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Nitroaniline
Nitroaniline Reference Materials PRECISION for Isomer-Resolved Analysis
Accelerate confident compliance and method validation with high-purity nitroaniline isomer standards from HPC Standards. Our traceable 2-, 3-, and 4-nitroaniline reference materials deliver verified purity and concentration for reliable quantification across environmental, industrial, and product-residue matrices. Available as single-analyte or multi-isomer mixes, with custom solvents, concentrations, and optional isotope-labelled derivatives for LC-MSMS. Each lot is produced to international quality requirements, supplied with a comprehensive CoA, and shipped with full regulatory compliancesupporting calibration, system suitability, recovery studies, and ongoing QC in high-throughput B2B laboratories.
Product | Catalog No./ CAS No. | Quantity | Price | |
|---|---|---|---|---|
 | 682705 | 1X1000MG | Please log in. | |
 | 692620 | 1X250MG | Please log in. | |
 | 687818 | 1X10MG |
High-purity reference materials for nitroaniline isomers supporting precise quantification in environmental, industrial, and product-residue analysis. Manufactured and tested to international quality requirements for confident compliance and method validation.
Overview
Nitroaniline refers to a group of aromatic amines bearing one nitro (–NO2) and one amino (–NH2) substituent on a benzene ring. The three positional isomers are 2-nitroaniline (o-), 3-nitroaniline (m-), and 4-nitroaniline (p-). They are used as intermediates in dyes, pigments, agrochemicals, and pharmaceuticals and may occur as residues in industrial effluents, environmental matrices, and products.
Accurate measurement requires matrix-appropriate methods and traceable reference materials covering isomer specificity, purity, and concentration accuracy.
Chemical Profile
- Molecular formula: C6H6N2O2 (all isomers). Typical MW: 138.12 g/mol.
- Key functionalities: aniline (weak base), nitro group (strongly electron-withdrawing), enabling electrophilic substitution control and redox transformations (reduction to phenylenediamines).
- Physicochemical behavior (isomer-dependent): moderate polarity, limited water solubility; amenable to reversed-phase LC; thermally sensitive for GC unless derivatized.
Isomers and Synonyms
- 2-Nitroaniline (o-nitroaniline; CAS: 88-74-4)
- 3-Nitroaniline (m-nitroaniline; CAS: 99-09-2)
- 4-Nitroaniline (p-nitroaniline; CAS: 100-01-6)
Synonyms include nitrobenzenamine and aminonitrobenzene (position-specific).
Uses and Applications
- Intermediates for azo dyes, pigments, rubber chemicals, and pharmaceuticals.
- Precursors or transformation products in agrochemical synthesis pathways.
- Analytical targets in industrial hygiene, wastewater control, environmental monitoring, and product stewardship.
Regulatory Landscape
- Subject to chemicals management frameworks (e.g., EU REACH registration/CLP classification; comparable global schemes). Classification typically indicates acute toxicity and specific target organ effects; check current SDS for the isomer-specific hazard profile.
- Waste handling under hazardous waste regulations; effluent concentration limits may apply in permits for dye and chemical manufacturing sectors.
- Workplace control requirements under occupational exposure and hazard communication rules; implement engineering controls and exposure monitoring as needed.
Monitoring and Target Matrices
- Environmental: surface water, groundwater, sediment, wastewater, sludge.
- Industrial/process: reaction streams, intermediates, rinse waters, air (vapors/particulate-bound).
- Product/consumer safety: dyes, textiles, and materials where residual aromatic amines are restricted.
Health Impact – Human Toxicity
- Exposure routes: inhalation, dermal, oral (accidental). Absorption can lead to methemoglobinemia due to oxidative stress on hemoglobin.
- Acute effects: irritation to skin, eyes, and respiratory tract; cyanosis, headache, dizziness from methemoglobin formation at higher exposures.
- Repeated exposure: potential effects on blood and liver; isomer-specific data vary. Follow substance-specific SDS and occupational hygiene guidance.
Environmental Impact – Fate and Effects
- Fate: adsorption to organic matter; variable biodegradability depending on conditions (aerobic vs anaerobic). Nitro reduction to aminated products can occur microbially or abiotically.
- Persistence and mobility: moderate; potential to appear in industrial effluents if treatment is suboptimal.
- Ecotoxicity: toxic to aquatic organisms at elevated concentrations; implement source control and effective wastewater treatment.
Safety Measures and Handling
- Use closed systems and local exhaust ventilation; avoid aerosols and dust.
- Personal protective equipment: chemical-resistant gloves, lab coat, eye/face protection; use appropriate respiratory protection if airborne exposure may occur.
- Storage: tightly closed, light-protected, dry, and cool; segregate from strong oxidizers and reducing agents. Follow incompatibility information per isomer.
Methods of Analysis
- LC-UV/LC-DAD: suitable for screening and quantitation in water and product matrices; ensure isomer separation.
- LC-MS/MS: preferred for trace-level quantification in complex matrices; MRM transitions specific to each isomer.
- GC-MS: applicable after derivatization (e.g., silylation/acylation) to improve volatility and thermal stability.
- Sample preparation: SPE (C18/HLB), ion-pair SPE, or polymeric sorbents; for solids/sediments, accelerated solvent extraction or ultrasonic extraction followed by cleanup.
- Validation: assess isomer specificity, linearity, LOD/LOQ, recovery, matrix effects, and uncertainty using appropriate reference materials.
Reference Materials from HPC Standards
- High-purity reference materials for 2-, 3-, and 4-nitroaniline with traceable purity assignment and concentration verification.
- Custom concentrations and solvent matrices (e.g., acetonitrile, methanol, water/acetonitrile) in ampoules or vials.
- Multi-isomer mixes and, on request, stable isotope-labelled derivatives to support isotope dilution LC-MS/MS.
- Intended use: calibration, system suitability, method development, recovery studies, and ongoing QC in food, environmental, and industrial laboratories.
Storage and Stability
- Store at 2–8°C or as indicated on the label; protect from light. Avoid repeated freeze–thaw cycles.
- Observe shelf life and uncertainty budgets on the certificate; verify stability upon opening following good laboratory practice.
Quality and Accreditation
- Produced and tested according to international quality requirements to meet the highest industrial standards, ensuring reliability and reproducibility.
- Each batch is controlled for identity, purity, and concentration with documented measurement traceability.
Packaging and Formats
- Sealed ampoules or crimp vials; single-analyte or multi-component solutions.
- Typical fill volumes: 1–5 mL; custom pack sizes available for high-throughput labs.
Documentation and Traceability
- Supplied with a detailed Certificate of Analysis (CoA) including identity confirmation, purity data, concentration, uncertainty, and storage conditions.
- Lot-specific documentation supports audits, method accreditation, and regulatory submissions.
Shipping and Compliance
- Shipped under temperature-appropriate conditions with robust packaging.
- Hazard-compliant labeling and transport documentation according to current regulations.