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Diaminodiphenyl sulfide (Thiodianiline) — Reference Materials for Advanced Residue and Environmental Analysis
Diaminodiphenyl sulfide High-Purity Reference Materials for Confident Trace Analysis
Accelerate your environmental and industrial hygiene testing with Diaminodiphenyl sulfide Thiodianiline reference materials from HPC Standards. Our high-purity neat substances and ready-to-use solutions are manufactured under rigorous QC, supplied with full CoAs, and tested to international quality requirements. Achieve reliable quantification across complex matriceswater, sediments, polymer extracts, workplace airwith matrix-matched calibration support, optional isotopelabelled internal standards, and proven LC-MSMS compatibility. Custom concentrations, solvent systems, and multi-analyte mixes are available to fit your method. Ensure compliance, improve reproducibility, and safeguard decisions with standards engineered for accuracy and stability.
Product | Catalog No./ CAS No. | Quantity | Price | |
|---|---|---|---|---|
ISO 17034 Reference Material |  | 676773 | 1X250MG | Please log in. |
4,4'-Diaminodiphenyl sulfide solution |  | 679879 | 1X1ML | Please log in. |
ISO 17034 Certified Reference Material |  | 694267 | 1X100MG | Please log in. |
HPC Standards GmbH provides high-purity reference materials for Diaminodiphenyl sulfide to support accurate, reproducible quantification in environmental, industrial hygiene, and materials-related residue analysis. Our products are tested according to international quality requirements and meet the highest industrial standards.
Overview
Diaminodiphenyl sulfide (4,4'-diaminodiphenyl sulfide), commonly known as thiodianiline (TDA), is an aromatic amine consisting of two aniline rings linked by a thioether (sulfide) bridge. It is a solid organic compound used primarily as an intermediate in dye and polymer chemistry and may appear as an impurity or transformation product in industrial and environmental contexts.
In residue and environmental monitoring, Diaminodiphenyl sulfide is relevant as a potential contaminant in water, sediments, leachates from colored materials, and industrial effluents, and as a workplace exposure analyte in rubber, pigment, and dye manufacturing.
Synonyms and Identifiers
Common names: Thiodianiline; 4,4'-Diaminodiphenyl sulfide; p,p'-Diaminodiphenyl sulfide.
CAS: 139-65-1; Molecular formula: C12H12N2S; Approx. molecular weight: 216.30 g/mol.
Structure: two para-aminophenyl groups linked via –S–. Low water solubility; soluble in common organic solvents (e.g., DMSO, methanol, acetone); high thermal stability with melting in the high °C range; prone to oxidative discoloration upon air/light exposure.
Uses and Sources
- Intermediate in the synthesis of sulfur-containing azo dyes and specialty pigments.
- Additive or intermediate in rubber and polymer processing (antioxidant and vulcanization-related chemistries).
- Potential impurity or degradation/transformation product in colored consumer materials and industrial residues.
Regulatory Status
- Managed under general chemicals regulations (e.g., REACH in the EU) with hazard communication via Safety Data Sheets and classification/labeling as applicable.
- Workplace exposure may be subject to national occupational exposure limits and risk management requirements.
- Discharge to water is regulated under environmental permitting; waste streams containing aromatic amines are typically handled as hazardous waste.
Monitoring and Target Matrices
- Environmental: surface water, groundwater, wastewater, industrial effluents, sediments, sludge.
- Materials-related: polymer extracts, dyes/pigments, leachates and migration studies (simulants) from colored articles.
- Occupational hygiene: workplace air (sorbent tube sampling), wipe samples, process residues.
Analytical Methods
- LC-UV/FLD: Direct determination or after derivatization for sensitivity/selectivity improvements.
- LC-MS/MS: Preferred for trace analysis in complex matrices; achieves low ng/L–µg/L levels in waters and sub-µg/kg in solids with appropriate cleanup.
- GC-MS: Possible after derivatization (e.g., acylation/silylation) to improve volatility and stability.
- Confirmatory analysis: Use of qualifier ions/ion ratios, retention time matching, and matrix-matched calibration to ensure specificity.
