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Methylaminoantipyrine hydrogen sulfate – Reference Materials for Residue Analysis
Methylaminoantipyrine hydrogen sulfate Precision Reference Materials for Confident Compliance
Secure robust LCMSMS quantification with highpurity methylaminoantipyrine MAA hydrogen sulfate from HPC Standards. Our certified reference materials deliver traceable calibration, rigorous purity assessment, and documented stability for regulatory residue monitoring of metamizole dipyrone in animal-derived foods and environmental samples. Available as neat material or readytouse solutions, they support method development, validation, and routine QC across complex matrices muscle, liver, kidney, milk, eggs, honey. Rely on ISO-aligned quality, comprehensive CoAs, and expert technical supportyour partner for defensible results and seamless audit readiness.
Product | Catalog No./ CAS No. | Quantity | Price | |
|---|---|---|---|---|
 | 693020 | 1X10MG | ||
4-Methylaminoantipyrine hydrogen sulfate solution |  | 693021 | 1X1ML | |
 | 693022 | 1X10MG | ||
D3-4-Methylaminoantipyrine hydrogen sulfate solution |  | 693023 | 1X1ML |
Reliable reference materials for the quantification of methylaminoantipyrine (MAA) hydrogen sulfate, the key marker metabolite of metamizole (dipyrone), supporting compliant food and environmental testing.
Overview
Methylaminoantipyrine (MAA) hydrogen sulfate is the sulfate salt of 4-methylaminoantipyrine, a primary marker metabolite of the analgesic veterinary drug metamizole (dipyrone). The hydrogen sulfate form offers improved aqueous solubility and handling, making it suitable as a calibration compound for LC–MS/MS residue methods.
As a marker residue, MAA is monitored in animal-derived foods (e.g., muscle, liver, kidney, milk) to verify compliance with national and international veterinary drug regulations.
Synonyms & Identity
Common names: 4-methylaminoantipyrine sulfate; MAA hydrogen sulfate; methylaminoantipyrine sulfate (acid sulfate). Parent drug: metamizole (dipyrone). Marker residues often include 4-methylaminoantipyrine (MAA) and 4-aminoantipyrine (AA).
Function in analysis: Quantitative reference for calibration, method validation, and quality control in residue monitoring of metamizole use in food-producing animals.
Uses
Laboratory application in targeted LC–MS/MS quantification of metamizole residues via MAA in complex matrices such as bovine, porcine, equine tissues, milk, eggs, and honey. Also used in incurred-sample confirmation and proficiency testing.
Supports development of screening and confirmatory methods, including multi-residue veterinary drug panels.
Regulatory Context
Regulatory frameworks for veterinary medicinal product residues (e.g., EU legislation under Regulation (EC) No 470/2009 and listings such as Commission Regulation (EU) No 37/2010) identify marker residues and set maximum residue limits (MRLs) or prohibitions by species/use. Many jurisdictions specifically monitor MAA (and AA) as marker metabolites of metamizole in edible tissues and milk.
Requirements include validated analytical methods, traceable calibration, and demonstration of decision limits (CCα) and detection capabilities (CCβ) consistent with official guidance.
Monitoring
Routine surveillance programs emphasize high-sensitivity quantification of MAA in animal-derived foods. Laboratories implement selective sample preparation (protein precipitation, SPE or QuEChERS adaptations) with matrix-matched calibration and internal standardization.
Confirmatory criteria typically include multiple MRM transitions, ion ratio tolerances, retention time matching, and recovery/precision within method performance limits.
Analytical Methods
Preferred technique: LC–MS/MS with positive electrospray ionization. Typical workflows use reversed-phase chromatography with volatile buffers (e.g., formate or acetate) for robust peak shape and ionization efficiency.
Method validation should cover linearity across relevant ranges (e.g., sub-µg/kg to low mg/kg), matrix effects, extraction recovery, selectivity, precision, accuracy, stability, and uncertainty budgeting in accordance with SANTE/ISO guidance.
Analytical Standards
HPC Standards provides certified reference materials for methylaminoantipyrine hydrogen sulfate suitable for calibration, system suitability, and quality control. Formats include neat material and ready-to-use solutions upon request.
Traceability to international measurement systems, rigorous purity assessment, and documented stability support defensible results in regulatory testing. Stable isotope–labelled internal standards for related analytes can be supplied to improve accuracy and compensate for matrix effects.
Sample Matrices
Common matrices: bovine, porcine, and equine muscle; liver; kidney; milk; eggs; honey; and animal feed. Method adaptations may be required to address matrix-specific interferences and recovery.
Matrix validation should demonstrate compliance at relevant action limits or MRLs with robust performance across batches.
Quality & Compliance
Our reference materials are tested according to international quality requirements and meet high industrial standards, enabling accreditation to ISO/IEC 17025 and alignment with ISO 17034 principles through traceable calibration and well-defined uncertainties.
Comprehensive documentation (CoA, intended use, storage, and stability) supports audits and data defensibility.
Health Impact
MAA is a pharmacologically active metabolite of metamizole. Human exposure via residues is regulated to minimize risk. Analytical control ensures that residues in food remain within legal limits or are absent where the substance is not permitted.
Risk management is based on toxicological evaluation of the parent drug and marker residues, applying conservative safety factors and monitoring programs.
Environmental Impact
Veterinary drug metabolites, including MAA, may enter the environment through manure and wastewater. Fate processes include dilution, sorption, biotransformation, and photolysis. Environmental concentrations are typically low but are monitored in some programs to assess potential exposure.
Good veterinary practices and waste management reduce environmental loading.
Safety Measures (Laboratory)
Handle reference materials with standard laboratory precautions: use PPE, avoid inhalation and skin contact, and work in well-ventilated areas. Follow SDS guidance for spill response and disposal in accordance with local regulations.
Prevent cross-contamination by dedicating glassware, using cleanroom-grade solvents, and implementing carryover checks in autosamplers.
Stability & Storage
Store solutions refrigerated or frozen as indicated on the CoA/SDS, protected from light and moisture. The hydrogen sulfate salt provides enhanced solubility and can improve solution stability under recommended conditions.
Monitor expiry dates and perform periodic QC checks (e.g., response factors, purity assessments) for long-running methods.
Why HPC Standards
We specialize in reference materials for pesticides, veterinary drugs, their metabolites, and stable isotope–labelled derivatives. Our products enable precise, reproducible quantification for food and environmental analysis, ensuring compliance with regulatory limits and audit-ready documentation.
Technical support is available for method development, matrix challenges, and selection of suitable internal standards.