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Naphthylacetic acid (NAA) – Reference Materials for Residue and Quality Control
Naphthylacetic acid Precision Reference Materials for Confident Residue Analysis
Drive regulatory-ready results with HPC Standards high-purity Naphthylacetic acid 1-naphthaleneacetic acid, NAA reference materials. Engineered for HPLC-MSMS calibration and validation across complex food, feed, and environmental matrices, our traceable CRMs deliver outstanding accuracy, stability, and documentation. Choose from neat substances and ready-to-use solutions, with optional stable isotope-labelled derivatives for isotope-dilution workflows. Each batch ships with a detailed CoA and SDS, supporting method development, QC, and audit-readiness. Partner with HPC Standards for reliable NAA quantification and seamless compliance with international quality requirements.
Product | Catalog No./ CAS No. | Quantity | Price | |
|---|---|---|---|---|
ISO 17034 Reference Material |  | 673968 | 1X500MG | Please log in. |
1-Naphthylacetic acid solution |  | 685298 | 1X5ML | Please log in. |
ISO 17034 Certified Reference Material |  | 693032 | 1X250MG | Please log in. |
High-quality reference materials for the quantification of 1-naphthaleneacetic acid (NAA) in food, feed, and environmental matrices — manufactured and distributed by HPC Standards for regulatory-compliant residue analysis.
Overview
Naphthylacetic acid (NAA) is a synthetic auxin used as a plant growth regulator and rooting agent. Synonyms include 1-naphthaleneacetic acid, α-naphthaleneacetic acid, and NAA. Key identifiers: CAS 86-87-3; molecular formula C12H10O2; molar mass 186.21 g/mol; white solid; pKa ≈ 4.24; water solubility ≈ 0.42 g/L (20 °C). NAA is not naturally occurring and exhibits dose-dependent phytotoxicity at elevated concentrations.
In residue analysis and quality control, robust, traceable reference materials enable accurate calibration and validation for HPLC-MS/MS and related methods across complex matrices.
Uses
NAA is widely applied in horticulture and agriculture to stimulate rooting in cuttings, support micropropagation, and reduce premature fruit drop when applied post-bloom. Effective agronomic ranges are typically reported at 20–100 μg/mL depending on crop and application method. Excess concentrations can inhibit growth.
Representative applications include apples, olives, citrus, potatoes, and tissue culture systems.
Regulatory Status
United States: Products containing NAA are regulated as pesticides/plant growth regulators under FIFRA and require EPA registration and compliant labeling. Tolerances and use patterns are defined per crop and product registration.
European Union and other regions: NAA may be authorized as a plant growth regulator with substance-specific approvals and matrix-specific maximum residue limits (MRLs). Check current regional databases for active approvals, MRLs, and use restrictions.
Monitoring and Residue Control
Laboratories monitor NAA residues in plant-derived foods, beverages, and environmental samples to verify compliance with MRLs and good agricultural practices. Surveillance is often targeted post-application and pre-harvest, with selective testing at packhouse and import control points.
Matrix considerations: leafy vegetables, fruits, tubers, and processed products may require tailored extraction and cleanup (e.g., QuEChERS variants, acidified extraction) to achieve low LOQs and minimize matrix effects.
Analytical Methods
Primary technique: HPLC-MS/MS for selective, sensitive quantification of NAA in complex matrices. Typical workflows include acidified aqueous-organic extraction, dispersive cleanup, reversed-phase chromatography, and negative-ion ESI with MRM transitions. Method validation should address selectivity, linearity, recovery, matrix effects, precision, LOQ, and stability.
Confirmatory/orthogonal options may include LC-HRMS for elucidation of interferences and product ion confirmation. Method development should account for the weak acid character (pKa ~4.24) and limited water solubility.
Health Impact
Human toxicity: NAA is generally considered of low acute toxicity; oral LD50 values reported in rats range approximately 1000–5900 mg/kg. Risk management focuses on limiting exposure via residues and occupational handling. Safety assessments and ADI/ARfD values, where established, are defined by regional authorities.
Exposure routes for workers include dermal and inhalation during mixing/loading and application; appropriate PPE and engineering controls are required.
Environmental Impact
NAA undergoes oxidative processes in the environment, including reactions with hydroxyl and sulfate radicals, forming transient radical intermediates. Environmental persistence and mobility depend on pH, organic matter, and photolysis conditions. Proper stewardship reduces off-target exposure.
Effects on Wildlife
At elevated concentrations, auxin analogs can exhibit phytotoxicity to non-target plants. Risk to terrestrial and aquatic organisms is managed via label directions, buffer zones, and adherence to approved application rates.
Safety Measures
Handling: Use appropriate PPE (gloves, eye protection, lab coat) and work in well-ventilated areas or fume hoods. Avoid dust formation with solid forms. Follow SDS guidance for storage and first aid.
Storage: Store NAA and NAA reference materials in tightly closed containers, protected from light and moisture, at recommended temperatures. Avoid strong oxidizers and bases. Observe shelf-life and re-test dates.
Regulation and Compliance
Compliance requires verification against regional MRLs and approved use conditions. Laboratories should implement validated methods with ongoing quality control (system suitability, blanks, spikes, matrix-matched calibrations) and participate in proficiency testing where relevant.
Analytical Standards
HPC Standards provides certified reference materials for NAA to support calibration, system suitability, and method validation in residue testing. Materials are designed for traceability to international metrological standards, with detailed CoAs specifying purity, uncertainties, and storage conditions.
Available formats include neat materials and ready-to-use solutions at defined concentrations; stable isotope-labelled derivatives may be available upon request for isotope-dilution workflows and enhanced quantification accuracy.
Method Development Considerations
- Ionization: Negative ESI often preferred; optimize source conditions to minimize in-source fragmentation.
- Chromatography: Reversed-phase columns with acidic mobile phases can improve peak shape and retention; evaluate gradient profiles to separate matrix co-eluters.
- Sample prep: Consider pH control to maintain NAA in the non-ionized form during extraction; apply matrix-specific cleanup to reduce suppression.
Quality Assurance
Use multi-level calibration with matrix-matched standards or internal standards to correct matrix effects. Implement bracketing calibration and routine checks with independent QC levels. Document uncertainty budgets and maintain traceable reference materials for audit-readiness.
Matrices and LOQs
Typical target LOQs are governed by applicable MRLs and risk assessments. Fruits, vegetables, and plant tissues often require sub-μg/kg to low μg/kg ranges, depending on jurisdiction. Method sensitivity should be demonstrated in each relevant matrix.
Stability and Shipping
NAA is generally stable as a solid under dry, cool, and light-protected conditions. Solution stability depends on solvent composition, pH, and light exposure. HPC Standards ships reference materials with appropriate packaging and temperature control, accompanied by handling guidance and CoA.
Applications in R&D and QC
- Residue testing for regulatory compliance in food and feed
- Method validation and verification in accredited laboratories
- Plant physiology studies and formulation quality control
Ordering Information
HPC Standards offers NAA reference materials suitable for accredited laboratory use. Contact our technical support for product selection, custom concentrations, multi-analyte mixes, and stable isotope-labelled options. Batch-specific CoAs and SDS are provided with each delivery.