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Tributyl O-acetylcitrate (Acetyl tributyl citrate, ATBC)
Tributyl O-acetylcitrate High-Purity Reference Materials for Confident ATBC Compliance Testing
Ensure precise, reproducible quantification of ATBC across food-contact, environmental, and consumer product matrices with HPC Standards high-purity reference materials. Our ATBC standards neat and custom solution formats are manufactured and validated to international quality requirements, supplied with comprehensive CoA, uncertainty, and traceability. Benefit from robust identity and purity confirmation MS, NMR where applicable, homogeneitystability control, and optional isotope-labelled analogues for matrix-compensated calibration. Ideal for GC-MSLC-MS workflows, migration studies, method development, and routine monitoring aligned with EU 102011, FDA 21 CFR, and ISOIEC 17025 expectations. Partner with HPC Standards for reliable results and seamless regulatory confidence.
Product | Catalog No./ CAS No. | Quantity | Price | |
|---|---|---|---|---|
 | 693323 | 1X10MG | ||
D3-Tributyl O-Acetylcitrate solution |  | 693344 | 1X1ML | |
 | 677050 | 1X250MG | Please log in. | |
Tributyl O-acetylcitrate solution |  | 689773 | 1X5ML | Please log in. |
High-purity reference materials for precise quantification of ATBC in food-contact, environmental, and consumer product testing.
Overview
Tributyl O-acetylcitrate (ATBC) is a citrate ester widely used as a non-phthalate plasticizer in polymers such as PVC, cellulose derivatives, and various elastomers. It is valued for its good compatibility with plastics, low volatility, favorable toxicological profile compared to many phthalates, and suitability for food-contact and sensitive applications.
For laboratories, accurate determination of ATBC in materials and residues is essential to verify compliance with regulatory limits and to support product safety and quality assurance.
Synonyms & Identifiers
Synonyms: Acetyl tributyl citrate; Acetyl tri-n-butyl citrate; ATBC.
CAS: 77-90-7. EC (EINECS): 201-067-0. Molecular formula: C20H34O8. Approx. molar mass: ~402.5 g/mol.
Chemical class: Citrate ester plasticizer.
Uses
- Plasticizer for PVC and cellulose-based polymers in food-contact materials, films, coatings, and gaskets.
- Applications in medical devices, toys, and consumer goods as an alternative to regulated phthalates.
- Additive in inks, adhesives, sealants, and personal care formulations where low odor and low toxicity are required.
Chemical & Physical Properties
- Appearance: Colorless to pale oily liquid (neat substance).
- Low volatility, good plasticization efficiency, and good compatibility with polar polymers.
- Expected to be hydrolytically and thermally more stable under neutral conditions; sensitive to strong acids/bases (ester hydrolysis).
Regulatory
- European Union: Listed for specific uses in plastic food-contact materials (EU Framework and Plastics Regulation (EU) No 10/2011) with specific migration considerations. Users must consult the latest annexes and SML requirements for ATBC in their application.
- REACH (EU): Industrially used plasticizer; suppliers typically maintain registration and SDS. Downstream users should confirm current registration status.
- United States: Permitted in certain FDA food-contact applications; consult applicable 21 CFR listings for use conditions and limitations.
- Other regions: National regulations may define migration limits or permitted uses in food-contact and children’s products; verify local compliance.
Monitoring
Routine monitoring focuses on specific migration from finished articles into food simulants, residual content in polymers, and potential occurrence in environmental samples (e.g., wastewater, sediments) due to plasticizer leaching.
Quality control programs include incoming material verification, batch release testing, and compliance testing against SMLs or customer specifications.
Analytical Methods
- Sample preparation: Solvent extraction (e.g., acetonitrile, hexane, ethyl acetate) from polymer matrices; migration testing using standardized food simulants. Solid-phase extraction (SPE) or dispersive cleanup may be applied for complex matrices.
