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Fumonisin B2 – Reference Materials for Residue Analysis
Fumonisin B2 Precision Reference Materials for Confident Compliance
Ensure rock-solid quantification of Fumonisin B2 FB2 in food, feed, and environmental matrices with validated reference materials from HPC Standards GmbH. Our high-purity FB2available as neat and ready-to-use solutions, plus custom FB1FB2FB3 mixesdelivers traceability for calibration, method validation, and routine QC in LC-MSMS or LC-FLD workflows. Each lot ships with a comprehensive CoA identity, purity, concentration, uncertainty, storage, expiry and meets international quality requirements to support ISOIEC 17025 accreditation. Rely on lot-to-lot consistency, global availability, and expert technical support to streamline compliance monitoring and accelerate secure decision-making across your supply chain.
Product | Catalog No./ CAS No. | Quantity | Price | |
|---|---|---|---|---|
 | 680212 | 1X5MG | Please log in. | |
ISO 17034 Certified Reference Material Fumonisin B2 solution |  | 682049 | 1X1ML | Please log in. |
ISO 17034 Certified Reference Material Fumonisin B2 solution |  | 682050 | 1X5ML | Please log in. |
High-quality reference materials for Fumonisin B2 (FB2) to support accurate quantification in food, feed, and environmental matrices. Manufactured and tested to international quality requirements for reliable compliance monitoring.
Overview
Fumonisin B2 (FB2) is a mycotoxin of the fumonisin family produced primarily by Fusarium species that contaminate maize and related cereals. FB2 commonly co-occurs with fumonisin B1 (FB1) and B3 (FB3). Due to its toxicological relevance and frequent detection in maize supply chains, FB2 is closely monitored in food and feed safety programs worldwide.
HPC Standards GmbH provides validated reference materials for Fumonisin B2 to ensure traceable quantification, robust method validation, and ongoing quality control in accredited laboratories.
Chemical Identity
Class: Fumonisin (aminopolyol backbone esterified with tricarboxylic acids). FB2 is a structural analogue of FB1 with similar physicochemical behavior in chromatographic systems.
Properties: Polar, non-volatile, thermally labile; well suited to LC-based detection (LC-FLD with derivatization or LC-MS/MS). High affinity for aqueous-organic extraction (e.g., methanol–water).
Sources and Occurrence
Primary producers: Fusarium verticillioides and Fusarium proliferatum associated with maize and maize-based products. Occurrence is influenced by crop stress, climate, storage conditions, and geographic region.
Matrices: Unprocessed maize, maize grits, flours, breakfast cereals, snack foods, feed, and by-products. Co-contamination with other Fusarium toxins is common.
Uses
FB2 has no intentional industrial or food use. It is a contaminant of concern in food and feed safety management and is addressed via preventive agricultural practices and analytical monitoring.
Regulatory Landscape
Global regulations typically set maximum levels for the sum of fumonisins (commonly FB1 + FB2, sometimes including FB3) in maize and maize-derived foods and feeds. Limits vary by jurisdiction and matrix (e.g., unprocessed maize, processed maize foods, and foods for infants/young children).
Risk assessment bodies have established group health-based guidance values for fumonisins, applying to the combined exposure to principal B-series fumonisins. Laboratories should verify current legal limits and guidance values applicable to their markets.
Monitoring and Surveillance
Routine monitoring programs target high-risk raw materials (maize and derivatives), finished products, and feed. Sampling plans should address lot size, heterogeneity, and co-occurrence with FB1 and FB3.
Trend analysis across harvest years, suppliers, and regions supports preventive controls and supplier qualification. Reference materials are essential for inter-batch comparability and proficiency testing.
Health Impact
FB2 disrupts sphingolipid metabolism via inhibition of ceramide synthase, leading to altered sphinganine/sphingosine ratios—a mechanistic biomarker frequently used in research. Toxicological concerns include liver and kidney effects in animal studies, with overall risk management typically applied to the sum of fumonisins.
