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Haloxyfop-P-methyl Reference Materials
Haloxyfop-P-methyl High-Purity Reference Materials for Confident Residue Compliance
Ensure traceable, defensible data with HPC Standards certified Haloxyfop-P-methyl reference materials. Manufactured to international quality requirements, our neat and ready-to-use solutions enable precise quantification of the parent ester and haloxyfop acid across food and environmental matrices. Rely on comprehensive COAs, stability and homogeneity data, and optional stable isotope-labelled standards to strengthen method development, multi-point calibration, validation, and routine QC. Achieve SANTEISO-aligned LOQs and recoveries with LCMSMS-ready materialsdelivered with robust documentation and temperature-controlled logistics for uninterrupted compliance monitoring.
Product | Catalog No./ CAS No. | Quantity | Price | |
|---|---|---|---|---|
ISO 17034 Reference Material |  | 672858 | 1X100MG | Please log in. |
Haloxyfop-P-methyl solution |  | 674034 | 1X5ML | Please log in. |
ISO 17034 Certified Reference Material |  | 693738 | 1X50MG | Please log in. |
High-purity reference materials for precise quantification of Haloxyfop-P-methyl and related residues in food and environmental samples. Manufactured and tested to international quality requirements for reliable compliance monitoring.
Overview
Haloxyfop-P-methyl is the R-enantiomer methyl ester of the aryloxyphenoxypropionate (AOPP) herbicide haloxyfop. It is a selective, systemic, post-emergence grass herbicide used primarily in broadleaf crops. In plants and animals, the methyl ester is rapidly hydrolyzed to the active acid (haloxyfop), which is the principal residue of regulatory interest.
For residue analysis, laboratories require traceable, stable reference materials to support method development, validation, calibration, and routine quality control across diverse matrices.
Chemical Identity and Properties
Common name: Haloxyfop-P-methyl (R-enantiomer methyl ester of haloxyfop)
Functional group: Aryloxyphenoxypropionate (ACCase inhibitor)
General characteristics: hydrophobic ester; rapidly converts to haloxyfop acid in aqueous/biological systems; haloxyfop acid is weakly acidic and more polar.
Mode of Action and Uses
Mode of action: inhibition of acetyl-CoA carboxylase (ACCase), disrupting fatty acid biosynthesis in grasses (HRAC Group A).
Use pattern: post-emergence control of annual and perennial grasses in broadleaf crops (e.g., soybeans, oilseeds, legumes, beet, vegetables) and in non-crop areas.
Residue considerations: parent ester (haloxyfop-P-methyl), haloxyfop acid (free and conjugated forms), and formulation-related impurities may be relevant depending on jurisdictional residue definitions.
Regulatory and MRLs
Regulatory status varies by region; maximum residue limits (MRLs) are established for specific commodities and often refer to haloxyfop (sum of isomers, including relevant salts, esters, and conjugates, expressed as haloxyfop). Laboratories should consult current regulations (e.g., EU, EPA, Codex) for matrix-specific MRLs and residue definitions.
Compliance programs typically require validated methods with LOQs at or below regulatory limits and participation in proficiency testing where available.
Monitoring and Target Matrices
Typical matrices: fruits, vegetables, oilseeds, pulses, cereals, tea/herbal matrices, processed foods, animal commodities (where applicable), soil, surface water, and groundwater.
Target analytes: haloxyfop-P-methyl (parent), haloxyfop acid (free and conjugated; reported as haloxyfop after hydrolysis where required), and selected formulation impurities or metabolites per jurisdiction.
Analytical Methods
Chromatography: LC-MS/MS is preferred due to sensitivity and selectivity for both ester and acid forms. GC-MS may be used with derivatization for acidic residues.
Detection: MRM transitions optimized for haloxyfop-P-methyl and haloxyfop acid; negative ESI commonly used for the acid; positive ESI or APCI may be suitable for the ester.
Performance targets: typical LOQs ≤ 5–10 µg/kg in food matrices; method recoveries 70–120% with RSD ≤ 20% in accordance with SANTE/ISO guidelines.
