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Neo Spiramycin I Reference Materials
Neo Spiramycin I Certified Reference Materials for Confident Compliance
Drive accurate quantification and confirmation with high-purity Neo Spiramycin I from HPC Standards. Our traceable, ISO-oriented reference materials empower LC-MSMS calibration, method validation, and ongoing QC in dairy and meat testing, as well as environmental monitoring. Manufactured and tested to international quality requirements, they support MRL compliance for macrolide residues, minimize matrix effects through matrix-matched calibration, and help prevent carryover with proven stability and lot-to-lot comparability. Choose HPC Standards for reliable results, faster audits, and uncompromising data integrity.
Product | Catalog No./ CAS No. | Quantity | Price | |
|---|---|---|---|---|
Neo Spiramycin I solution |  | 680513 | 1X1ML | Please log in. |
ISO 17034 Reference Material |  | 689347 | 1X5MG | Please log in. |
Certified reference materials for Neo Spiramycin I to support robust quantification and confirmation in food and environmental residue analysis. Manufactured and tested to international quality requirements for regulatory compliance.
Overview
Neo Spiramycin I is a macrolide antibiotic component related to spiramycin. It is monitored as a marker or associated compound in veterinary drug residue analysis due to its structural and pharmacological relation to spiramycin. Reliable determination of Neo Spiramycin I helps laboratories assess compliance with maximum residue limits (MRLs) and verify cleaning and carryover control in production environments.
Uses
Neo Spiramycin I is used as an analyte or marker in method development, calibration, and quality control for residue testing in food-producing animals and derived matrices (e.g., milk, meat, liver, kidney). It supports investigations of macrolide antibiotic presence and potential processing or degradation profiles related to spiramycin.
Regulatory Status
MRLs for macrolide antibiotics such as spiramycin are established in many jurisdictions (e.g., EU, Codex, national authorities). Neo Spiramycin I may be considered in confirmatory methods or as part of residue profiling where regulations require monitoring of parent drugs and related components. Specific limits and scope vary by region and matrix; laboratories should reference current legislation and guidance documents relevant to their market.
Monitoring and Control
Routine surveillance programs in the dairy and meat sectors frequently include macrolides due to their veterinary use and antimicrobial resistance concerns. Neo Spiramycin I reference materials enable calibration, system suitability, and ongoing performance verification in LC-MS/MS methods employed for screening and confirmatory testing.
Analytical Methods
- Primary technique: LC-MS/MS in positive electrospray ionization with multiple reaction monitoring (MRM) for selectivity and sensitivity in complex matrices.
- Typical workflows: QuEChERS-like or protein-precipitation extractions, followed by SPE or phospholipid clean-up as needed to mitigate matrix effects (especially in milk and tissues).
- Chromatography: Reversed-phase C18 columns with gradient elution using aqueous buffer (e.g., formic acid or ammonium formate) and organic modifier (acetonitrile or methanol). Attention to carryover and adsorption is recommended due to macrolide amphiphilicity.
- Quality controls: Use of matrix-matched calibration and stable isotope-labelled internal standards where available to correct for recovery and ion suppression/enhancement.
Sample Preparation and Matrices
- Milk: Protein precipitation (e.g., acetonitrile) with subsequent clean-up to reduce lipids; low-temperature centrifugation can improve phase separation.
- Meat and offal: Homogenization, solvent extraction, and SPE clean-up targeting macrolide polarity; validate recovery across tissues of differing fat content.
- Environmental samples: Solid-phase extraction from water or slurry with attention to pH and ionic strength to maintain analyte stability.
Health Impact
Neo Spiramycin I, as a macrolide-related compound, shares class characteristics with spiramycin in inhibiting bacterial protein synthesis. Human exposure via residues should remain below established MRLs to minimize risks such as allergic reactions or alterations of gut microbiota. Occupational exposure should be controlled to avoid sensitization.
Human Toxicity
Macrolides can cause gastrointestinal disturbances and, in sensitized individuals, hypersensitivity reactions. While specific toxicological thresholds for Neo Spiramycin I may not be individually established, adherence to regulatory residue limits for the macrolide group and parent spiramycin mitigates consumer risk. Laboratories should handle reference materials under appropriate safety protocols to avoid inadvertent exposure.
Environmental Impact
Macrolide antibiotics released into the environment can contribute to antimicrobial resistance selection pressures in microbial communities. Persistence varies with pH, temperature, and light; adsorption to sediments and organic matter can occur. Waste management practices should minimize discharge to wastewater.
Effects on Wildlife
Chronic low-level antibiotic exposure may impact microbial ecology in soil and aquatic systems, indirectly affecting nutrient cycles and food webs. While acute toxicity to higher organisms is generally low at environmental concentrations, precautionary handling and disposal reduce ecological risks.
Safety Measures and Handling
- Use PPE: lab coat, gloves, safety glasses; handle powders in a fume hood to prevent inhalation.
- Avoid skin and eye contact; prevent aerosol formation. Wash thoroughly after handling.
- Spill management: Collect mechanically, avoid dust, dispose according to local regulations for pharmaceutical substances.
Storage and Stability
- Store reference materials in original, tightly closed containers, protected from light and moisture, typically at 2–8°C or as stated on the certificate.
- Use aliquots to minimize freeze–thaw cycles for solutions. Verify stability statements and uncertainty data in the accompanying documentation.
Analytical Quality Assurance
- Employ certified reference materials for calibration and verification across the validated range.
- Implement system suitability tests (retention time, ion ratios, response factors) and ongoing QC (blanks, spikes, duplicates).
- Document traceability, measurement uncertainty, and lot-to-lot comparability in accordance with ISO/IEC 17025 and ISO 17034 principles.
Applications of Reference Materials
- Calibration curves for LC-MS/MS quantification of Neo Spiramycin I in milk, meat, and environmental matrices.
- Recovery studies, matrix effect evaluation, method validation (selectivity, linearity, precision, accuracy, LOQ/LLOD).
- Proficiency testing support and inter-laboratory comparisons.
Cross-Contamination Prevention
- Use dedicated glassware and low-adsorption vials; verify absence of carryover with stringent needle-wash protocols.
- Sequence design: Place strong wash and blanks after high standards and fortified samples.
Related Compounds
- Spiramycin (parent macrolide antibiotic)
- Other neospiramycin factors/components and macrolide-class analytes (e.g., tylosin, tilmicosin) that may be co-monitored depending on regulatory scope.
Synonyms and Identifiers
Common names: Neo Spiramycin I; Neospiramycin I; Neo-spiramycin factor I. Class: Macrolide antibiotic component related to spiramycin.
Why HPC Standards
HPC Standards GmbH manufactures and supplies traceable reference materials for Neo Spiramycin I to support residue analysis in food and environmental laboratories. Our materials are tested according to international quality requirements and meet the highest industrial standards, enabling reliable compliance testing and robust method performance.