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Imidocarb dihydrochloride — Reference Materials for Residue Analysis
Imidocarb dihydrochloride Precision Reference Materials for Confident Residue Compliance
Drive LC-MSMS accuracy with high-purity, traceable imidocarb dihydrochloride standards from HPC Standards GmbH. Engineered for food and environmental matrices, our validated materials deliver consistent calibration, robust QC, and audit-ready documentation. Choose neat or ready-to-use solutions, with CoA-backed purity, uncertainty, and storage guidanceplus isotopically labeled options on request. Ensure reliable MRL verification, streamlined method development, and repeatable performance that meets international quality requirements.
Product | Catalog No./ CAS No. | Quantity | Price | |
|---|---|---|---|---|
 | 679678 | 1X10MG | Please log in. | |
D8-Imidocarb dihydrochloride solution |  | 690913 | 1X1ML | |
 | 693039 | 1X10MG | Please log in. | |
Imidocarb dihydrochloride solution |  | 693040 | 1X1ML |
High-quality reference materials for precise quantification of imidocarb dihydrochloride in food and environmental matrices, manufactured and tested to international quality requirements.
Overview
Imidocarb dihydrochloride is a veterinary antiprotozoal compound used primarily for the treatment and control of babesiosis and anaplasmosis in animals. Laboratories monitor residues of imidocarb and its salts in edible tissues and related matrices to ensure compliance with regulatory maximum residue limits (MRLs).
HPC Standards provides validated reference materials for accurate identification and quantification of imidocarb dihydrochloride by LC-MS/MS and related techniques.
Chemical Identity
Substance: Imidocarb dihydrochloride (salt of imidocarb)
Approximate molecular formula (base): C19H20N6O; dihydrochloride adds 2 HCl equivalents
Approximate molecular weight: ~421.3 g/mol (dihydrochloride)
Physicochemical properties: polar, salt form enhances aqueous solubility; thermally labile; LC-MS/MS amenable.
Uses
Veterinary medicine: treatment and prophylaxis of protozoal infections (e.g., Babesia spp.).
Residue control: monitoring in meat, liver, kidney, and occasionally milk or blood to verify adherence to withdrawal periods.
Mode of Action
Antiprotozoal activity associated with interference in nucleic acid and polyamine pathways in target parasites, leading to impaired replication and survival.
Regulatory Status
Subject to veterinary drug MRLs in food-producing animals; limits vary by jurisdiction (e.g., EU, Codex, national authorities). Typical target matrices include muscle, liver, kidney, and fat.
Compliance requires validated analytical methods and traceable reference materials for calibration and quality control.
Monitoring and Residue Analysis
Typical matrices: muscle, liver, kidney, fat, milk, and sometimes animal feed or environmental samples near treated livestock.
Common methods: LC-MS/MS with electrospray ionization; sample preparation via protein precipitation and/or SPE cleanup; matrix-matched calibration and use of internal standards recommended.
Reporting: results compared against jurisdiction-specific MRLs; uncertainty estimation and quality control charts advised.
Health Impact (Human Toxicity)
Imidocarb is not intended for human therapeutic use. Potential adverse effects include cholinergic-like symptoms, hepatotoxicity, and nephrotoxicity at elevated exposures. Laboratory handling requires stringent controls to minimize exposure.
Risk management in the food chain relies on adherence to withdrawal periods and MRL-compliant residue levels.
Environmental Impact
Excreted residues may enter manure and surface waters. Potential risks include toxicity to aquatic organisms and alterations of microbial communities. Good veterinary practices and waste management reduce environmental loading.
Effects on Wildlife
Non-target exposure in wildlife is considered low when veterinary use complies with label directions, but aquatic and scavenger exposure should be minimized through responsible disposal and pasture management.
Safety Measures and Handling
Laboratory PPE: lab coat, nitrile gloves, safety glasses; handle powders in a fume hood.
Avoid inhalation and skin contact; prevent cross-contamination using dedicated tools and containers.
Spill response: contain, avoid dust generation, clean with damp disposable wipes, and dispose according to institutional rules.
Stability and Storage
Store reference materials tightly closed, protected from light, at 2–8 °C (or as specified on the CoA). Avoid repeated freeze–thaw for solutions.
Assess stability with control charts; follow expiration dates and requalification guidance on documentation.
Analytical Methods
Chromatography: reverse-phase LC with acidic mobile phases; monitor specific MRM transitions for imidocarb.
Preparation: tissue homogenization, protein precipitation (e.g., acetonitrile), centrifugation, and SPE cleanup when needed to reduce matrix effects.
Quality controls: blanks, spikes, matrix-matched calibrators, and recovery checks; use internal standards where available.
Analytical Standards
Use traceable reference materials for calibration curves, system suitability, and ongoing QC. Include certified purity, concentration (for solutions), and uncertainty on documentation.
Matrix-matched calibration and isotopically labeled internal standards are recommended to correct for recovery and ion suppression.
HPC Standards Reference Materials
HPC Standards GmbH supplies high-purity reference materials for imidocarb dihydrochloride to support reliable residue analysis in food and environmental matrices.
Key features: certificate of analysis with traceability, purity assessment, uncertainty, recommended storage, and intended use; batch-to-batch consistency aligned with international quality requirements.
Available formats: neat material and ready-to-use solutions at defined concentrations; custom concentrations on request. Isotope-labeled derivatives and metabolites available on inquiry.
Applications
Regulatory monitoring in official control laboratories and contract testing labs.
Method development/validation (LOD/LOQ establishment, recovery studies, matrix effect evaluation).
Routine QC: calibration verification, system suitability, and proficiency testing.
Compliance and Quality Assurance
Our reference materials support compliance with international guidelines for veterinary drug residue analysis and underpin robust QA systems in accredited laboratories.
Documentation supplied supports auditability and method traceability from sample intake to result reporting.
Packaging and Documentation
Secure, tamper-evident packaging with clear labeling of lot number, concentration (for solutions), storage, and expiry.
Each delivery includes a comprehensive certificate of analysis and safety data sheet to facilitate immediate use in validated methods.