Iomeprol – Reference Materials for Pharmaceutical and Environmental Analysis
Iomeprol reference materials – Certified precision for LC-MS/MS and HPLC
Ensure confident quantification with HPC Standards’ high‑purity Iomeprol CRMs. Optimized for method validation, instrument calibration, and QA/QC, our neat and solution standards support pharmaceutical QC and environmental monitoring of iodinated contrast media. Each lot comes with CoA and SDS, meeting international quality requirements and suitable for ISO/IEC 17025 and ISO 17034 workflows. Request single‑analyte or tailor‑made multi‑ICM mixes to match your matrix and LOQ targets—reliable performance, rapid delivery, and expert support for your lab.
Product | Catalog No./ CAS No. | Quantity | Price | |
|---|---|---|---|---|
ISO 17034 Certified Reference Material Iomeprol solution |  | 682242 | 1X5ML | Please log in. |
ISO 17034 Reference Material |  | 693622 | 1X100MG | Please log in. |
HPC Standards provides certified reference materials for Iomeprol to support robust LC‑MS/MS and HPLC method validation, instrument calibration, and quality control in pharmaceutical, clinical, and environmental laboratories.
Overview
Iomeprol (CAS 78649-41-9) is a non-ionic, low-osmolar, water‑soluble iodinated radiocontrast agent used for X‑ray and CT imaging. It is administered intravenously or intra‑arterially and is excreted largely unchanged via the kidneys. Its persistence and polarity make it a relevant pharmaceutical marker in wastewater and surface waters.
Chemical formula: C17H22I3N3O8; Molar mass: 777.09 g/mol. Common brand names include Imeron and Iomervu.
Uses
- Diagnostic radiology: intravascular contrast for X‑ray/CT procedures.
- Analytical reference in environmental monitoring programs targeting iodinated contrast media (ICMs) in wastewater effluent, surface water, and bank filtration studies.
Regulatory
- Pharmaceutical: Prescription‑only medicinal product; approved for medical use in several jurisdictions (e.g., US approval 2024). Specific national regulations apply to manufacturing, handling, and pharmacovigilance.
- Environment: ICMs are commonly addressed within “pharmaceuticals in the environment” frameworks; discharge permits and monitoring obligations may apply at wastewater treatment plants and hospitals according to local regulation.
Monitoring
- Matrix focus: hospital effluent, influent/effluent of WWTPs, surface waters, groundwater under bank filtration, and occasionally drinking water monitoring studies.
- Target analyte: parent Iomeprol (excreted unchanged). Include additional ICMs where relevant for comprehensive surveillance.
Health Impact
Human toxicity
- As a low‑osmolar, non‑ionic contrast agent, Iomeprol is generally better tolerated than high‑osmolar ionic agents. Adverse effects and contraindications are managed under clinical guidelines; renal function assessment and hydration protocols are standard risk‑mitigation measures.
Environmental Impact
- Fate: High polarity and low biodegradability; limited removal in conventional wastewater treatment; environmental persistence reported for the substance class.
Effects on wildlife
- Ecotoxicological profiles for ICMs indicate generally low acute toxicity; however, continuous input and persistence warrant monitoring to assess chronic exposure and mixture effects in aquatic ecosystems.
Safety Measures
- Laboratory handling: Use appropriate PPE, avoid aerosol formation, and implement spill containment. Follow institutional chemical hygiene plans.
- Storage: Store sealed, protected from light and moisture, according to the safety data sheet (SDS). Dispose of waste via authorized routes; avoid release to drains.
Analytical Methods
- Primary method: LC‑MS/MS with electrospray ionization; reversed‑phase or HILIC separations depending on method design.
- Typical performance goals: sub‑µg/L limits of quantification in water matrices with solid‑phase extraction (where applicable) or direct injection for high‑ionic-strength methods. Use isotope‑dilution when available to correct for matrix effects and recovery.
Analytical Standards
- HPC Standards supplies neat and solution reference materials for Iomeprol designed for calibration curves, system suitability, and QA/QC spikes.
- Options include single‑component solutions at defined concentrations and tailor‑made mixes with related iodinated contrast media upon request.
Quality and Compliance
- Manufactured and tested according to international quality requirements. Certificate of Analysis (CoA) includes identity confirmation, purity content, uncertainty, traceability, and recommended storage conditions.
- Batches are suitable for use in ISO/IEC 17025 and ISO 17034 compliant workflows.
Storage and Stability
- Recommended storage: cool, dry, and protected from light. For solution reference materials, observe the specified temperature range and shelf life on the CoA/label. Allow materials to equilibrate to room temperature before opening.
Method Development Notes
- Consider gradient elution to resolve Iomeprol from other ICMs and matrix interferences. Monitor multiple MRM transitions for confirmation. Validate recovery and matrix effects across relevant water matrices.
Documentation
- Each lot is delivered with CoA and SDS. Additional documentation (method support, custom concentrations, stability data) available on request.
Applications
- Pharmaceutical QC (identity and assay reference), environmental occurrence studies, wastewater treatment evaluation, and source‑tracking of hospital emissions.
Ordering Information
- Available as neat material or pre‑diluted solutions in common solvents and concentration ranges for LC‑MS/MS. Custom packaging, concentrations, and multi‑analyte mixes available upon request to support your specific method and matrix.