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Nifuraldezone — Reference Materials for Residue Analysis
Nifuraldezone High-Purity Reference Materials for Confident LCMSMS Residue Control
Ensure defensible results in food and environmental testing with HPC Standards Nifuraldezone reference materials. Certified content, full CoA, and traceable characterization support calibration, validation, and ongoing QC at subgkg to low gkg levels. Available as neat or readytouse solutions, with matrix-matched options and stable isotopelabelled internal standards where available. Compliant with international quality requirements, our materials enable zerotolerance surveillance, supplier verification, and official control programs across aquaculture, meat, dairy, honey, and environmental matrices. Expert technical support helps you optimize LCMSMS workflowsfrom method setup to troubleshootingfor reliable, regulatoryready results.
Product | Catalog No./ CAS No. | Quantity | Price | |
|---|---|---|---|---|
ISO 17034 Reference Material |  | 693010 | 1X5MG | |
ISO 17034 Certified Reference Material 15N3-Nifuraldezone solution |  | 693011 | 1X1ML | Please log in. |
ISO 17034 Reference Material |  | 692994 | 1X5MG | |
ISO 17034 Certified Reference Material Nifuraldezone solution |  | 692995 | 1X1ML | Please log in. |
High-purity reference materials for Nifuraldezone to support sensitive, reliable residue determination in food and environmental matrices. Certified content, full documentation, and expert support for compliant LC-MS/MS methods.
Overview
Nifuraldezone is a nitrofuran-class compound historically used as an antimicrobial in veterinary medicine. Nitrofuran drugs and their residues are of high regulatory concern due to genotoxic and carcinogenic potential. Residue control focuses on highly persistent protein-bound metabolites in edible tissues, as well as potential parent-compound contamination in products and environments associated with animal production and aquaculture.
HPC Standards GmbH provides reference materials for Nifuraldezone to enable accurate calibration, method validation, and ongoing quality control in residue analysis.
Uses
Historically: antimicrobial treatment in food-producing animals (e.g., poultry, swine) and aquaculture. Many jurisdictions have banned or severely restricted nitrofurans, including Nifuraldezone, leading to zero-tolerance policies for residues in food.
Current relevance: surveillance of illegal use, verification of supplier compliance, and environmental monitoring near intensive farming or aquaculture facilities.
Regulatory
European Union: nitrofurans are prohibited in food-producing animals; control plans typically apply a practical minimum required performance limit (MRPL) in the low µg/kg range for marker residues of the nitrofuran class. Analytical performance and confirmation commonly follow EU criteria for residue methods and confirmatory mass spectrometry.
United States and many other markets: prohibition of nitrofurans in food animals; zero tolerance for residues with enforcement via confirmatory LC-MS/MS.
Food business operators and official labs are expected to apply validated methods with traceable calibration and fit-for-purpose measurement uncertainty.
Monitoring
Target matrices: aquaculture products (e.g., shrimp, fish), poultry, pork, bovine, honey, eggs, milk, and processed foods containing animal-derived ingredients. Environmental samples (surface water, sediments, sludge) may be monitored near production sites.
Analyte focus: parent Nifuraldezone (where relevant) and class-specific marker metabolites typical for nitrofuran exposure. Laboratories often implement derivatization workflows for bound metabolites alongside direct LC-MS/MS for parent compounds in appropriate matrices.
Health Impact
Nitrofurans are associated with genotoxicity and carcinogenicity in experimental systems. Their tissue-bound metabolites are persistent and may remain detectable long after administration. Risk management strategies therefore adopt precautionary, zero-tolerance approaches in many regions.
Environmental Impact
Potential persistence and mobility in aquatic systems with associated toxicity to aquatic organisms. Environmental monitoring programs may include screening of effluents and sediments in areas with high risk of misuse or legacy contamination.
Safety Measures
Laboratory handling: treat Nifuraldezone as potentially hazardous. Use appropriate PPE (lab coat, gloves, safety glasses) and work in a fume hood when preparing solutions. Avoid skin contact and inhalation. Dispose of waste in accordance with institutional and local regulations.
Storage: protect from light; store tightly closed at controlled temperature as stated on the certificate of analysis (CoA). Avoid repeated freeze–thaw cycles; open only under dry, clean conditions.
Analytical Reference Materials
HPC Standards GmbH supplies neat and solution-based reference materials for Nifuraldezone designed for calibration, system suitability, method validation (linearity, trueness, precision), and ongoing quality control.
Available options include: single-analyte solutions in common LC-MS solvents, neat materials for in-house preparations, matrix-matched solutions on request, and stable isotope-labelled internal standards for isotope-dilution workflows (where available).
Analytical Methods
Typical determination by LC-MS/MS using reversed-phase chromatography and electrospray ionization. Parent-compound analysis may be complemented by derivatization-based workflows for nitrofuran marker metabolites to ensure comprehensive surveillance.
Sample preparation approaches include protein precipitation, SPE cleanup, or QuEChERS adaptations for animal-derived matrices. Validated methods achieve sub-µg/kg to low µg/kg LOQs depending on matrix and instrumentation.
Quality and Documentation
Each reference material is supplied with a CoA detailing identity confirmation, assigned content (with uncertainty), solvent, lot number, storage conditions, and shelf life. Materials are tested according to international quality requirements and meet the highest industrial standards to support defensible results in regulatory contexts.
Applications
- Quantitative calibration for LC-MS/MS residue screening and confirmation
- Method development and validation (specificity, linearity, recovery, matrix effects)
- Internal quality control charts and proficiency testing
- Supply-chain verification and official control programs
Product Features
- High-purity reference materials with traceable characterization
- Ready-to-use solution formats and customizable concentrations
- Optional custom mixtures to cover multi-residue screening
- Technical support for method setup and troubleshooting
Matrices and Sectors
Food: aquaculture products, meat, honey, eggs, dairy, gelatin, and processed foods. Environmental: water, sediments, sludge. Applicable for private laboratories, official control laboratories, and QA/QC units within the food industry and contract testing organizations.
Ordering and Support
Contact HPC Standards GmbH for product selection, bulk or custom formats, and technical documentation. Our specialists support you with method recommendations, stability information, and integration of reference materials into your accreditation framework.