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Ethylhexyl 4-methoxycinnamate (Octinoxate) – Reference Materials for Residue and Environmental Analysis
Ethylhexyl 4-methoxycinnamate Premium Reference Materials for Precise Residue and Environmental Analysis
Ensure confident identification, quantification, and compliance with HPC Standards high-purity Ethylhexyl 4-methoxycinnamate Octinoxate reference materials. Trusted by laboratories in environmental, cosmetic, and product safety testing, our materials come with comprehensive CoAs, ISO-aligned quality, and batch-specific data. Available as neat standards or ready-to-use solutions, with custom concentrations, multi-analyte mixes, and isotopically labelled options on request. Rely on our technical support for LCMSMS and HRMS workflows, matrix-matched calibration, and robust method validationso you meet regulatory limits with accuracy and efficiency.
Product | Catalog No./ CAS No. | Quantity | Price | |
|---|---|---|---|---|
 | 676225 | 1X100MG | Please log in. | |
2-Ethylhexyl 4-methoxycinnamate solution |  | 693490 | 1X5ML | Please log in. |
D3-2-Ethylhexyl 4-methoxycinnamate solution |  | 693378 | 1X1ML | Please log in. |
HPC Standards GmbH supplies high-quality reference materials for Ethylhexyl 4-methoxycinnamate to support accurate identification, quantification, and regulatory compliance in environmental, cosmetic, and product safety testing.
Overview
Ethylhexyl 4-methoxycinnamate (commonly known as Octinoxate; OMC) is an organic UV-B filter widely used in sunscreens and personal care products. It is frequently detected in wastewater, surface waters, sediments, and biota due to down-the-drain emissions and environmental persistence.
Targeted monitoring and validated quantification are essential for exposure assessment, product control, and compliance with cosmetic regulations and local environmental restrictions.
Chemical Identity
Synonyms: Octinoxate; 2-Ethylhexyl p-methoxycinnamate; Ethylhexyl 4-methoxycinnamate; OMC
CAS: 5466-77-3 | EC: 226-775-7
Molecular formula: C18H26O3 | Molecular weight: 290.40 g/mol
Physicochemical properties (typical): hydrophobic (log Kow high), low water solubility, strong UV absorption around 310–312 nm; low vapor pressure; prone to photodegradation under UV exposure.
Uses and Applications
- UV-B filter in sunscreens, skin-care, and cosmetic formulations
- UV absorber in certain plastics and coatings
- Analytical target/analyte in environmental and wastewater-based monitoring programs
Regulatory Landscape
- Cosmetics (EU): authorised UV filter with maximum concentration limits in finished products (e.g., up to 10% w/w in certain categories; consult current Annex VI of the EU Cosmetics Regulation for specific conditions).
- United States: sunscreen active under ongoing FDA evaluation; additional safety data requirements have been proposed; current market availability subject to evolving OTC sunscreen rulemaking.
- Regional environmental restrictions: several jurisdictions (e.g., certain U.S. states and island nations) restrict sale or use of products containing Octinoxate due to reef and aquatic ecosystem concerns. Always verify local rules.
Monitoring and Surveillance
- Matrices: wastewater influent/effluent, surface water, groundwater, sediments, sludge, biota (fish, invertebrates), and consumer products.
- Objectives: source tracking, treatment performance assessment, environmental risk assessment, product compliance, and human exposure studies (e.g., biomonitoring of metabolites).
- Frequency: routine in WWTP and receiving waters; targeted campaigns in recreational waters and sensitive ecosystems.
Analytical Methodology
- Primary techniques: LC–MS/MS (preferred for sensitivity and selectivity) and LC–HRMS for non-target screening and transformation product elucidation; GC–MS feasible following derivatization.
- Ionization and transitions: ESI+ commonly applied; monitor characteristic precursor/product ions; confirm with qualifier ratios and retention time matching to reference materials.
- Calibration: multi-level matrix-matched calibration with internal standardization (ideally isotopically labelled analog) for recovery and matrix effect correction.
Sample Preparation
- Water: solid-phase extraction (SPE; C18 or polymeric phases); elution with organic solvent; optional clean-up.