Sample Preparation
Extraction: QuEChERS-based workflows or tailored acidic extraction for haloxyfop acid; maintain conditions minimizing ester hydrolysis if parent is measured.
Cleanup: dispersive SPE (PSA/C18/GCB as matrix-appropriate) or SPE cartridges for complex matrices.
Derivatization: optional for GC analysis of haloxyfop acid (e.g., methylation/silylation) when LC-MS/MS is not used.
Reference Materials from HPC Standards
HPC Standards provides certified reference materials for haloxyfop-P-methyl to support calibration, method validation, and routine QC. Materials are manufactured under rigorous quality systems, traceable to international standards, and supplied with comprehensive documentation (COA, homogeneity and stability data, uncertainty budget where applicable).
Available formats include neat materials and ready-to-use solutions at defined concentrations in suitable solvents, as well as matrix-appropriate mixtures on request.
Related Analytes and Metabolites
Complementary reference materials are available for haloxyfop (acid), other AOPP herbicides, and selected metabolites or conjugates as required by residue definitions. Stable isotope‑labelled derivatives can be provided to improve quantification and compensate for matrix effects.
Calibration and Quantification
Use multi-point calibration (at least 5–7 levels) bracketing the expected concentration range. Apply isotopic dilution or matrix-matched calibration to address ion suppression/enhancement.
Verify linearity, precision, accuracy, and measurement uncertainty. Include continuing calibration verification and fortified matrix QC samples in each batch.
Quality Assurance and Accreditation
Methods should follow recognized guidelines (e.g., SANTE/12682, ISO/IEC 17025). Validation parameters: selectivity, linearity, LOQ, trueness (recovery), precision (repeatability/reproducibility), matrix effects, and robustness.
Participation in interlaboratory comparisons/proficiency tests is recommended to demonstrate competency for haloxyfop residues.
Storage and Stability
Store reference materials in tightly closed, inert, amber containers at recommended temperatures (typically ≤ 4 °C for solutions; −18 °C for long-term storage). Avoid moisture and prolonged light exposure to minimize ester hydrolysis and photodegradation.
Observe stated shelf life and recheck concentration by comparison to fresh calibrators where long-term use is intended.
Health Impact (Human Toxicity)
Haloxyfop-P-methyl exhibits low to moderate acute toxicity. The acid metabolite may drive systemic effects observed in repeat-dose studies (e.g., liver weight/enzymatic changes) at elevated exposures. It is not generally considered genotoxic; carcinogenic classifications vary by authority.
Occupational exposure risks relate mainly to handling of concentrates and solvents; irritation to eyes/skin may occur. Follow SDS guidance strictly in laboratory handling.
Environmental Impact (Effects on Wildlife)
Haloxyfop esters hydrolyze to haloxyfop acid in the environment. The acid shows moderate persistence and mobility depending on soil characteristics. High acute toxicity to aquatic organisms has been reported for some formulations; risk assessments rely on proper use and mitigation.
Non-target plants (grasses) are sensitive due to ACCase inhibition; drift management is critical in agricultural use scenarios.
Safety Measures
Laboratory handling: use PPE (lab coat, nitrile gloves, eye protection) and work in a fume hood. Avoid inhalation, ingestion, and skin contact. Prevent contamination of food or feed.
Spill and waste: absorb with inert material and dispose as hazardous chemical waste in accordance with local regulations. Avoid release to drains/environment.
Shipping and Documentation
Reference materials are shipped under temperature-controlled conditions where necessary, with tamper-evident packaging. Each item is supplied with a certificate of analysis, safety data sheet, and handling instructions.
Applications in Food and Environmental Analysis
Use in regulatory compliance monitoring, method development for pesticide residue screening/confirmation, proficiency testing preparation, and internal quality control in ISO/IEC 17025 laboratories.
Applicable to surveillance of agricultural commodities, processed foods, drinking water, surface water, soil, and by-products along the agri-food supply chain.