Methoxy-1,4-dioxane – Reference Materials for Regulatory Residue Analysis

Methoxy-1,4-dioxane Precision Reference Materials for Confident Compliance

Strengthen your residue testing with ISO-aligned Methoxy-1,4-dioxane reference materials from HPC Standards. Our high-purity, traceable standards enable reliable calibration, method validation, and routine QAQC across environmental, industrial, and product-quality matrices. Delivered with comprehensive documentation and produced to international quality requirements, they support GC-MSLC-MS workflows, isomer-specific selectivity, and defensible audit trails. Request custom concentrations, solvent systems, multi-analyte mixes, or stable isotope-labeled analogues to optimize sensitivity and accuracy. Partner with HPC Standardsyour expert in high-purity reference materials for robust, regulatory-ready results.

Product		Catalog No./ CAS No.	Quantity	Price
2-Methoxy-1,4-dioxane		691451 20732-36-9	1X10MG	Please log in.

Ensure accuracy and traceability in residue monitoring with ISO-compliant reference materials for Methoxy-1,4-dioxane from HPC Standards GmbH.

Overview

Methoxy-1,4-dioxane refers to methoxy-substituted derivatives of 1,4-dioxane (commonly designated as 2-methoxy-1,4-dioxane). It is a cyclic acetal/ether within the dioxane family, characterized by high polarity relative to typical ethers and full miscibility with many organic solvents. In analytical contexts, it may occur as a process-related impurity, solvent-related residual, or transformation product in industrial and environmental matrices.

Due to its structural similarity to 1,4-dioxane, the compound is of interest for monitoring programs addressing solvent residues, by-products, and potential contaminants in environmental and product quality control workflows.

Chemical Identity and Properties

• Substance class: Methoxy-substituted cyclic diether (1,4-dioxane core).
• Typical synonyms: 2-Methoxy-1,4-dioxane; 1,4-dioxane, 2-methoxy- (nomenclature may vary).
• Key attributes: Volatile/semi-volatile ether, high solvent affinity, water miscibility typical for dioxane derivatives, good GC amenability; stability influenced by moisture, heat, and light.

Note: Exact identifiers (CAS, EC) and thermophysical properties should be verified against authoritative chemical databases for the specific isomer supplied.

Uses and Sources

• Potential intermediate or solvent auxiliary in fine chemicals, polymers, and specialty synthesis routes.
• Possible by-product from acetalization/etherification processes.
• May appear as a residual in manufacturing streams, reagents, or formulated products if used upstream.

These use patterns inform risk-based monitoring in raw materials, intermediates, finished products, and waste streams.

Occurrence and Exposure Pathways

• Environmental: Release via industrial effluents or improper waste handling; potential presence in wastewater and surface waters.
• Workplace: Inhalation and dermal exposure during handling of solvents or intermediates.
• Products: Trace residuals in process streams or materials if not properly controlled.

Regulatory Status

• Substance-specific listings for Methoxy-1,4-dioxane may be limited; oversight often aligns with frameworks addressing volatile organic compounds (VOCs), industrial chemicals, and solvent residues.
• Related regulatory touchpoints: environmental discharge permits, workplace exposure standards, product quality and impurity limits (sector-specific), and safety data requirements.

Stakeholders should consult current regional regulations (e.g., EU REACH/CLP, US EPA/TSCA, national occupational limits) and product-category guidance for applicable thresholds and reporting obligations.

Monitoring and Analytical Methods

• Target analyte: Methoxy-1,4-dioxane (isomer-specific where relevant).
• Preferred techniques: GC-MS or GC-MS/MS (direct injection, headspace, SPME, or purge-and-trap depending on matrix and volatility). LC-MS/MS can be applied where chromatographic compatibility and ionization are validated.
• Sample preparation: Headspace/SPME for volatile matrices; liquid–liquid extraction or solid-phase extraction for aqueous samples; QuEChERS-like approaches for complex matrices when compatible.

