Propanethiol (Propan-1-thiol, n-Propylthiol) — Reference Materials for Analytical Quality Assurance
Propanethiol — High-Purity Reference Materials for Confident Residue Analysis
Ensure accuracy from calibration to routine QC with HPC Standards’ high-purity propanethiol (Propan-1-thiol) reference materials. Manufactured to stringent international requirements and supplied with full documentation (CoA, SDS, traceability), our neat and certified solution formats are optimized for GC-based workflows in food, environmental, and occupational hygiene laboratories. Benefit from lot-specific characterization, reliable stability, and expert technical support for method validation, regulatory compliance, and ongoing QA/QC—your partner for precise monitoring of volatile reduced sulfur compounds and process impurities.
Product | Catalog No./ CAS No. | Quantity | Price | |
|---|---|---|---|---|
 | 688583 | 1X1000MG | Please log in. | |
 | 676610 | 1X250MG | Please log in. |
HPC Standards provides high-purity propanethiol reference materials with full documentation for calibration, method validation, and routine quality control in food, environmental, and occupational hygiene laboratories.
Overview
Propanethiol (C3H8S; CAS 107-03-9) is a low-boiling thiol used primarily as a chemical intermediate, including as a feedstock in insecticide synthesis. It is a colorless to pale yellow liquid with an intense, cabbage-like odor, high volatility, and high flammability.
Key identifiers: EC 203-455-5; PubChem CID 7848; UN 2402 (flammable liquid).
Physicochemical Properties
Molecular formula: C3H8S; Molar mass: 76.16 g/mol; Structure: CH3–CH2–CH2–SH (thiol functional group).
Boiling point: 67–68 °C; Melting point: −113 °C; Density: ~0.84 g/mL (20 °C); Water solubility: slight; Vapor pressure: ~155 mmHg (20–25 °C).
Flash point: approx. −21 °C (closed cup). Highly flammable liquid and vapor; strong, persistent odor.
Uses
- Chemical intermediate and feedstock for insecticide manufacture.
- Process chemistry and catalysis studies involving thiols and sulfur chemistry.
- Method development and instrument calibration for volatile reduced sulfur compounds (VRSC) in occupational and environmental monitoring.
Regulatory Classification
- GHS/CLP: Signal word Danger; example hazard statements include H225 (Highly flammable liquid and vapor), H302 (Harmful if swallowed), H319 (Causes serious eye irritation). Always consult the current SDS for applicable classifications.
- Transport: UN 2402; Flammable liquid (ADR/RID/IMDG/IATA). Follow modal regulations for packaging, labelling, and documentation.
- REACH/OSHA: Subject to general chemical safety, classification, and communication duties under EU REACH/CLP and OSHA HCS where applicable.
Occupational Exposure and Monitoring
- NIOSH REL (ceiling): 0.5 ppm (1.6 mg/m³) over 15 minutes (check latest guidance for jurisdiction-specific OELs).
- Workplace air monitoring: sampling on sorbent tubes (e.g., activated charcoal) with solvent desorption and GC-FID/GC–MS; thermal desorption tubes for VOC screening; headspace/HS-SPME GC for process emissions and indoor air.
- Calibration and QC: use matrix-appropriate reference materials for multi-point calibration, verification, and drift control.
Health Impact
- Human toxicity: Irritating to eyes and mucous membranes; harmful if ingested; strong odor detectable at very low concentrations may cause nausea or headache in sensitive individuals. High vapor concentrations can cause central nervous system effects and respiratory irritation.
- Acute exposure management: Move to fresh air, rinse eyes/skin as indicated on SDS, and seek medical advice for persistent symptoms. Follow site-specific emergency procedures.
Environmental Impact
- Volatile reduced sulfur compound (VRSC) contributing to odor nuisance; readily partitions to air due to high vapor pressure.
- Limited water solubility; potential for aquatic toxicity should be assessed per local regulations and site conditions.
- Combustion or thermal decomposition can release irritating/toxic sulfur oxides.
Safety Measures
- Engineering controls: Use in closed systems or fume hoods with adequate ventilation; implement vapor/odor containment.
- Personal protective equipment: Chemical splash goggles, suitable gloves (e.g., tested against thiols/solvents), lab coat; flame-resistant PPE in handling areas as required.
- Fire and explosion: Keep away from heat, sparks, open flames; use intrinsically safe equipment and proper grounding/bonding. Store in flammable liquids cabinets.
- Spill response: Evacuate area, eliminate ignition sources, contain and absorb with inert material, dispose per regulations; control vapors and odors.
Storage and Handling
- Store tightly sealed in original container at 2–8 °C or per SDS, under inert atmosphere where feasible to minimize oxidation and odor release.
- Segregate from oxidizers and strong acids/bases. Use compatible caps/liners; minimize headspace and repeated opening due to volatility.
Analytical Methods
- GC-FID/GC–MS for quantification in air and process samples; purge-and-trap or headspace techniques for volatile matrices.
- Derivatization can be applied when needed for specific matrices (e.g., alkylation) but direct analysis is common for volatile thiols.
- Recommended to verify method performance (linearity, recovery, LOD/LOQ, precision) with certified reference materials and matrix-matched QC.
Analytical Reference Materials from HPC Standards
- Product formats: neat material and ready-to-use certified solutions at various concentration levels tailored for GC-based workflows.
- Documentation: Certificate of Analysis (purity/assay, expanded uncertainty, traceability), Safety Data Sheet, and stability information.
- Quality: Manufactured under stringent quality requirements; lot-specific characterization aligned with international standards for reference materials.
Method Validation and QA/QC
- Use multi-level calibration with independent check standards; include blanks and duplicates to control carryover and memory effects common to odorous thiols.
- Employ ongoing QC (control charts, system suitability, retention time/response criteria) to track volatility-related losses and ensure compliance.
Applications in Food and Environmental Analysis
- Environmental and occupational air surveillance around synthesis and formulation sites.
- Odor impact assessments and VRSC source apportionment in industrial settings.
- Process control and impurity profiling in insecticide intermediate production.
Manufacture and Origin
- Industrial synthesis typically via anti-Markovnikov addition of hydrogen sulfide to propene (UV-initiated) or reaction of sodium hydrosulfide with 1-chloropropane.
- These routes inform impurity profiles; HPC Standards provides batch-specific characterization for reliable calibration.
Compliance and Documentation
- Supplied with CoA including purity determination, uncertainty, and metrological traceability; SDS aligned with GHS/CLP.
- Supports accreditation needs (e.g., ISO/IEC 17025 laboratories) through robust documentation and lot-to-lot consistency.
Packaging and Shipping
- Packed in airtight, chemically compatible vials to minimize permeation and odor; optional ampoules for long-term stability.
- Shipped as dangerous goods according to ADR/IMDG/IATA; temperature-controlled options available where required.
Why HPC Standards
- Expertise in pesticides, veterinary compounds, metabolites, and sulfur-containing analytes.
- Technical support for method development, matrix selection, and regulatory alignment across food and environmental sectors.