Human Toxicity
Potential health risks are linked to dietary exposure through contaminated maize products. Risk assessments apply margin-of-exposure approaches or group tolerable intakes to combined fumonisin exposure. Sensitive populations include infants and young children, for whom stricter limits may apply.
Environmental Impact
FB2 occurrence is tied to crop infection in the field and during storage. While fumonisins are not persistent environmental pollutants in the conventional sense, poor storage conditions can promote fungal growth and toxin formation, affecting food security and feed safety.
Effects on Wildlife
Exposure in livestock and wildlife can occur via contaminated feed or residues in agricultural settings. Effects parallel mammalian toxicity endpoints observed in controlled studies, emphasizing the importance of mycotoxin control in feed chains.
Safety Measures
Industrial hygiene: Implement dust control when handling contaminated grain. Use PPE during sampling, extraction, and analysis. Follow chemical safety protocols for solvents and reagents.
Preventive controls: Good agricultural and storage practices (drying, moisture control, temperature management), supplier verification, and regular analytical screening reduce fumonisin risk.
Analytical Methods
Primary techniques: LC-MS/MS (multi-mycotoxin methods) for high selectivity and sensitivity; LC-FLD following pre-column derivatization (e.g., OPA) as an alternative. Quantification typically targets individual fumonisins with reporting of sums per regulation.
Sample preparation: Extraction with aqueous-organic solvents (e.g., methanol–water), optional clean-up via SPE or immunoaffinity. Matrix-matched calibration or isotope dilution is recommended to address matrix effects.
Quality Control and Calibration
Use of traceable reference materials for FB2 is critical for calibration curve preparation, recovery assessment, method validation (LOD/LOQ, linearity, precision, trueness), and routine QC (control charts, system suitability).
Inclusion of internal standards (stable isotope-labelled analogues, where applicable) improves accuracy and compensates for matrix suppression/enhancement in LC-MS/MS.
HPC Standards Reference Materials
Product formats: Neat FB2 and solution-based reference materials in defined concentrations suitable for calibration and quality control. Custom concentrations and mixture compositions (e.g., FB1/FB2/FB3 mixes) available on request.
Related offerings: Reference materials for major mycotoxins (e.g., FB1, FB3, aflatoxins, DON, ZEN, T-2/HT-2) and, where available, stable isotope-labelled derivatives for isotope dilution workflows.
Specifications and Documentation
Each lot is supplied with a Certificate of Analysis detailing identity confirmation, purity, concentration (for solutions), uncertainty, storage conditions, and expiry. Characterization follows international quality requirements to support method accreditation.
Lot-to-lot consistency and traceability enable reliable long-term monitoring and interlaboratory comparability.
Storage and Stability
Store reference materials according to the CoA (typically refrigerated or frozen, protected from light and moisture). Allow to equilibrate before opening; minimize freeze–thaw cycles. Observe shelf-life and re-test dates.
Method Development Support
Reference materials facilitate optimization of extraction efficiency, evaluation of matrix effects, selection of chromatographic conditions, and confirmation of analyte identity via ion ratios and retention times.
Matrix-matched and spiking solutions are available to streamline validation in target commodities (maize, flours, feeds, and derived products).
Compliance and Accreditation
Our reference materials support ISO/IEC 17025 workflows and align with regulatory requirements for fumonisin monitoring. Comprehensive documentation supports audits and compliance reporting across global markets.
Logistics and Availability
Global shipping with temperature-appropriate packaging where required. Hazard and transport classifications are provided as applicable. Technical support is available for selection, handling, and method-related inquiries.
Applications
- Regulatory monitoring of maize and maize-based foods
- Supplier qualification and incoming goods control
- Feed safety programs and HACCP verification
- Method validation, proficiency testing, and routine QC in LC-MS/MS and LC-FLD
Contact and Custom Solutions
For tailored mixtures (e.g., combined FB1/FB2/FB3), bespoke concentrations, or stable isotope-labelled reference materials, contact HPC Standards GmbH. We partner with laboratories in food and environmental analysis to ensure robust, compliant results.