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Quinolinol (Hydroxyquinoline) Reference Materials
Quinolinol Precision Reference Materials for Confident Compliance
Achieve robust identification, quantification, and regulatory alignment with HPC Standards highpurity Quinolinol hydroxyquinoline reference materials. We supply key isomers8hydroxyquinoline oxine, 2hydroxyquinoline, and 4hydroxyquinolineas neat solids or readytouse solutions, each delivered with a comprehensive certificate of analysis purity, identity, uncertainty. Optimized for LCUVFLD, LCMSMS, and derivatized GCMS, our standards support method development, validation, and routine QC across food, environmental, and industrial matrices. Benefit from internationally tested quality, customizable concentrations, and optional isotopelabelled derivatives or bespoke mixesso your lab meets limits, proves reliability, and accelerates timetoresult.
Product | Catalog No./ CAS No. | Quantity | Price | |
|---|---|---|---|---|
 | 675206 | 1X250MG | Please log in. | |
ISO 17034 Certified Reference Material 8-Quinolinol solution |  | 694371 | 1X5ML | Please log in. |
High-quality reference materials for quinolinol (hydroxyquinoline isomers) enabling precise identification, quantification, and regulatory compliance in food, environmental, and industrial product testing.
Overview
Quinolinol refers to hydroxy derivatives of quinoline, commonly known as hydroxyquinolines. Key isomers include 8-hydroxyquinoline (oxine), 2-hydroxyquinoline, and 4-hydroxyquinoline. These compounds are aromatic heterocycles with chelating properties toward metal ions and are analytes of interest in residue, biocide, and industrial product surveillance.
HPC Standards GmbH provides high-purity reference materials for quinolinol to support accurate method development, validation, and routine monitoring across diverse matrices.
Chemical Profile
Structure: quinoline backbone bearing one phenolic OH group (position-dependent isomers). The phenolic functionality and ring nitrogen confer acid–base behavior and strong metal chelation (notably for 8-hydroxyquinoline).
General traits: moderate lipophilicity, UV absorbance in the near-UV range, fluorescence in some isomers, tendency to form stable metal complexes, and light sensitivity in solution.
Applications and Uses
- Analytical reagent and chelating agent (e.g., 8-hydroxyquinoline in metal complexation and extraction chemistry).
- Active substance or component in biocidal, preservative, and antifungal formulations; derivatives (e.g., copper-8-quinolinolate) used for material preservation.
- Intermediate for pharmaceuticals and specialty chemicals; research analyte in coordination chemistry and materials science.
Regulatory Status
Regulatory oversight depends on the isomer and application (biocide, preservative, industrial chemical). In the EU, certain hydroxyquinoline substances are evaluated under the Biocidal Products Regulation; in the US, selected uses may fall under EPA pesticide/antimicrobial regulations. Product- and market-specific classifications (e.g., hazard labeling, product authorization) apply.
Residues in food are typically monitored when quinolinol-related substances are used in agricultural or post-harvest settings; applicable limits are jurisdiction- and commodity-specific.
Monitoring and Target Matrices
Typical matrices: food and feed (commodities, processed products), drinking and surface water, wastewater, soil and sediments, biocidal products, textiles, wood and paper, and industrial formulations.
Laboratory objectives: screening, confirmation, and quantitation for compliance, process control, product stewardship, and environmental fate studies.
Analytical Methods
- LC-UV/FLD and LC–MS/MS are primary techniques due to polarity and UV activity; ESI in positive or negative mode is used depending on isomer and mobile phase pH.
- GC–MS is feasible after derivatization (e.g., silylation or acylation) of the phenolic group to enhance volatility and stability.
- Metal–chelate detection: indirect determination via metal–quinolinol complexes (e.g., Cu/Al complexes) for specific applications.
- Identification relies on retention time, qualifier/quantifier ions or transitions, UV spectra, and, where applicable, fluorescence signatures.
Sample Preparation
- Aqueous matrices: solid-phase extraction (SPE; polymeric reversed-phase, mixed-mode) with pH control to manage ionization and chelation; avoid metal contamination of labware.
- Food and solids: QuEChERS-style extraction with buffered salts, followed by dSPE cleanup; consider matrix-matched calibration to mitigate ion suppression.
- Derivatization (for GC): silylation (e.g., BSTFA) or acylation post-extraction; ensure anhydrous conditions.
Health Impact — Human Toxicity
Hydroxyquinolines can cause irritation and exhibit systemic toxicity at elevated exposures; some isomers or salts have antimicrobial activity. Toxicological profiles vary by isomer and formulation. Risk depends on concentration, route, and duration of exposure; observe applicable workplace and product safety requirements.
Environmental Impact — Effects on Wildlife
Quinolinol compounds and their metal complexes may be hazardous to aquatic organisms. Chelation can alter bioavailability of metal ions. Environmental fate includes photolysis and biodegradation; persistence and mobility depend on isomer, pH, complexation, and matrix.
Stability and Storage
Store in tightly closed, amber containers, protected from light. Recommended storage at 2–8 °C for solutions; room temperature to cool conditions for dry materials, as specified on the certificate. Avoid contact with reactive oxidizers and unnecessary exposure to metal-containing surfaces due to chelation.
Safety Measures and Handling
Use appropriate PPE (lab coat, gloves, eye protection) and work in a fume hood. Prevent metal contamination of samples and standards. Follow spill and waste procedures for phenolic/heteroaromatic compounds and adhere to local regulations for disposal.
Compliance and Documentation
Use traceable calibration and documented validation (selectivity, linearity, accuracy, precision, LOQ/LOD, robustness). Maintain chain-of-custody for regulatory testing and apply matrix-matched or isotope-dilution calibration where appropriate.
Analytical Standards
HPC Standards GmbH supplies reference materials for quinolinol, including key isomers such as 8-hydroxyquinoline (oxine), 2-hydroxyquinoline, and 4-hydroxyquinoline. Materials are produced and tested according to international quality requirements and meet the highest industrial standards.
Available formats: neat solids and ready-to-use solutions in acetonitrile or methanol at customizable concentrations. Each item is accompanied by a certificate of analysis with purity, identity, and uncertainty data to support method validation and routine QC.
On request: isotope-labelled derivatives (where available), bespoke mixtures, stability studies, and matrix-matched spiking solutions for proficiency testing and interlaboratory comparisons.
Method Development Notes
- Control mobile phase pH to optimize retention and ionization; consider ammonium buffers compatible with MS.
- Monitor potential in-source complexation or adducts; use metal-free solvents and tubing when feasible.
- Employ internal standards (structural analogs or isotope-labelled) to correct for recovery and matrix effects.
Identifiers and Synonyms
Common synonyms: hydroxyquinoline(s); 8-hydroxyquinoline (oxine); 2-hydroxyquinoline; 4-hydroxyquinoline. Representative CAS numbers: 148-24-3 (8-hydroxyquinoline), 607-66-9 (2-hydroxyquinoline), 611-99-4 (4-hydroxyquinoline). Verify exact identifier per product before ordering.
Ordering Information
Products are supplied with batch-specific certificates, recommended storage conditions, and shelf-life statements. For custom concentrations, packaging, and mixtures tailored to your method, contact HPC Standards GmbH technical support.