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Methylbenzophenone Reference Materials
Methylbenzophenone Precision Reference Materials for Confident Compliance
Drive reliable residue analysis with HPC Standards highpurity methylbenzophenone reference materials. Choose isomer-specific products 2-, 3-, 4-methylbenzophenone, neat or as certified readytouse solutions, including stable isotopelabelled derivatives for robust internal standardization. Each lot is meticulously characterized purity, identity, uncertainty, traceability to support ISOIEC 17025 and ISO 17034 workflows across food, packaging migration, and environmental matrices. Rely on proven LCMSMS, HPLCUV, and GCMS compatibilityand expert technical supportfor precise identification, quantification, and regulatory compliance.
Product | Catalog No./ CAS No. | Quantity | Price | |
|---|---|---|---|---|
 | 679332 | 1X250MG | Please log in. | |
 | 693709 | 1X100MG | ||
 | 687731 | 1X100MG | Please log in. |
High-quality reference materials for methylbenzophenone isomers to support precise identification, quantification, and regulatory compliance in food and environmental analysis.
Overview
Methylbenzophenone refers to a group of benzophenone derivatives bearing one methyl substituent on the aromatic ring (e.g., 2-, 3-, or 4-methylbenzophenone). These compounds are used as photoinitiators and UV absorbers and may occur as contaminants in foods via migration from printing inks and food-contact materials, as well as in environmental samples near production and waste streams.
HPC Standards provides meticulously characterized reference materials for methylbenzophenone (individual isomers on request) to ensure reliable residue analysis across diverse matrices.
Synonyms and Isomers
Common names: methylbenzophenone, methyl-diphenylmethanone, methyl-diphenyl ketone; often specified by position as 2-methylbenzophenone (o-), 3-methylbenzophenone (m-), and 4-methylbenzophenone (p-). Isomer-specific listings and CAS numbers differ by substitution pattern. Please specify isomer when ordering to match method requirements.
Physicochemical Profile
General characteristics: aromatic ketones with moderate hydrophobicity, low water solubility, and low volatility. They exhibit strong UV absorbance and photoreactivity relevant to their use as photoinitiators. Partitioning behavior supports accumulation in organic phases and solid matrices, influencing extraction and cleanup strategies.
Uses and Sources of Exposure
- Photoinitiator/UV-curable inks and coatings (printing on packaging materials)
- Additive in polymers and coatings; potential to migrate into foods under certain conditions
- Environmental presence near manufacturing, printing operations, and waste management sites
Regulatory Landscape
- Food-contact materials: Subject to EU and international frameworks governing printing inks and plastic materials; specific migration limits and risk assessments may apply. Operators should consult current EU regulation on plastic materials and articles intended to come into contact with food and national guidance on printing inks.
- Food safety: Monitoring in cereals, confectionery, and packaged foods has been requested by authorities following past notifications of migration from packaging.
- Environmental: May fall under national water and waste directives for industrial emissions and priority screening lists for organic contaminants.
Note: Check the latest regional legislation (EU, US, and other jurisdictions) for substance- and isomer-specific provisions and migration limits.
Monitoring and Compliance
- Food and food-contact: Surveillance of migration from packaging to food and food simulants; testing of finished products for residue compliance.
- Environmental: Screening of surface water, wastewater, sludge, sediments, and biota near industrial sources.
- Workplace: Air and surface monitoring in printing and curing operations as part of occupational hygiene programs.
Health Impact — Human Toxicity
Methylbenzophenone isomers share toxicological features with benzophenone-type compounds: potential for irritation, central nervous system effects at high exposure, and concerns over endocrine-related activity observed for some benzophenone derivatives in experimental systems. Exposure via diet is mainly linked to migration from packaging; risk management focuses on minimizing transfer and ensuring compliance with applicable migration limits.
Risk assessment should be isomer-specific where data are available; apply conservative limits in absence of definitive toxicological thresholds and follow the most recent regulatory guidance.
Environmental Impact — Effects on Wildlife
- Aquatic toxicity: Acute and chronic effects on algae, daphnia, and fish have been reported for structurally related benzophenones; sensitivity varies by species and isomer.
- Fate: Persistence is moderate with potential photodegradation under sunlight; adsorption to organic matter/sediment can be significant due to hydrophobicity.
- Bioaccumulation: Potential for accumulation is moderate; monitoring in aquatic environments and sediments is recommended near sources.
Sample Preparation and Matrices
- Foods: Extraction with acetonitrile or ethyl acetate; QuEChERS-based workflows with sorbent cleanup for high-fat or complex matrices.
- Food-contact materials: Migration testing using food simulants followed by LC–MS/MS analysis.
- Water and wastewater: Solid-phase extraction (SPE, e.g., C18, polymeric) with concentration and LC–MS/MS detection.
- Soils/sediments/sludge: Accelerated solvent extraction or ultrasonic extraction with nonpolar/medium polarity solvents; cleanup via silica/alumina or SPE.
Method Compatibility
- LC–MS/MS: Preferred for selectivity and sensitivity; multiple reaction monitoring of molecular ion and characteristic fragments.
- HPLC–UV/DAD: Suitable when higher LOQs are acceptable; leverage strong UV absorbance of benzophenone chromophore.
- GC–MS: Applicable depending on volatility/thermal stability; may require derivatization. Validate for isomer resolution if needed.
Quality and Accreditation
HPC Standards reference materials are produced and tested according to international quality requirements and meet the highest industrial standards. Where applicable, certificates provide purity, identity (NMR/HRMS), uncertainty, and traceability information to support ISO/IEC 17025 and ISO 17034 workflows.
Storage and Stability
Store neat solids or solutions tightly closed in amber containers at controlled room temperature or refrigerated as indicated on the CoA. Protect from light to prevent photodegradation. Allow solutions to reach ambient temperature before opening; minimize headspace and repeated freeze–thaw cycles.
Safety Measures
Handle in a fume hood with appropriate PPE (lab coat, safety glasses, nitrile gloves). Avoid inhalation of dust/vapors and skin contact. Prevent release to the environment. Refer to the Safety Data Sheet for detailed hazard and first-aid information.
Analytical Standards
Available products:
- Neat reference materials for methylbenzophenone (specify isomer)
- Ready-to-use certified solutions at custom concentrations in common solvents
- Stable isotope-labelled derivatives (where available) for internal standardization
Each product is accompanied by a Certificate of Analysis detailing identity, purity, and uncertainty to ensure reproducible quantification across batches and laboratories.
Documentation and Support
Provided documents: Certificate of Analysis, Safety Data Sheet, Technical Datasheet, and method guidance notes. Our technical team supports method development, matrix selection, and isomer-specific requirements.
Related Analytes
Benzophenone, hydroxybenzophenones, other photoinitiators and ink-related contaminants relevant to food-contact material assessments.