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Toluenesulfonamide – Reference Materials for Residue and Contaminant Analysis
Toluenesulfonamide Precision Reference Materials for Confident Compliance
Elevate your residue and contaminant analysis with highpurity toluenesulfonamide o-p-isomers reference materials from HPC Standards. Our LC-ready neat and solution formats enable accurate identification, isomer-resolved quantification, and robust method validation across environmental, food-contact, and industrial matrices. Each lot ships with a comprehensive CoA purity, identity, concentration, uncertainty, traceability to support ISOIEC 17025 workflows and regulatory reporting. Need tailored solutions Request custom mixes, concentrations, and solvent systems aligned to your LC-UV or LCMSMS methodsbacked by global logistics and stringent quality control.
Product | Catalog No./ CAS No. | Quantity | Price | |
|---|---|---|---|---|
 | 683498 | 1X1000MG | Please log in. | |
 | 692652 | 1X100MG | Please log in. |
High-quality reference materials for toluenesulfonamide (o-/p-isomers) supporting precise identification, quantification, and compliance across food, environmental, and industrial testing.
Overview
Toluenesulfonamide refers to a family of aromatic sulfonamides derived from toluene, predominantly the ortho- (o-) and para- (p-) isomers. These polar, water-miscible compounds are widely used as intermediates and performance additives and are frequently monitored as residues and contaminants in environmental and product safety testing.
As non-volatile, thermally stable analytes with good LC amenability, toluenesulfonamides are routinely analyzed by LC-UV or LC-MS/MS within multi-residue methods.
Chemical Identity & Isomerism
Primary analytes: o-toluenesulfonamide and p-toluenesulfonamide. Both share the toluene ring bearing a methyl substituent and a sulfonamide group; positional isomerism drives subtle differences in polarity, retention, and potential matrix interactions. Commercial and environmental samples may contain single isomers or o/p-mixtures.
Synonyms include o-/p-TSA and toluenesulphonamide (UK spelling). Accurate differentiation of isomers is recommended for regulatory reporting and source attribution.
Uses & Sources
- Intermediate in the manufacture of saccharin and other specialty chemicals.
- Plasticizer and resin modifier (e.g., for polyamides, coatings, adhesives); historically used in consumer formulations such as nail products.
- Potential contaminant in industrial effluents, landfill leachates, and wastewater; may occur as an impurity or degradation-related by-product in certain processes.
Regulatory Landscape
Regulatory status depends on application and jurisdiction (chemicals, consumer products, food-contact materials, environmental quality). Substance registration and notification frameworks (e.g., REACH-like schemes) generally apply to industrial use.
For laboratories, adherence to method validation guidance (e.g., SANTE/ISO/IEC, EPA/ASTM equivalents) is essential for reporting toluenesulfonamide residues in official control or compliance programs.
Monitoring & Target Matrices
- Environmental: surface water, groundwater, wastewater influent/effluent, sediments, landfill leachate.
- Food and contact materials: migration studies from coatings, adhesives, and packaging; targeted screening in complex food matrices where relevant.
- Industrial hygiene and product stewardship: raw materials, intermediates, and finished products.
Sample Preparation
- Aqueous matrices: direct injection (dilute-and-shoot) or SPE (mixed-mode/weak anion-exchange or reversed-phase) to reduce matrix effects.
- Solid/semi-solid matrices: solvent extraction (e.g., MeOH/ACN with water), optional salting-out or QuEChERS-style cleanup; SPE or dSPE for interferences.
- Include isomer-resolved workflows when reporting o-/p-TSA individually; apply matrix-matched calibration and internal standards to correct ion suppression/enhancement.
Analytical Methods
- LC-UV/FLD: suitable for higher-level screening and purity checks.
- LC-MS/MS: preferred for trace-level quantification; MRM transitions selected per instrument and ionization mode; typical reversed-phase gradients with aqueous buffer and organic modifier.
- Orthogonal confirmation: retention time matching with certified reference materials; ion ratio criteria and qualifier transitions as per regulatory guidance.
Calibration & Quantification
- Use multi-point calibration with bracketing; verify linearity or apply weighted regression where applicable.
- Employ isotopically labelled internal standards when available to correct matrix effects and improve accuracy and precision.
- Establish LOD/LOQ per matrix; routinely assess recovery, repeatability, intermediate precision, and measurement uncertainty.
Interferences & Specificity
- Co-eluting aromatic sulfonamides and formulation components may interfere in UV-based detection; MS/MS improves selectivity.
- Resolve o-/p-isomers chromatographically to prevent quantitation bias; optimize pH and gradient to control retention and peak shape.
Health Impact (Human Toxicity)
Toluenesulfonamides generally exhibit low acute toxicity but can cause irritation and, in susceptible individuals, sensitization. Occupational exposure should be minimized via engineering controls and PPE. Follow substance-specific SDS guidance for handling, first aid, and exposure limits when applicable.
Environmental Impact
- Mobility: polar character favors occurrence in aqueous compartments; potential transport in wastewater and groundwater.
- Persistence and fate: variable biodegradation depending on conditions; monitoring recommended in wastewater treatment and receiving waters.
- Effects on wildlife: assess on a case-by-case basis; implement precautionary discharge controls and environmental monitoring where industrial use is significant.
Safety Measures & Handling
- Use lab coat, gloves, and eye protection; avoid dust and aerosol formation.
- Work in well-ventilated areas or fume hoods; prevent release to the environment.
- Dispose according to local regulations and SDS instructions.
Storage & Stability
- Store reference materials in tightly closed containers, protected from light and moisture, at recommended temperatures indicated on the CoA.
- Use validated shelf-life and re-test dates; prepare and store working solutions under controlled conditions to maintain integrity.
Metabolites & Related Compounds
- Consider co-monitoring structurally related sulfonamides where relevant to source tracking or product stewardship.
- Include potential process impurities or degradation-related analytes depending on industrial context and regulatory scope.
Isotopically Labelled Reference Materials
Stable isotope-labelled analogues (when available) are recommended for internal standardization to improve recovery correction, compensate matrix effects, and meet stringent regulatory criteria for confirmatory analysis.
HPC Standards Reference Materials & Documentation
HPC Standards GmbH supplies high-purity reference materials for toluenesulfonamide (o-/p-isomers and mixtures) for reliable qualitative and quantitative analysis.
Each product is delivered with a Certificate of Analysis (CoA) detailing purity, identity confirmation, concentration (for solutions), uncertainty, and traceability according to international quality requirements.
Custom concentrations, solvent systems, and mixtures are available on request to align with your validated methods.
Quality & Accreditation
Our reference materials are produced under rigorous quality control and comply with international standards for manufacturing and testing. Batch-specific documentation supports audits, accreditation (e.g., ISO/IEC 17025 laboratories), and regulatory submissions.
Ordering & Logistics
- Formats: neat solids and ready-to-use solutions in common LC-MS compatible solvents.
- Packaging: amber glass vials with tamper-evident seals; lot-specific labeling for traceability.
- Global shipping with temperature-controlled options and compliant documentation for seamless import and laboratory receipt.