; in the United States, thiouracil is not permitted for livestock production.
Monitoring and Control
Sampling focuses on: (a) animal-derived foods (meat, offal, liver, kidney), (b) milk and eggs, (c) animal urine for screening/confirmatory testing, (d) feed and premixes, and (e) surface and wastewaters near farming operations.
Routine workflows employ risk-based sampling, rapid screening (e.g., LC–MS/MS multi-residue), and confirmatory targeted analysis with isotopically aided quantification. Proficiency testing and ongoing QC with certified reference materials support method robustness.
Health Impact
Human toxicity: Thiouracil is a potent thyroid peroxidase inhibitor. Exposure can depress thyroid hormone synthesis, potentially causing hypothyroidism, goiter, and related metabolic effects. Clinical signs may include fatigue, weight change, cold intolerance, and alterations in lipid and cardiovascular markers associated with thyroid dysfunction.
Occupational exposure may irritate eyes, skin, and respiratory tract. Sensitization is uncommon but possible. As with other antithyroid agents, prolonged or high exposure may exacerbate thyroid suppression; medical evaluation is advised if exposure is suspected.
Environmental Impact
Thiouracil is polar and may partition to aqueous phases. It can enter the environment via animal excreta and waste streams. Biotic and abiotic degradation are expected, but persistence depends on pH, microbial activity, and sunlight exposure.
Effects on wildlife: Potential thyroid-disrupting effects are of concern for fish and other aquatic organisms; sublethal endpoints (growth, development, behavior) are the primary risk focus. Actual risk is context-dependent and tied to local concentrations and attenuation processes.
Safety Measures
Handle thiouracil and its solutions in a chemical fume hood with appropriate PPE: lab coat, safety glasses, and suitable gloves. Avoid dust/aerosol formation and inhalation. Prevent skin and eye contact. Use dedicated tools to minimize cross-contamination of low-level residue laboratories.
Storage: keep tightly closed in inert, light-protective containers at controlled room temperature or refrigerated as specified on the certificate. Segregate from strong oxidizers. Dispose of waste according to local regulations.
Analytical Methods
Preferred technique: LC–MS/MS with electrospray ionization. Typical sample preparation for foods and urine includes protein precipitation and solid-phase extraction (SPE) or tailored QuEChERS-style cleanups adapted to polar analytes.
Key validation elements: specificity, matrix-matched calibration, ruggedness, recovery (usually 70–120% acceptance), precision across levels bracketing the decision limit, and verification of CCα/CCβ. Stable isotope–labelled internal standards are recommended for accurate quantification and matrix compensation.
Reference Materials from HPC Standards
HPC Standards GmbH provides high-purity thiouracil reference materials to support calibration, system suitability, method development, and quality control in residue analysis.
Product options include neat materials and ready-to-use solutions at defined concentrations. Stable isotope–labelled reference materials for thiouracil are available on request to enable isotope-dilution LC–MS/MS.
All reference materials are tested according to international quality requirements and meet the highest industrial standards. Each item is supplied with a detailed certificate including purity, identity confirmation, concentration (for solutions), uncertainty, and recommended storage conditions.
Applications in Food and Environmental Analysis
- Detection and confirmation of thiouracil in meat, offal, milk, and eggs to enforce prohibitions on thyreostatic agents.
- Screening and confirmatory analysis of animal urine in monitoring programs.
- Surveillance of feed and environmental waters near livestock facilities.
- Method validation, calibration curve preparation, QC spiking, recovery studies, and proficiency testing.
Documentation and Quality
Each shipment includes a product-specific certificate of analysis with traceable purity and concentration data, uncertainty estimates, storage and stability guidance, and safety information. Batch consistency and lot traceability support long-term method comparability.
Storage and Stability
Store in original, tightly sealed, light-protected containers. Follow temperature guidance on the certificate (commonly 2–8 °C for solutions). Allow solutions to equilibrate to room temperature before opening to prevent moisture ingress and concentration drift. Monitor unopened shelf life and in-use stability as stated on the certificate.
Compliance and Best Practices
Use matrix-matched calibration and isotopically labelled internal standards when possible. Include independent QC levels per batch, and review ion ratios, retention time tolerances, and calibration acceptance criteria aligned with applicable regulatory performance requirements for confirmatory analysis.
Ordering Information
Available pack sizes and concentrations are designed for common LC–MS/MS workflows. Custom concentrations, mixtures, and stable isotope–labelled reference materials can be provided upon request to fit laboratory methods and accreditation scopes.