Iomeprol – Reference Materials for Pharmaceutical and Environmental Analysis

Iomeprol reference materials Certified precision for LC-MSMS and HPLC

Ensure confident quantification with HPC Standards highpurity Iomeprol CRMs. Optimized for method validation, instrument calibration, and QAQC, our neat and solution standards support pharmaceutical QC and environmental monitoring of iodinated contrast media. Each lot comes with CoA and SDS, meeting international quality requirements and suitable for ISOIEC 17025 and ISO 17034 workflows. Request singleanalyte or tailormade multiICM mixes to match your matrix and LOQ targetsreliable performance, rapid delivery, and expert support for your lab.

Product		Catalog No./ CAS No.	Quantity	Price
ISO 17034 Certified Reference Material Iomeprol solution Concentration: 100 µg/ml Solvent: Water		682242 78649-41-9	1X5ML	Please log in.
ISO 17034 Reference Material Iomeprol		693622 78649-41-9	1X100MG	Please log in.

HPC Standards provides certified reference materials for Iomeprol to support robust LC‑MS/MS and HPLC method validation, instrument calibration, and quality control in pharmaceutical, clinical, and environmental laboratories.

Overview

Iomeprol (CAS 78649-41-9) is a non-ionic, low-osmolar, water‑soluble iodinated radiocontrast agent used for X‑ray and CT imaging. It is administered intravenously or intra‑arterially and is excreted largely unchanged via the kidneys. Its persistence and polarity make it a relevant pharmaceutical marker in wastewater and surface waters.

Chemical formula: C17H22I3N3O8; Molar mass: 777.09 g/mol. Common brand names include Imeron and Iomervu.

Uses

- Diagnostic radiology: intravascular contrast for X‑ray/CT procedures.

- Analytical reference in environmental monitoring programs targeting iodinated contrast media (ICMs) in wastewater effluent, surface water, and bank filtration studies.

Regulatory

- Pharmaceutical: Prescription‑only medicinal product; approved for medical use in several jurisdictions (e.g., US approval 2024). Specific national regulations apply to manufacturing, handling, and pharmacovigilance.

- Environment: ICMs are commonly addressed within “pharmaceuticals in the environment” frameworks; discharge permits and monitoring obligations may apply at wastewater treatment plants and hospitals according to local regulation.

Monitoring

- Matrix focus: hospital effluent, influent/effluent of WWTPs, surface waters, groundwater under bank filtration, and occasionally drinking water monitoring studies.

- Target analyte: parent Iomeprol (excreted unchanged). Include additional ICMs where relevant for comprehensive surveillance.

Health Impact

Human toxicity

- As a low‑osmolar, non‑ionic contrast agent, Iomeprol is generally better tolerated than high‑osmolar ionic agents. Adverse effects and contraindications are managed under clinical guidelines; renal function assessment and hydration protocols are standard risk‑mitigation measures.

Environmental Impact

- Fate: High polarity and low biodegradability; limited removal in conventional wastewater treatment; environmental persistence reported for the substance class.

Effects on wildlife

- Ecotoxicological profiles for ICMs indicate generally low acute toxicity; however, continuous input and persistence warrant monitoring to assess chronic exposure and mixture effects in aquatic ecosystems.

Safety Measures

- Laboratory handling: Use appropriate PPE, avoid aerosol formation, and implement spill containment. Follow institutional chemical hygiene plans.

- Storage: Store sealed, protected from light and moisture, according to the safety data sheet (SDS). Dispose of waste via authorized routes; avoid release to drains.

Analytical Methods

- Primary method: LC‑MS/MS with electrospray ionization; reversed‑phase or HILIC separations depending on method design.

- Typical performance goals: sub‑µg/L limits of quantification in water matrices with solid‑phase extraction (where applicable) or direct injection for high‑ionic-strength methods. Use isotope‑dilution when available to correct for matrix effects and recovery.

Analytical Standards

- HPC Standards supplies neat and solution reference materials for Iomeprol designed for calibration curves, system suitability, and QA/QC spikes.

- Options include single‑component solutions at defined concentrations and tailor‑made mixes with related iodinated contrast media upon request.

Quality and Compliance

- Manufactured and tested according to international quality requirements. Certificate of Analysis (CoA) includes identity confirmation, purity content, uncertainty, traceability, and recommended storage conditions.

- Batches are suitable for use in ISO/IEC 17025 and ISO 17034 compliant workflows.

Storage and Stability

- Recommended storage: cool, dry, and protected from light. For solution reference materials, observe the specified temperature range and shelf life on the CoA/label. Allow materials to equilibrate to room temperature before opening.

Method Development Notes

- Consider gradient elution to resolve Iomeprol from other ICMs and matrix interferences. Monitor multiple MRM transitions for confirmation. Validate recovery and matrix effects across relevant water matrices.

Documentation

- Each lot is delivered with CoA and SDS. Additional documentation (method support, custom concentrations, stability data) available on request.

Applications

- Pharmaceutical QC (identity and assay reference), environmental occurrence studies, wastewater treatment evaluation, and source‑tracking of hospital emissions.

Ordering Information

- Available as neat material or pre‑diluted solutions in common solvents and concentration ranges for LC‑MS/MS. Custom packaging, concentrations, and multi‑analyte mixes available upon request to support your specific method and matrix.