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Glycerol Reference Materials
Glycerol Precision Reference Materials for Confident Quantification
Elevate your QC with ISO-aligned glycerol standards from HPC Standards. Our high-purity neat materials and ready-to-use solutions deliver traceable values, low uncertainty, and proven lot-to-lot consistencyideal for food, pharmaceutical, environmental, and eliquid analysis. Access isotopically labeled options e.g., 13C3, d8 for matrixmatched calibration, supported by comprehensive CoAs, SDS, and SI traceability. Rely on rapid lead times, custom concentrations, and expert technical support to secure regulatory compliance and robust, reproducible results.
Product | Catalog No./ CAS No. | Quantity | Price | |
|---|---|---|---|---|
 | 676564 | 1X100MG | Please log in. | |
ISO 17034 Reference Material |  | 680278 | 1X1ML | Please log in. |
ISO 17034 Certified Reference Material |  | 693777 | 1X1ML | Please log in. |
Reliable reference materials for accurate quantification of glycerol across food, environmental, pharmaceutical, and e‑liquid matrices. ISO-compliant quality, comprehensive documentation, and lot-to-lot consistency from HPC Standards.
Overview
Glycerol (CAS 56-81-5) is a trihydric alcohol widely present in food, pharmaceuticals, cosmetics, industrial formulations, and e-liquids. It is a key analyte and matrix component in quality control and residue monitoring due to its technological functions (humectant, solvent, plasticizer) and relevance in process control. Accurate measurement requires traceable reference materials to ensure comparability and regulatory compliance.
Chemical Identity and Properties
Chemical name: Propane-1,2,3-triol; Synonyms: Glycerin, Glycerine. Molecular formula: C3H8O3; Molecular weight: 92.09 g/mol. Appearance: colorless, viscous liquid; Density ~1.26 g/cm³ (20 °C). Melting point ~17.8 °C; Boiling point ~290 °C (decomposes). Highly hygroscopic; miscible with water and alcohols. Low volatility; strong hydrogen bonding influences chromatographic behavior.
Uses and Applications
Food additive (E 422) as humectant and sweetener; excipient in pharmaceuticals; component in personal care products; cryoprotectant in laboratories; major solvent/base in e-liquids with propylene glycol; intermediate in chemical manufacturing and biodiesel by-product. Monitoring ensures product quality, process control, and labeling accuracy.
Regulatory Status
Recognized as GRAS in the US for specified uses; authorized as food additive E 422 in the EU with purity criteria defined in relevant monographs. Pharmacopoeial monographs exist in Ph. Eur./USP for glycerol and glycerol-containing dosage forms. Sector-specific guidance governs composition and impurities in e-liquids and inhalation products. Analytical verification supports compliance with labeling, purity, and contaminant limits.
Monitoring and Typical Matrices
Common matrices: beverages, confectionery, bakery, dairy analogs, syrups; e-liquids and aerosols; pharmaceutical syrups and topicals; fermentation broths; environmental samples impacted by industrial discharge. Typical tasks: quantification of glycerol, determination of PG/VG ratios, detection of residual solvents/impurities (e.g., diethylene glycol), and stability studies.
Health Impact
Glycerol exhibits low acute oral toxicity and is generally well tolerated in ingested products at authorized levels. Excessive intake may cause gastrointestinal discomfort due to osmotic effects. Inhalation of aerosols or thermal decomposition products can irritate the respiratory tract; thermal degradation can form acrolein under high heat conditions. Appropriate workplace controls and product specifications mitigate risk.
Environmental Impact
Glycerol is readily biodegradable, with low bioaccumulation potential and low aquatic toxicity at environmentally relevant concentrations. High localized releases may cause transient increases in biochemical oxygen demand (BOD), potentially affecting dissolved oxygen in receiving waters. Good manufacturing and waste management practices minimize environmental load.
Safety Measures and Handling
Handle with standard laboratory hygiene. Avoid aerosol formation and overheating to prevent thermal decomposition. Store in tightly closed containers to limit moisture uptake. In case of fire, note potential formation of acrolein; use appropriate firefighting measures. Consult the Safety Data Sheet for detailed guidance.
Storage and Stability
Store reference materials at 2–8 °C or as stated on the certificate. Protect from light and moisture ingress. Glycerol solutions are generally stable when stored in amber glass with minimal headspace; monitor for water uptake and concentration changes. Follow expiry and re-test intervals provided in the certificate.
Analytical Methods
HPLC with refractive index detection for high-level quantification in simple matrices; LC-MS/MS for complex matrices with enhanced selectivity; GC-FID/GC-MS after derivatization (e.g., silylation) for volatile analysis; IC with PAD for polyol profiling; qNMR for purity assessment and primary value assignment. Method selection depends on matrix, required LOQ, and co-eluting polyols.
Sample Preparation
Typical approaches include dilution in water or alcohols, matrix-matched calibration, and use of isotopically labeled internal standards (e.g., glycerol-d8 or 13C3-glycerol) to correct matrix effects. For fatty or complex matrices, cleanup steps (protein precipitation, liquid–liquid extraction, or SPE) may be applied. Verify linearity over wide concentration ranges (mg/L to g/L) and assess carryover due to viscosity.
Calibration and Quality Control
Use traceable reference materials to establish calibration curves with defined uncertainty. Apply bracketing standards, independent check standards, and system suitability tests (retention time, peak symmetry, response precision). Validate methods for specificity, linearity, accuracy, precision, LOD/LOQ, robustness, and measurement uncertainty in accordance with ISO/IEC 17025 and applicable guidance.
Analytical Standards
HPC Standards provides reference materials for glycerol, including neat materials and ready-to-use solutions at defined concentrations. Options include isotopically labeled glycerol for internal standardization. Each lot is accompanied by a comprehensive certificate of analysis detailing purity, concentration, uncertainty, traceability, and storage conditions.
Quality and Accreditation
Production follows international quality requirements. Testing and characterization align with ISO/IEC 17025 principles, and production of reference materials follows ISO 17034 guidelines. Homogeneity, stability, and value assignment are controlled to ensure fitness for purpose in regulatory testing.
Method Applications by Sector
Food: verification of additive levels (E 422), sweetness and texture optimization, and detection of non-permitted glycols. Pharmaceuticals: excipient assay, impurity profiling, and stability studies. E-liquids: PG/VG ratio confirmation and thermal decomposition studies. Environmental/industrial: process monitoring and discharge control.
Compliance and Documentation
Supplied documentation supports audits and accreditation: certificate of analysis, safety data sheet, batch traceability, and transport information. Reference values are traceable to SI where applicable, with stated expanded uncertainties and coverage factors.
Advantages of HPC Standards Reference Materials
High lot-to-lot consistency, tailored concentrations, short lead times, and technical support. Availability of custom blends, matrix-matched solutions, and isotope-labeled materials enables robust quantification and improved measurement reliability across diverse matrices.
Ordering Information
Reference materials are supplied in amber glass with tamper-evident closures. Standard pack sizes and concentrations are available; custom configurations on request. For quotations, batch availability, and technical datasheets, contact HPC Standards customer service.