- Sediments/biota: solvent extraction (e.g., acetone/hexane or MeOH), clean-up via silica/Florisil or dSPE; lipid removal as needed.
- Cosmetics/products: dilution in suitable organic solvent; where required, QuEChERS-type extraction and filtration to reduce matrix effects.
Typical LOQs and Performance
- Water: sub-ng/L to low ng/L (LC–MS/MS) depending on SPE volume and instrument sensitivity.
- Sediment/biota: low µg/kg (wet or dry weight) with appropriate clean-up.
- Key validation parameters: linearity, precision, accuracy/recovery, matrix effects, MDL/LOQ, and stability (short- and long-term).
Quality and Traceability of Reference Materials
HPC Standards GmbH provides reference materials with comprehensive Certificates of Analysis (CoA), including identity confirmation, purity determination, uncertainty (for solutions), and storage recommendations. Materials are manufactured under rigorous quality systems to align with international analytical requirements.
Health Impact (Human Toxicity)
- Exposure routes: primarily dermal (cosmetic use), with limited systemic absorption; minor oral or inhalation exposure possible from environmental sources.
- Toxicity profile: low acute toxicity; potential endocrine activity under evaluation; rare cases of skin sensitization or irritation reported. Risk depends on dose, formulation, and exposure duration.
- Biomonitoring: parent compound and phase II conjugated metabolites (e.g., 4-methoxycinnamic acid derivatives) may be detectable in human samples following use.
Environmental Impact
- Fate: sorption to organic matter; persistence in sediments relative to water column; photolysis and biodegradation pathways yield transformation products.
- Occurrence: frequent detection in urban surface waters and WWTP effluents; seasonal peaks linked to recreational activities.
Effects on Wildlife and Aquatic Systems
- Aquatic toxicity: adverse effects reported in invertebrates and fish at elevated concentrations; chronic endpoints are of concern.
- Coral reef concern: implicated in coral and reef ecosystem stress in sensitive regions, motivating local restrictions.
Occupational Safety and Handling
- Handle in a fume hood; avoid skin and eye contact; use appropriate PPE (gloves, safety glasses, lab coat).
- Prevent light exposure during handling to minimize photodegradation; use amber glassware where feasible.
- Refer to the product Safety Data Sheet (SDS) for detailed hazard and precautionary statements.
Storage and Stability
- Store sealed in amber containers, cool and dry; minimize light and heat exposure.
- For solution reference materials, follow label instructions (e.g., temperature, solvent compatibility, shelf-life, and open-vial stability).
Calibration and Quantification Strategy
- Use bracketing calibration with at least 5–7 levels; incorporate procedural blanks and matrix spikes.
- Employ isotopically labelled internal standards where available to correct for recovery and ion suppression/enhancement.
- Verify identity with at least two MRM transitions (or exact mass/fragment match in HRMS) and retention time agreement with reference materials.
Interferences and Transformation Products
- Potential interferences from other UV filters and cosmetic ingredients; chromatographic resolution and MS selectivity are critical.
- Monitor relevant transformation products where risk assessments require (e.g., photolysis products and phase I/II metabolites) using HRMS libraries or in-house standards.
Compliance and Reporting
- Document method validation per ISO/IEC 17025 or equivalent laboratory quality standards.
- Report results with uncertainty, LOQ/LOD, recovery-corrected concentrations, and matrix descriptors (e.g., wet vs. dry weight).
Analytical Reference Materials
- Formats: neat solid and ready-to-use solutions in acetonitrile or methanol at defined concentrations; custom concentrations on request.
- Accompanying documentation: CoA, SDS, and batch-specific data (purity, uncertainty, expiration, storage).
- Related materials: metabolites or structurally related UV filters; isotopically labelled analogs for internal standardization where available.
Product and Ordering Information
- Packaging: amber glass vials/ampoules; multiple pack sizes for routine calibration and QC.
- Custom services: bespoke mixes (e.g., multi-UV filter calibration sets), stability studies, and method development support.
- Lead times and availability: contact HPC Standards GmbH for quotations, technical data, and regulatory support tailored to your application.