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Drometrizole Trisiloxane – Reference Materials for UV Filter Analysis
Drometrizole trisiloxane High-Purity Reference Materials for Confident UV Filter Analysis
Ensure regulatory-ready results with HPC Standards traceable reference materials for drometrizole trisiloxane CAS 155633-54-8. Our certified neat and ready-to-use solutions deliver robust quantification across cosmetics, wastewater, and environmental matricesoptimized for LCMSMS and LCDAD workflows. Each batch includes a comprehensive CoA qNMRGC purity, MSUV identity, uncertainty and is backed by real-time stability data. Customize concentrations, solvent systems, and multi-analyte mixes stable isotope-labelled derivatives available on request. Rely on SI-traceability, stringent QAQC, and expert technical support to streamline calibration, verify label claims, and meet global compliance with confidence.
Product | Catalog No./ CAS No. | Quantity | Price | |
|---|---|---|---|---|
 | 684341 | 1X50MG | Please log in. | |
Drometrizole trisiloxane solution |  | 693836 | 1X5ML | Please log in. |
High-precision reference materials for the quantification of drometrizole trisiloxane in cosmetics, environmental, and wastewater matrices, supporting regulatory compliance and robust QA/QC.
Overview
Drometrizole trisiloxane (INCI: Drometrizole Trisiloxane; often known as Mexoryl XL) is a silicone-containing organic UV filter used in sunscreens and personal care products. It provides broad-spectrum protection, primarily in the UVB and short UVA (UVA-II) range, and is valued for strong photostability and formulation compatibility.
Key identifiers include CAS: 155633-54-8. The molecule is highly lipophilic, exhibits very low water solubility, and is commonly formulated in oil phases of cosmetic products.
Chemical Identity and Properties
- Function: Organic UV absorber (UVB and UVA-II)
- Structure: Benzotriazole chromophore functionalized with a trisiloxane moiety to increase lipophilicity and film-forming behavior
- Typical absorption maxima: approx. 300–305 nm (UVB) and 340–345 nm (UVA-II)
- Physical-chemical profile: very low aqueous solubility; high log Kow; high photostability; strong affinity for organic phases and particulate matter
Uses and Applications
- Primary use in sunscreens and daily-wear cosmetics (e.g., lotions, creams) to enhance broad-spectrum UV protection
- Often combined with other filters (e.g., avobenzone, bemotrizinol, octocrylene) to optimize SPF/UVA-PF and formulation stability
- Contributes to film formation and water resistance due to its siloxane backbone
Regulatory Status
- European Union (Cosmetics Regulation, Annex VI): Authorized UV filter; maximum concentration typically up to 15% w/w in finished cosmetic products
- Canada: Permitted as a UV filter in cosmetics, generally aligned with EU concentration limits
- United States: Not approved as an OTC sunscreen active under current monograph; use may be restricted to non-OTC cosmetic applications pending regulatory pathways
- Other jurisdictions: Check local cosmetics legislation for specific limits, labeling, and testing requirements
Monitoring and Compliance
- Product control: Verification of label claims and formulation consistency in finished cosmetics
- Environmental surveillance: Screening in influent/effluent, surface waters, sediments, and sludge due to wash-off from consumer use
- Supply chain QA: Incoming raw material identity/purity checks; batch release testing; trend analysis for stability
Health Impact (Human Toxicity and Exposure)
- Dermal exposure: Low systemic absorption expected due to high molecular size/lipophilicity; primarily remains on skin surface and within the formulation matrix
- Toxicological profile: Available data indicate low acute toxicity and good photostability; not classified as CMR under EU cosmetics framework at permitted use levels
- Sensitization/irritation: Generally low sensitization potential; standard cosmetic safety assessments apply
- Risk management: Safety-in-use is ensured via concentration limits, product-specific safety assessments, and post-market surveillance
Environmental Impact
- Fate: Strong sorption to organic matter and particulates; likely partitioning to sludge/sediments; persistence may be influenced by low water solubility and siloxane functionality
- Effects on wildlife: Potential risks to aquatic organisms cannot be excluded at elevated local concentrations; environmental monitoring programs treat UV filters as emerging contaminants
- Mitigation: Advanced wastewater treatment and source control via optimized formulations can reduce emissions
Safety Measures (Laboratory Handling)
- Handle reference materials in a fume hood with appropriate PPE (lab coat, safety glasses, nitrile gloves)
- Avoid inhalation of aerosols or dust; prevent release to the environment
- Protect from light and heat; use amber vials; minimize repeated freeze–thaw cycles
- Follow SDS guidance for storage, spill response, and disposal
Analytical Monitoring
- Target matrices: Finished cosmetic products, raw materials, rinse-off waters, influent/effluent, surface waters, sediments, sludge, biota extracts
- Typical concentration ranges: ng/L to µg/L in waters; mg/kg in solids/cosmetics
- Sample preparation: SPE (C18/HLB) for waters; LLE or QuEChERS-style extraction for complex matrices; cleanup via silica/Florisil if needed
- Detection: LC–MS/MS (often APCI+ or ESI+ depending on source optimization) for selectivity/sensitivity; LC–DAD/UV for screening leveraging strong UV absorbance; GC–MS may require derivatization and is matrix-dependent
Method Recommendations
- Chromatography: Reversed-phase LC (C18 or phenyl-hexyl); gradient elution with aqueous buffer and acetonitrile or methanol
- MS settings: Monitor characteristic precursor→product transitions; optimize source temperature and gas flows for low-volatility, lipophilic analytes
- Calibration: Multi-level external calibration with matrix-matched standards; internal standardization recommended (stable isotope-labelled analogue or structurally related surrogate)
- QA/QC: Method blanks, spiked recoveries, duplicates, and surrogates; evaluate matrix effects and extraction efficiency
Reference Materials from HPC Standards
- Formats: Neat solid and ready-to-use solutions in acetonitrile or methanol at defined concentrations
- Quality: Accompanied by Certificate of Analysis (purity by qNMR/GC, identity by MS/UV), measurement uncertainty, and traceability to SI where applicable
- Stability: Assigned shelf life based on real-time/accelerated studies; packaged in amber glass to ensure photoprotection
- Customization: Concentrations, solvent systems, and multi-analyte mixes available on request; stable isotope-labelled derivatives upon request
Application in Cosmetics Testing
- Assay of active content in finished products for regulatory compliance
- Stability studies under light/temperature stress to verify photostability within formulations
- Compatibility testing alongside other UV filters and antioxidants
Environmental Surveillance Use Cases
- Quantification in WWTP influent/effluent to assess removal efficiency
- Screening in surface waters and sediments near recreational areas
- Source apportionment in catchments impacted by seasonal sunscreen use
Storage and Stability Guidance
- Store at 2–8°C or as specified on the CoA/SDS; keep tightly closed and protected from light
- Allow solutions to reach room temperature before opening; record opening date for change-control
- Verify integrity periodically via system suitability and check standards
Documentation and Traceability
- Each batch supplied with CoA, SDS, and lot-specific purity/uncertainty data
- Change-control and lot-to-lot comparability supported for long-term monitoring programs
- Meets international quality requirements for reference materials used in regulated environments
Related Analytes
- Complementary UV filters: Avobenzone, Bemotrizinol, Octocrylene, Homosalate, Octisalate
- Degradation/transformation products may be monitored in advanced studies depending on treatment conditions
Ordering Information
- Pack sizes and concentrations suitable for routine QC and trace-level environmental analysis
- Expedite global shipping with temperature/light protection as required
- Technical support available for method development, matrix challenges, and selection of appropriate reference materials