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Sulfameter (Sulfamethoxydiazine, Sulfametoxydiazine)
Sulfameter Certified Reference Materials for Confident Compliance
Ensure accurate, reproducible quantification of Sulfameter residues with HPC Standards high-purity, traceable reference materials. Trusted by food and environmental laboratories, our Sulfameter CRMs support LC-MSMS workflows with matrix-matched calibration, isotopically labelled options, and batch-specific CoAs. Meet international quality requirements, align with global MRLs, and streamline method validationfrom meat, milk, and eggs to water and honey. Fast global delivery, custom concentrations, and expert technical support included.
Product | Catalog No./ CAS No. | Quantity | Price | |
|---|---|---|---|---|
 | 693150 | 1X10MG | ||
13C6-Sulfameter solution |  | 693151 | 1X1ML | |
 | 675356 | 1X250MG | Please log in. | |
Sulfameter solution |  | 679813 | 1X1ML | Please log in. |
HPC Standards provides certified reference materials for Sulfameter to support precise residue monitoring in food and environmental matrices. Our products meet international quality requirements and enable compliant, reproducible analytics.
Overview
Sulfameter (INN: sulfamethoxydiazine; USAN: sulfameter) is a long-acting sulfonamide antibacterial used in human and veterinary medicine. Due to its persistence, residues can occur in animal-derived foods and environmental samples, making robust residue analysis essential for compliance.
Key identifiers: CAS 651-06-9; IUPAC: 4-amino-N-(5-methoxy-2-pyrimidinyl)benzenesulfonamide; Molecular formula C11H12N4O3S; Molar mass 280.30 g/mol; ATC J01ED04.
Uses
Human medicine: historically as a leprostatic agent and for urinary tract infections (long-acting sulfonamide class).
Veterinary medicine: treatment and prevention of bacterial diseases in livestock. Its extended half-life contributes to detectable residues in meat, milk, and eggs if withdrawal periods are not observed.
Regulatory
Regulatory limits differ by jurisdiction. The Codex Alimentarius sets a maximum limit of 100 μg/kg for the sum of sulfonamides in animal tissues.
United States and Japan: sulfamethoxydiazine residues in food are prohibited.
EU and other markets: consult current MRL databases and national legislation; requirements may vary by species, tissue, and analytical scope (sum of sulfonamides vs. individual compounds).
Monitoring
Target matrices: muscle, liver, kidney, fat, milk, eggs, honey, feed, and water. Routine surveillance focuses on high-risk commodities from treated animals and processing environments.
Screening often employs class-based LC-MS/MS methods for sulfonamides; confirmatory methods quantify Sulfameter specifically with isotopically labelled internal standards.
Analytical Methods
Typical workflow: sample homogenization → protein precipitation and/or QuEChERS-type extraction → SPE cleanup (if required) → LC-MS/MS quantification in MRM mode.
Chromatography: reversed-phase LC with acidic mobile phases to improve retention and ionization of sulfonamides; detection in ESI positive mode is common.
Quality controls: matrix-matched calibration, isotopically labelled internal standards, procedural blanks, spikes, and recovery checks across representative matrices.
Matrices and Sample Preparation
Animal tissues: solvent extraction (e.g., acidified acetonitrile), salt-out partitioning, cleanup to reduce lipids and phospholipids.
Milk and eggs: protein precipitation, defatting, and SPE to mitigate matrix effects.
Environmental water: SPE enrichment (e.g., HLB) with attention to pH to retain sulfonamides.
Quality Assurance and Traceability
Use calibrated reference materials with traceable purity assignments and documented uncertainties.
Implement bracketing standards, system suitability tests, and ongoing calibration verification to ensure measurement trueness and precision.
Health Impact
Human toxicity: sulfonamides can cause hypersensitivity reactions in susceptible individuals; residue exposure is regulated to minimize risk. Persistent residues underscore the need for validated monitoring to protect consumers.
Risk management: adherence to withdrawal periods, veterinary stewardship, and robust analytical verification reduce human exposure.
Environmental Impact
Persistence allows transport to manure, soils, and waters. Detectable levels may contribute to antimicrobial selection pressure in environmental microbiota.
Effects on wildlife: potential sublethal impacts on microbial communities; continuous monitoring of receiving waters is recommended near intensive livestock operations.
Safety Measures
Laboratory handling: avoid inhalation and skin contact; use appropriate PPE (lab coat, gloves, eye protection) and handle powders in ventilated enclosures.
Waste management: dispose of sulfonamide-containing waste according to local regulations for pharmaceutical/chemical residues.
Storage and Stability
Store neat material and solutions protected from light, dry, and cool. For analytical solutions, use amber vials; verify stability at intended storage temperatures and define replacement intervals per internal SOPs.
Cross-Contamination Control
Prevent carryover by employing segregated preparation areas for standards and samples, dedicated glassware, and frequent instrument rinses. Include procedural blanks to verify absence of laboratory-introduced residues.
Related Compounds
Class: sulfonamides. Multi-residue methods may include structurally related agents; confirm identity by retention time and ion ratio criteria specific to Sulfameter.
Applications for Laboratories
Use cases: regulatory compliance testing, method validation/verification, proficiency testing, QC of food and feed, environmental surveillance, and research on fate and transport.
Performance targets: low μg/kg quantification in complex matrices with stringent identification criteria.
Analytical Reference Materials
HPC Standards supplies Sulfameter reference materials for calibration, system suitability, and quality control across food and environmental matrices.
Options typically include neat materials and ready-to-use solutions at defined concentrations. Stable isotope-labelled analogues for internal standardization can be provided where available.
Each reference material is delivered with a comprehensive Certificate of Analysis detailing purity, identity confirmation, uncertainty, and storage recommendations. Products are tested according to international quality requirements and meet the highest industrial standards.
Regulatory Support
Documentation packages support audits and accreditation needs. Guidance on method setup, calibration ranges, and matrix-matched validation is available on request.
For jurisdiction-specific MRLs and zero-tolerance policies, consult current regulatory databases (e.g., Codex, US, Japan) and align reporting limits accordingly.
Ordering Information
Available pack sizes and concentrations optimized for LC-MS/MS workflows. Custom concentrations and mixes on request.
Global shipping with temperature-appropriate packaging and batch-specific CoA. Technical support from experienced scientists in food and environmental analysis.