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Thymol sulfate potassium salt – Reference Materials for Residue and Metabolite Analysis
Thymol sulfate potassium salt Precision Reference Materials for Confident LCMSMS Quantification
Ensure traceable, regulatory-ready results with high-purity thymol sulfate potassium salt from HPC Standards GmbH. Our rigorously characterized reference materials deliver reliable identification, calibration, and quantification across urine, plasma, wastewater, and surface water. Optimized for negative ESI and high aqueous solubility, they support robust method development, validation, and routine monitoring under ISOIEC 17025 and SANTE guidance. Supplied with comprehensive CoA, documented uncertainty, and batch traceabilityplus custom concentrations, mixes, and isotope-labelled derivatives on request. Choose HPC Standards for consistent performance, audit-ready documentation, and seamless integration into your LCMSMS workflows.
Product | Catalog No./ CAS No. | Quantity | Price | |
|---|---|---|---|---|
 | 693076 | 1X5MG | ||
D7-Thymol sulfate potassium salt solution |  | 693078 | 1X1ML | |
 | 693081 | 1X5MG | ||
Thymol sulfate potassium salt solution |  | 693082 | 1X1ML |
High-quality reference materials for precise quantification of thymol sulfate (potassium salt) in biological and environmental matrices. Manufactured and quality-controlled by HPC Standards GmbH for regulatory-compliant residue analysis.
Overview
Thymol sulfate (potassium salt) is the phase II conjugate of thymol formed via sulfation. As a polar, anionic metabolite, it is a major excretion product in mammals and relevant in exposure assessment, pharmacokinetic studies, and environmental monitoring. The potassium salt enhances aqueous solubility and facilitates reproducible analytical workflows.
HPC Standards GmbH provides rigorously characterized reference materials for thymol sulfate potassium salt to support accurate identification, calibration, and quantification across complex matrices.
Chemical Profile
• Class: Phenolic sulfate conjugate (O-sulfate) of thymol, supplied as potassium salt.
• Properties: High water solubility; low volatility; anionic under physiological pH; suitable for LC–MS/MS analysis in negative electrospray mode.
• Stability: Sensitive to hydrolysis at extreme pH; stable under cool, dry, and light-protected storage conditions.
Applications and Uses
• Biomonitoring: Marker of thymol exposure in human and animal urine or plasma.
• Food and feed research: Metabolite profiling in controlled exposure studies.
• Environmental analysis: Occurrence studies in wastewater and surface waters as an indicator of usage and fate of thymol-containing products.
• Method validation: Recovery, linearity, accuracy, precision, and LOQ/LOD determination in LC–MS/MS assays.
Regulatory Context
• Thymol is authorized in various jurisdictions as flavoring, preservative, and biocidal active; its sulfate conjugate is relevant for metabolism and residue studies supporting risk assessment.
• Laboratories may use thymol sulfate reference materials to demonstrate compliance with international quality requirements (e.g., ISO/IEC 17025, SANTE/12682, FDA/ICH guidance) for method validation and routine monitoring.
• Documentation packages (CoA, traceability, uncertainty) support audit readiness and regulatory submissions.
Monitoring and Biomarkers
• Primary matrix: Urine (often highest levels as conjugate); plasma/serum for kinetic profiling.
• Direct quantification of conjugate avoids enzymatic hydrolysis bias and preserves metabolite-specific information.
• Time-resolved sampling enables assessment of exposure, metabolism, and elimination.
Sample Preparation
• Recommended approaches: Dilute-and-shoot for urine (when sensitivity permits) or solid-phase extraction (anion-exchange or mixed-mode) for complex matrices.
• Maintain low to neutral pH to prevent desulfation; avoid prolonged high-temperature steps.
• Include matrix-matched calibration and, where available, isotope-labeled reference materials to correct for matrix effects.
Analytical Methods (LC–MS/MS)
• Chromatography: Reversed-phase LC with aqueous-rich mobile phases; consider ion-pair-free methods to preserve MS compatibility. HILIC is an option for high polarity.
• Ionization/detection: ESI negative mode; monitor characteristic sulfate-related fragments (e.g., m/z losses associated with SO3 or HSO4− as applicable to instrument settings).
• System suitability: Assess retention time stability, peak symmetry, carryover, and ion suppression with post-column infusion or matrix factor studies.
Calibration and Quality Control
• Prepare multi-point calibration curves spanning expected concentrations; verify linearity with appropriate weighting.
• Employ independent QC levels (low/mid/high) and ongoing recovery checks to ensure method robustness.
• Use certified reference materials with stated purity, identity confirmation, and uncertainty for traceable quantification.
Storage and Stability
• Store neat material tightly sealed, cool (e.g., 2–8 °C or below), dry, and protected from light and moisture.
• Prepare working solutions in suitable aqueous media; refrigerate or freeze aliquots to minimize freeze–thaw cycles.
• Periodically verify stability via comparative response and purity checks.
Health Impact — Human Toxicity
• Thymol undergoes extensive phase II metabolism to thymol sulfate and glucuronide, increasing polarity and facilitating excretion.
• The sulfate conjugate generally exhibits reduced biological activity compared to the parent phenol; toxicological concern is typically lower than for thymol itself. Standard laboratory chemical hygiene practices remain required.
Environmental Impact — Fate and Effects
• Conjugated metabolites such as thymol sulfate are prevalent in wastewater and may undergo transformation (including possible deconjugation) in environmental compartments.
• Monitoring the conjugate supports a more complete mass balance for parent-compound usage and environmental exposure assessments.
Safety Measures and Handling
• Use gloves, lab coat, and eye protection; handle solutions in well-ventilated areas.
• Avoid extreme pH and elevated temperatures to prevent decomposition; dispose of waste according to institutional and local regulations.
• Refer to the Safety Data Sheet for hazard communication and first-aid guidance.
Matrix Compatibility
• Validated for urine and plasma; adaptable to wastewater, surface water, and laboratory exposure studies.
• Consider matrix effects; apply matrix-matched calibration and internal correction strategies where feasible.
Method Development Tips
• Optimize mobile-phase ionic strength and pH for peak shape and response without compromising MS sensitivity.
• Evaluate SPE selectivity using anion-exchange sorbents to improve cleanup and sensitivity in complex matrices.
• Verify absence of in-source desulfation under chosen ionization conditions.
Documentation and Compliance
• Certificate of Analysis includes identity confirmation, purity, concentration (for solutions), uncertainty, and traceability.
• Batch-specific release data support accreditation and method validation requirements.
Packaging and Delivery
• Supplied as neat material or ready-to-use solutions in amber vials to protect from light.
• Temperature-controlled shipping options available to maintain integrity.
Analytical Standards (Reference Materials) — HPC Standards
• HPC Standards GmbH manufactures and distributes high-quality reference materials for thymol sulfate potassium salt for use in food, feed, biological, and environmental analysis.
• Product features: High purity, full documentation, and compatibility with LC–MS/MS workflows; optional custom concentrations and mixtures on request.
• Related offerings: Metabolites and isotope-labelled derivatives to support internal correction and comprehensive method validation.
Related Compounds
• Thymol (parent compound).
• Thymol glucuronide (complementary conjugate for metabolism studies).
• Isotope-labelled analogs for internal quantification, where available.