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Lysine — Reference Materials for Analytical Quality Control
Lysine Precision Reference Materials for Confident Quantification
Ensure accurate, traceable lysine measurement with certified reference materials from HPC Standards GmbH. Our high-purity neat and solution standardsplus matched stable isotope-labelled lysineenable robust calibration, spike-recovery, and method validation across LCMSMS, HILICRP-LC, ion-exchange, and CE workflows. Delivered with CoA and SDS, produced under ISO 1703417025-aligned quality systems, and optimized for food, feed, pharma, clinical, and bioprocess applications, HPC standards support regulatory compliance, batch-to-batch consistency, and reliable routine QC. Custom concentrations, multi-analyte mixes, and recurring supply programs available.
Product | Catalog No./ CAS No. | Quantity | Price | |
|---|---|---|---|---|
ISO 17034 Reference Material |  | 691097 | 1X100MG | |
ISO 17034 Reference Material |  | 690774 | 1X100MG | Please log in. |
ISO 17034 Certified Reference Material L-Lysine solution |  | 693293 | 1X5ML | Please log in. |
HPC Standards GmbH supplies certified reference materials for Lysine to support accurate quantification and method validation across food, feed, pharmaceutical, and environmental testing laboratories.
Overview
Lysine (L-lysine) is an essential α-amino acid used in protein biosynthesis. It is basic and positively charged at physiological pH and occurs naturally in foods and biological matrices. In analytics, lysine serves as a target/analyte, system suitability marker, and process control in amino acid profiling and metabolomics.
HPC reference materials for lysine enable traceable calibration, spike-recovery studies, method validation, and routine QC in LC-based workflows.
Chemical Identity
Primary name: L-Lysine; IUPAC: 2,6-diaminohexanoic acid
CAS: 56-87-1 (L), 70-54-2 (DL), 923-27-3 (D)
Molecular formula: C6H14N2O2; Molar mass: 146.19 g/mol; High water solubility (~1.5 kg/L)
Synonyms: L-Lys, LYS, h-Lys-OH
Applications in Analysis
- Quantitation of free and total amino acids in foods (protein quality, fortification control)
- Feed additive verification (label claim compliance for lysine supplementation)
- Clinical and metabolomics panels (nutritional status, inborn errors of metabolism)
- Bioprocess monitoring (fermentation media tracking, yield optimization)
- Pharmaceutical QC (excipients, parenteral nutrition solutions)
Sample Matrices
Food and beverages (grains, legumes, dairy, meat), feed and premixes, dietary supplements, plasma/serum/urine, fermentation broths, pharmaceuticals, and environmental/industrial process waters.
Monitoring and Methods
- LC–MS/MS (MRM) of underivatized or derivatized lysine for high selectivity
- HILIC or RP-LC with pre-column derivatization (e.g., OPA/FMOC, AQC) and fluorescence/UV
- Ion-exchange chromatography with post-column ninhydrin detection
- CE with UV/MS for high-throughput amino acid profiling
Typical challenges: retention of very polar cations, matrix suppression, derivatization reproducibility. Reference materials from HPC support calibration curve linearity, system suitability, and recovery studies.
Regulatory Status
Food/feed: L-lysine is authorized globally as a nutritional amino acid and feed additive; compliance requires verification of content and purity in fortified products and premixes.
Pharmaceuticals: Used in parenteral nutrition and formulations; testing follows pharmacopoeial or validated LC methods and ICH Q2(R2) validation principles.
Clinical labs: Quantification in human specimens under ISO 15189/CLIA frameworks using validated methods and traceable calibrators.
Analytical Standards
HPC provides neat and solution-based reference materials for lysine and related analytes with traceable purity assignment. Matched internal standards (e.g., stable isotope-labelled lysine) are available to correct matrix effects and enhance quantitative accuracy.
Specifications of HPC Reference Materials
- Identity confirmed by LC–MS and NMR where applicable
- Purity typically ≥98% (neat); solution concentrations gravimetrically prepared
- Uncertainty budgets established according to ISO 17034/ISO/IEC 17025 principles
- Accompanying documentation: Certificate of Analysis (CoA), Safety Data Sheet (SDS)
Packaging and Stability
- Neat material: amber glass vials with inert closures
- Ready-to-use solutions: aqueous or aqueous-organic matrices suitable for LC workflows
- Stability monitored through real-time/accelerated studies; expiry and storage conditions stated on CoA
Documentation and Quality
Produced under stringent quality systems aligned with international requirements to ensure traceability, measurement uncertainty, and batch-to-batch consistency for regulatory audits and method validation.
Safety and Handling
Lysine exhibits low acute toxicity and is widely used nutritionally; handle laboratory-grade materials using standard PPE (lab coat, gloves, eye protection). Avoid contamination and moisture uptake. Consult SDS for detailed hazard and first-aid information.
Storage Conditions
Store sealed vials as indicated on the CoA/SDS. Typical recommendations: 2–8°C for aqueous solutions; desiccated and protected from light for neat material. Allow to equilibrate to room temperature before opening to prevent condensation.
Health Impact
Lysine is essential in humans; deficiency impacts protein status, connective tissue integrity, and carnitine-related fatty acid metabolism. Clinical quantification supports diagnosis of metabolic disorders (e.g., hyperlysinemia) and nutritional assessment.
Environmental Impact
Lysine is a naturally occurring, readily biodegradable amino acid with low environmental hazard. Routine environmental monitoring is generally not required except in specialized industrial process contexts.
Related Compounds and Isotopologues
- D- and DL-lysine (for chiral method development)
- Stable isotope-labelled lysine (e.g., 13C/15N-labelled) for use as internal standards in LC–MS/MS
- Derivatives for specific workflows (e.g., lysine hydrochloride for supplements)
Custom Services
HPC offers custom concentrations, solvent systems, multi-analyte mixes (amino acid panels), and bulk packs. Lot reservation and recurring supply programs are available for GMP and high-throughput labs.
Frequently Used Concentrations and Solvents
Common solution levels: 100–1000 µg/mL in water or water/acetonitrile with 0.1% formic acid for LC–MS; alternative buffers for fluorescence/UV derivatization workflows available on request.
QC and Calibration Guidance
Use primary reference materials to establish calibration curves across expected matrix ranges; apply isotope-dilution where possible. Verify linearity, LOD/LOQ, precision, trueness, and recovery per ISO/IEC 17025 and ICH Q2(R2). Include independent QC levels to monitor drift.
Industries Served
Food and feed manufacturers, contract testing laboratories, clinical and metabolomics labs, pharmaceutical producers, and bioprocess/fermentation facilities.