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Tinidazole – Reference Materials for Residue and Environmental Analysis
Tinidazole Precision Reference Materials for Confident Residue Analysis
Accelerate compliant LC-MSMS workflows with Tinidazole reference materials from HPC Standards. Rely on certified documentation, tight batch-to-batch consistency, and isotopically labelled options to strengthen method development, validation, and routine quantification across food, veterinary, and environmental matrices. Our high-purity standards support ISOIEC 17025 and ISO 17034-based workflows, helping your lab meet stringent EUUS regulatory targets with matrix-matched accuracy. Available as neat solids, ready-to-use solutions, and custom calibration setsdelivered with CoA, SDS, and temperature-controlled logistics. Partner with HPC Standards for reliable results and seamless audits.
Product | Catalog No./ CAS No. | Quantity | Price | |
|---|---|---|---|---|
 | 691977 | 1X10MG | Please log in. | |
D5-Tinidazole solution |  | 691978 | 1X1ML | Please log in. |
 | 679180 | 1X10MG | Please log in. | |
ISO 17034 Certified Reference Material |  | 693270 | 1X10MG | Please log in. |
High-quality tinidazole reference materials for robust method development, validation, and routine quantification in food, veterinary, and environmental matrices. Certified documentation, batch consistency, and isotopically labelled options available.
Overview
Tinidazole (CAS 19387-91-8) is a 5-nitroimidazole antimicrobial used against protozoa and anaerobic bacteria. It is applied in human and veterinary medicine and is monitored in food-of-animal-origin and environmental matrices due to potential residues and ecological exposure.
Chemical identifiers: IUPAC: 1-(2-ethylsulfonylethyl)-2-methyl-5-nitro-imidazole; Molecular formula: C8H13N3O4S; Molar mass: 247.27 g/mol; SMILES: CCS(=O)(=O)CCN1C(=NC=C1[N+](=O)[O-])C; InChI Key: HJLSLZFTEKNLFI-UHFFFAOYSA-N.
Uses
Therapeutic uses include treatment of protozoan infections such as Giardia, Trichomonas vaginalis, and amoebic dysentery, and as an alternative in metronidazole intolerance. Veterinary classifications exist (e.g., ATCvet QP51AA02), indicating potential use in animals in certain jurisdictions.
Industrial relevance for laboratories: surveillance of residues in food-producing animals, wastewater-based epidemiology, and surface water monitoring.
Regulatory Landscape
Regulation varies by region. Tinidazole is prescription-only in many countries for therapeutic use. In residue control, nitroimidazoles may be restricted or prohibited in food-producing animals in several jurisdictions, with stringent limits (often “zero tolerance” policies or very low screening targets). Always consult current EU, US, Codex, and national regulations for MRLs, RLs, or prohibited substance lists applicable to your matrix and market.
For method validation in regulated analysis, apply guidelines such as EU 2021/808 (replacing 2002/657/EC) for veterinary drug residues or EPA/ISO methods for environmental monitoring.
Monitoring and Typical Matrices
Food and feed: muscle, liver, kidney, milk, eggs, honey. Targets include parent tinidazole; consider inclusion of related nitroimidazoles in multi-residue methods.
Environmental: influent/effluent wastewater, surface waters, sediments, sludge. Monitoring supports assessment of pharmaceutical loads and mitigation performance of WWTPs.
Analytical Methods
- LC-MS/MS is the method of choice for sensitivity and selectivity in complex matrices. Typical sample preparation includes SPE for water and dairy, LLE or SPE for tissue, and QuEChERS-based workflows for multi-residue screens.
- HPLC-UV or DAD can be used for higher concentration levels or screening but may require enhanced cleanup.
- Include isotopically labelled internal standards where available to correct for matrix effects and recovery variability. Validate linearity, recovery, matrix effects, LOD/LOQ, precision, trueness, and measurement uncertainty per applicable guidance.
Method Performance Targets
Screening detection limits should meet or exceed regulatory requirements (e.g., sub-µg/kg levels for food; ng/L–low µg/L for environmental water). Employ matrix-matched calibration and recovery-corrected quantification for compliance-grade data.
Health Impact
Human toxicity: Tinidazole is generally well tolerated clinically but may cause adverse effects. Co-ingestion of alcohol can trigger a disulfiram-like reaction (nausea, vomiting, flushing, headache). Pharmacokinetics: hepatic metabolism (CYP3A4), protein binding ~12%, plasma half-life ~12–14 h, excretion via urine and feces.
Occupational exposure in laboratories is typically minimal at reference-material quantities; handle as potentially hazardous. Avoid ingestion, inhalation, and skin contact.
Environmental Impact
Tinidazole and related nitroimidazoles can persist through wastewater treatment and be detected in aquatic environments. Ecotoxicity data are limited; prudent monitoring is recommended to assess potential risks to aquatic organisms and to track antimicrobial loadings.
Effects on Wildlife
Data on chronic effects are limited. As with other antimicrobials, unintended exposure may impact microbial communities and, indirectly, aquatic food webs. Site-specific risk assessments should be informed by measured concentrations and toxicity benchmarks where available.
Safety Measures (Laboratory Handling)
- Use appropriate PPE (lab coat, gloves, safety glasses). Work in a well-ventilated area or fume hood when handling powders or preparing solutions.
- Storage: keep tightly closed, dry, and protected from light at recommended temperatures. Prepare working solutions with high-purity solvents; record preparation and expiry dates.
- Dispose of solutions and extracts according to local hazardous waste regulations.
Quality and Compliance
HPC Standards reference materials are produced under stringent quality controls, accompanied by Certificates of Analysis detailing identity, purity, concentration (for solutions), uncertainty, traceability, and stability information to support ISO/IEC 17025 and ISO 17034-based workflows.
Analytical Standards (Reference Materials)
- Available formats: neat solids and ready-to-use solutions at defined concentrations.
- Isotopically labelled analogues: offered where applicable for internal standardization in LC-MS/MS.
- Custom mixtures and calibration sets: matrix-appropriate ranges for food and environmental applications.
- Documentation: CoA, Safety Data Sheet, and shipping with temperature control where required.
Applications
- Regulatory residue testing in animal-derived foods and honey.
- Environmental surveillance: WWTP influent/effluent, rivers, and sediments.
- Method development and validation for multi-class antimicrobial panels.
Ordering Information
Contact HPC Standards for product codes, packaging sizes, concentration ranges, and lead times. Bulk and custom solution preparation are available upon request.
Synonyms and Identifiers
Names: Tinidazole; Trade names include Tindamax (regional). Class: Nitroimidazole antimicrobial.
CAS: 19387-91-8; PubChem CID: 5479; DrugBank: DB00911; UNII: 033KF7V46H.
Disclaimer
Regulatory limits and legal status vary by country and matrix. Users are responsible for ensuring methods and limits comply with current regional regulations and accreditation requirements.