Method optimization focuses on selectivity for the methoxy-substituted isomer versus 1,4-dioxane and other ethers, minimizing matrix effects, and validating recovery across concentration ranges relevant to regulatory or internal specifications.

Method Performance and QA/QC

• Validation parameters: Linearity, LOD/LOQ, accuracy, precision, recovery, specificity, robustness, and uncertainty estimation.
• Controls: Use of traceable reference materials for calibration and verification; matrix-matched calibration; internal standards (including structurally related or stable isotope-labeled analogues where available).
• Routine QA/QC: System suitability, blank checks, recovery spikes, and ongoing calibration verification.

Target Matrices

• Environmental: Wastewater, groundwater, surface water, influent/effluent, sludge extracts.
• Industrial: Process streams, intermediates, solvents, resins, and polymer-related matrices.
• Product quality: Raw materials and formulations where solvent-related impurities may occur.

Storage and Stability

• Store sealed in inert-compatible containers, protected from light and moisture, at controlled temperature per Safety Data Sheet guidance.
• Minimize headspace and repeated freeze–thaw cycles; document stock solution preparation, expiry, and traceability for compliance.

Health Impact

• Human toxicity: Methoxy-substituted dioxanes may exhibit irritation to eyes, skin, and respiratory tract on acute exposure; central nervous system effects are possible at elevated concentrations typical of ethers/solvents.
• Repeated exposure: Monitor for potential liver and kidney effects as observed with structurally related ethers; apply conservative occupational controls in absence of substance-specific OELs.
• Sensitization: Not classically associated, but evaluate per CLP/OSHA criteria during classification.

Occupational Safety

• Engineering controls: Local exhaust ventilation and closed handling systems for bulk operations.
• PPE: Chemical-resistant gloves, goggles/face protection, lab coat/coveralls; respiratory protection as indicated by risk assessment.
• Hygiene: Avoid inhalation and skin contact; implement spill control and waste management procedures; provide training and SDS access.

Environmental Impact

• Fate: High solubility and mobility possible; biodegradation potential depends on substitution; evaluate persistence and potential for transport to groundwater.
• Effects on wildlife: Acute and chronic toxicity data may be limited; apply precautionary measures aligned with analogous dioxane derivatives and local discharge limits.

Risk Management and Mitigation

• Implement source control and closed-loop solvent recovery where feasible.
• Treat wastewaters using advanced oxidation or tailored adsorption where conventional treatment is insufficient.
• Establish specification limits for process residuals and apply routine monitoring with fit-for-purpose methods.

Compliance and Reporting

• Align internal specifications with current regulatory expectations and customer requirements.
• Use traceable reference materials for defensible data and audits.
• Maintain method validation files, calibration records, and chain-of-custody for samples and standards.

Analytical Reference Materials

HPC Standards GmbH supplies certified reference materials for Methoxy-1,4-dioxane to support calibration, method validation, and routine QA/QC in environmental, industrial, and product quality laboratories. Materials are produced under rigorous quality systems and delivered with comprehensive documentation (certificate, purity profile, traceability, handling and storage guidance).

On request, we offer custom concentrations, solvent matrices, and multi-analyte mixes. Stable isotope-labeled analogues can be provided where available to enhance quantitative accuracy.

Applications for Industry and Laboratories

• Environmental monitoring: Wastewater and groundwater surveillance for solvent-related contaminants.
• Industrial QC: Verification of residual solvents/by-products in chemical manufacturing and polymer processing.
• Product stewardship: Supplier qualification, incoming goods control, and compliance testing across supply chains.

Why HPC Standards

• Expertise in reference materials for pesticides, veterinary drugs, metabolites, and related organics applicable to food and environmental analysis.
• Internationally aligned quality requirements and robust documentation for regulatory compliance.
• Technical support for method development, validation, and matrix challenges.