- Instrumentation: GC-MS or GC-MS/MS for volatile/semi-volatile determination; LC-MS/MS for thermally labile matrices or when co-elution is a concern. HPLC-UV may be used for screening with appropriate wavelength selection.
- Identification and quantification: External or internal standard calibration with isotopically labelled internal standards where available to correct for matrix effects and recovery.
Method Validation Parameters
Validation typically includes: selectivity, linearity, range, accuracy (recovery in relevant matrices), precision (intra-/inter-day), LOD/LOQ, matrix effects, robustness, and measurement uncertainty in line with ISO/IEC 17025 and SANTE/other sector guidance.
Health Impact
- Human toxicity: ATBC demonstrates low acute toxicity in animal studies and is generally considered to have a favorable toxicological profile relative to many phthalate plasticizers. It is not typically classified as CMR by major regulatory frameworks.
- Exposure routes: Primary exposure occurs via migration from food-contact materials, dermal contact from consumer products, and occupational handling. Good manufacturing and laboratory practices minimize exposure.
Environmental Impact
ATBC is reported to be readily biodegradable under standard test conditions, with low potential for bioaccumulation. Aquatic toxicity is generally low to moderate; nonetheless, releases to the environment should be minimized through proper waste management.
Effects on Wildlife
Given its biodegradability and lower bioaccumulation potential, widespread biomagnification is unlikely. Acute and chronic effects can occur at elevated concentrations; local risk assessments should consider site-specific exposure scenarios.
Safety Measures
- Handling: Use in well-ventilated areas. Avoid inhalation of aerosols/mists and prolonged skin contact. Employ PPE (lab coat, gloves, eye protection).
- Storage: Store tightly closed, protected from light and heat. Follow SDS guidance for temperature and compatibility. Keep away from strong acids/bases that catalyze hydrolysis.
- Spill and waste: Absorb with inert material and dispose according to local regulations. Prevent entry into waterways.
Compliance & Regulation Strategy
Implement a compliance plan covering supplier qualification, incoming material checks, periodic migration testing, documentation of intended use conditions, and traceability. Maintain current regulatory references (EU 10/2011, FDA 21 CFR, national regulations) for target markets.
Matrices & Application Areas for Testing
- Food-contact: PVC seals, cling films, gaskets, coatings, paper/board with plastic layers.
- Environmental: Wastewater, sludge, sediments near plastic processing sites.
- Consumer and medical: Toys, medical tubings, coatings, personal care matrices.
Analytical Standards
HPC Standards provides high-purity reference materials for Tributyl O-acetylcitrate to support accurate quantification in compliance testing, method development, and routine monitoring. Products are accompanied by comprehensive documentation (CoA with purity, uncertainty, and traceability).
Available formats include neat materials and calibrated solutions (on request), with options for matrix-matched solutions and stable isotope-labelled analogues for internal standardization where applicable.
Quality & Certification
Our reference materials are manufactured and tested according to international quality requirements. Each lot undergoes stringent identity confirmation (MS, NMR where applicable), purity assessment, and homogeneity/stability checks, ensuring reliable results across accredited laboratories.
Stability & Storage of Reference Materials
Store reference materials as indicated on the label/CoA. Typical recommendations: 2–8 °C for solutions, ambient to 25 °C for sealed neat materials, protected from light. Observe shelf life and requalification intervals. Allow solutions to reach room temperature before opening to minimize condensation.
Ordering Information
- Analyte: Tributyl O-acetylcitrate (ATBC, CAS 77-90-7)
- Formats: Neat material; solution standards at custom concentrations/solvents upon request.
- Documentation: CoA, Safety Data Sheet, and method support on request. Batch-specific information provided for traceability.
Related Compounds
Complementary reference materials: Tributyl citrate (TBC, CAS 77-94-1), Triethyl citrate (TEC), Acetyl triethyl citrate (ATEC), and selected phthalate alternatives to support comprehensive plasticizer screening.