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Methyl-quinoxaline-2-carboxylic acid (MQCA) – Reference Materials for Residue Analysis
Methyl-quinoxaline-2-carboxylic acid MQCA PREMIUM reference materials for confident LCMSMS residue analysis
Ensure traceable calibration and regulatory-compliant results with HPC Standards high-purity MQCA reference materials. Designed for accredited food and environmental laboratories, our MQCA solutions and neat standards support method development, validation, and routine QC with documented uncertainty, homogeneity, and full traceability. Available in ready-to-use concentrations or customized formats including isotope-labelled options and multi-analyte mixes, all products are produced to international quality requirements and delivered with comprehensive CoA and SDS. Rely on HPC Standards for consistent performance, rapid availability, and expert technical support.
Product | Catalog No./ CAS No. | Quantity | Price | |
|---|---|---|---|---|
 | 693065 | 1X5MG | ||
13C6-3-Methyl-quinoxaline-2-carboxylic acid solution |  | 693066 | 1X1ML | |
 | 681965 | 1X10MG | Please log in. |
High-quality reference materials for MQCA to support reliable LC–MS/MS residue monitoring in food and environmental matrices, developed and tested to international quality requirements.
Overview
Methyl-quinoxaline-2-carboxylic acid (commonly abbreviated MQCA) is a marker residue associated with certain quinoxaline-class veterinary medicinal products. It is monitored in food-producing animals and derived products to verify compliance with regulatory prohibitions or limits. MQCA is used as a target analyte in confirmatory methods and as a system-suitability marker in routine surveillance.
HPC Standards provides certified reference materials for MQCA to ensure traceable calibration, method validation, and ongoing quality control in accredited laboratories.
Chemical Identity & Synonyms
MQCA is structurally a quinoxaline bearing a carboxylic acid at position 2 and a methyl substituent on the heteroaromatic ring. It is frequently described in the literature as 3-methyl-2-quinoxalinecarboxylic acid (MQCA). Related marker residues include quinoxaline-2-carboxylic acid (QCA).
Synonyms used in residue control contexts: MQCA; methyl-2-quinoxalinecarboxylic acid; 3-methyl-quinoxaline-2-carboxylic acid.
Uses and Context
MQCA is analyzed as a marker residue to infer exposure to certain quinoxaline-class growth promoters/veterinary drugs historically used in food-producing animals. Surveillance programs test edible tissues, aquaculture products, and processed foods to confirm the absence of illegal administration and to enforce bans.
In laboratory workflows, MQCA serves as a target compound for method development, calibration, and proficiency testing.
Regulatory Landscape
Many jurisdictions (e.g., EU and others) prohibit the use of specific quinoxaline veterinary medicinal products in food-producing animals. As a result, competent authorities include MQCA (and related residues) in national residue monitoring plans. Action levels and performance criteria are defined in official control frameworks and guidance for confirmatory analysis.
Laboratories must employ validated confirmatory methods (typically LC–MS/MS) with adequate identification points, measurement uncertainty estimation, and trueness/precision verified through quality controls and reference materials.
Monitoring & Analytical Methods
Typical matrices: muscle, liver, kidney, fat, fish/shrimp, milk, eggs, feed, and environmental samples (e.g., water, sediment) where applicable.
Common techniques: LC–MS/MS with reversed-phase separation. Sample preparation often involves extraction with aqueous-organic solvents, cleanup via SPE or dispersive techniques, and conditions optimized to release bound residues where relevant.
Validation parameters: selectivity/specificity, linearity across relevant ranges, LOD/LOQ at or below regulatory targets, matrix effects assessment, recovery, repeatability/reproducibility, and measurement uncertainty. Use of stable isotope-labelled internal standards is recommended for best accuracy.
Health Impact
MQCA is a marker residue; risk assessments focus primarily on the parent veterinary substances from which MQCA derives. The presence of MQCA in edible tissues can indicate illegal or non-compliant treatment. Regulatory controls aim to protect consumers by preventing exposure to prohibited substances and their residues.
Environmental Impact
Quinoxaline residues may reach the environment via manure, aquaculture, or processing waste streams. Monitoring programs may include water and sediment when relevant to local risk assessments. Persistence and mobility depend on site-specific conditions; laboratories use reference materials to verify trace-level detection in complex environmental matrices.
Safety Measures
Handle MQCA reference materials in accordance with good laboratory practice. Avoid inhalation and contact with skin and eyes. Use appropriate PPE (lab coat, gloves, safety glasses) and work in well-ventilated areas or fume hoods. Consult the Safety Data Sheet (SDS) for hazard classifications and first-aid information.
Storage & Stability
Recommended storage: refrigerated or frozen as indicated on the certificate (commonly 2–8 °C for solutions; ≤ −18 °C for long-term storage). Protect from light and moisture. Allow solutions to reach room temperature before opening to avoid condensation. Track opening dates and adhere to assigned shelf life and use-before dates stated in the certificate.
Reference Materials from HPC Standards
HPC Standards manufactures and distributes high-purity MQCA reference materials for residue analysis in food and environmental testing. Products are produced under stringent quality management and are suitable for calibration, spike-recovery experiments, validation studies, and proficiency testing.
Available formats include neat solid and ready-to-use solution standards in common solvents (e.g., acetonitrile or methanol) at customer-specified concentrations.
Quality & Accreditation
Our MQCA reference materials are tested according to international quality requirements. Where applicable, characterization and value assignment are supported by validated methods with full traceability. Each batch is accompanied by a certificate providing assigned values, expanded uncertainty, and storage/use instructions. Options aligned with ISO 17034/ISO/IEC 17025 are available.
Product Specifications
Typical offering: neat MQCA with high chemical purity; solution reference materials at defined concentrations with verified composition, uncertainty, and homogeneity.
Customizations: concentration, solvent system, ampoule or vial size, multi-analyte mixtures (e.g., MQCA with QCA), and inclusion of stable isotope-labelled analogues on request.
Documentation
Each product includes a Certificate of Analysis (CoA) detailing identity confirmation (e.g., MS and chromatographic profile), purity assessment, assigned value and uncertainty, recommended storage, and shelf life. Safety Data Sheets (SDS) are provided for safe handling.
Applications
- Calibration and verification for LC–MS/MS quantification in animal-derived foods and aquaculture products
- Method validation (linearity, recovery, matrix effects, precision, LOQ) in regulatory surveillance
- Quality control samples for routine batch acceptance and long-term trend monitoring
- Proficiency testing and interlaboratory comparisons
Related Analytes
Commonly co-monitored residues include quinoxaline-2-carboxylic acid (QCA) and other marker residues associated with banned or restricted veterinary drugs. HPC Standards supplies a broad portfolio of reference materials for pesticides, veterinary drugs, their metabolites, and stable isotope-labelled derivatives.
Shipping & Availability
Products are shipped in temperature-appropriate packaging with light protection as required. Lead times are minimized through stocked inventory of common concentrations; custom formulations are available upon request.
Why HPC Standards
- Specialized portfolio for food and environmental residue analysis
- Consistent quality, robust documentation, and technical support
- Flexible customization, including isotope-labelled internal standards and multi-analyte mixes