Sample Preparation
- Aqueous samples: Solid-phase extraction (SPE), often mixed-mode cation-exchange or polymeric sorbents; pH control to favor amine retention.
- Solids/sediments: Accelerated solvent extraction or ultrasonic extraction with polar organic solvents; cleanup via SPE (normal phase or ion-exchange).
- Materials: Soxhlet or solvent migration tests under standardized conditions; dilution and filtration prior to LC/GC analysis.
Calibration and Quantification
- Use matrix-matched calibration or standard addition to minimize matrix effects.
- Incorporate internal standards (ideally stable isotope-labelled analogs where available) to correct for recovery and ionization variability.
- Validate linearity, LOQ, recovery, repeatability, and measurement uncertainty according to laboratory SOPs and applicable guidelines.
Method Performance
- Typical LOQs: low ng/L in clean waters (LC-MS/MS), higher for complex matrices depending on cleanup.
- Recoveries: commonly 70–110% with optimized SPE and pH control; monitor for breakthrough and derivatization efficiency (if used).
- Stability: Monitor potential oxidation to sulfoxide/sulfone species and N-acetylation during sample storage; store extracts cold and protected from light.
Health Impact — Human Toxicity
- Aromatic diamine with potential for acute and chronic toxicity; may cause skin/eye irritation and sensitization.
- Possible mutagenicity/genotoxicity concerns similar to related aromatic amines; adopt precautionary handling and exposure minimization.
- Exposure routes: dermal, inhalation of dust/aerosols, and accidental ingestion; implement controls and biological/air monitoring where relevant.
Environmental Impact — Fate and Effects on Wildlife
- Persistence: Reduced biodegradability relative to simple amines due to aromaticity; may adsorb to sediments and organic matter.
- Transformation: Oxidation to sulfoxide/sulfone; conjugation and deamination can occur in biotic systems.
- Ecotoxicity: Aromatic amines can be toxic to aquatic organisms; effect levels are matrix- and species-dependent; minimize releases to the environment.
Safety Measures and Handling
- Use in a chemical fume hood; avoid dust formation and inhalation.
- PPE: lab coat, chemical-resistant gloves (e.g., nitrile), safety glasses/face protection; change gloves regularly.
- Storage: Tightly closed in amber containers, cool and dry; protect from light and oxidizers.
- Spills and waste: Absorb with inert material; collect as hazardous waste following local regulations.
Quality and Compliance
- HPC reference materials are produced under stringent quality controls, supplied with comprehensive Certificates of Analysis specifying purity, identity confirmation, concentration (for solutions), uncertainty, and storage guidance.
- Traceability to certified starting materials and gravimetric preparation ensures reliable quantification across batches.
Analytical Reference Materials from HPC Standards
- Neat reference materials and ready-to-use solutions in acetonitrile or methanol at application-relevant concentrations.
- Custom mixtures, alternative solvents, and concentration ranges on request to match your method and matrix.
- Homogeneity and stability assessed; packaging in amber ampoules or vials to ensure integrity throughout shelf life.
Applications for Laboratories
- Environmental monitoring: wastewater and surface water screening, industrial discharge compliance, sediment assessments.
- Industrial hygiene: air and surface monitoring in dye, pigment, and polymer facilities.
- Materials testing: migration/leachate studies from colored articles and polymer systems.
Related Compounds and Transformation Products
- Potentially relevant analytes: sulfoxide/sulfone analogs of Diaminodiphenyl sulfide; mono-acetylated and di-acetylated metabolites; structurally related aromatic diamines used in dyes and polymers.
- Including related targets in multi-residue methods can improve source attribution and risk assessment.
Documentation and Support
- Each product is delivered with a Certificate of Analysis and Safety Data Sheet.
- Technical support for method development, matrix-matched calibration, and uncertainty budgeting is available from our application specialists.
Ordering Information
- Product forms: neat solid, single-analyte solutions, and custom multi-analyte mixes.
- Typical pack sizes: 1–100 mg (neat) and 1–5 mL (solutions); other sizes on request.
- Lead times for custom configurations are minimized through flexible production and QC workflows.