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Sulfabenzamide Reference Materials
Sulfabenzamide Precision Reference Materials for Confident Residue Analysis
Elevate your pharmaceutical and environmental workflows with high-purity Sulfabenzamide reference materials from HPC Standards. Our certified neat and solution standards enable accurate calibration, system suitability, and traceable QC across HPLCLCMSMS methods. Each lot is comprehensively characterized HPLC, NMR, MS and delivered with a CoA, uncertainty, and storage guidance to meet international quality requirements.
- Ready-to-use solutions and custom concentrations for method linearity ngmL to mgmL
- Options for multi-residue panels and isotopically labeled analogs when available
- Proven performance in pharmaceutical QC, legacy product surveillance, and wastewater monitoring
- Reliable support for validation aligned with ICH, USPPh. Eur., and ISOIEC 17025
Choose HPC Standards as your partner for consistent, audit-ready results in antimicrobial residue analysis. Contact us for current inventory and CoAs.
Product | Catalog No./ CAS No. | Quantity | Price | |
|---|---|---|---|---|
 | 693547 | 1X5MG | ||
D4-Sulfabenzamide solution |  | 693548 | 1X1ML | |
 | 675455 | 1X250MG | Please log in. | |
Sulfabenzamide solution |  | 679805 | 1X1ML | Please log in. |
Reliable reference materials for precise qualitative and quantitative determination of sulfabenzamide in pharmaceutical, veterinary, and environmental matrices. Produced and tested to international quality requirements for confident compliance and method validation.
Overview
Sulfabenzamide (CAS 127-71-9) is a sulfonamide-class antibacterial compound historically used topically, including in combination with sulfathiazole and sulfacetamide in intravaginal formulations. It remains relevant for analytical laboratories in the context of pharmaceutical quality control, legacy product surveillance, and environmental monitoring of antimicrobial residues.
HPC Standards provides high-purity reference materials of sulfabenzamide to support accurate calibration, system suitability, and quality assurance in chromatographic and mass-spectrometric workflows.
Chemical Identity
IUPAC name: 4-Amino-N-benzoyl-benzenesulfonamide
Molecular formula: C13H12N2O3S
Molar mass: 276.31 g/mol
Key identifiers: CAS 127-71-9; ChemSpider 5128; UNII G58F8OPL4I; ChEMBL ChEMBL1243; EPA CompTox DTXSID7045287
Structural features: an anilide linked to a benzenesulfonamide bearing a para-amino group (typical of sulfonamide antibacterials).
Applications and Uses
- Historical use as a topical antibacterial, often in combination preparations (e.g., with sulfathiazole and sulfacetamide).
- Current analytical relevance in pharmaceutical raw-material and finished-product testing (legacy formulations), impurity profiling, and stability studies.
- Environmental and wastewater surveillance as part of antimicrobial residue monitoring programs.
Regulatory Status
- Not widely used as a modern systemic therapeutic; primarily of historical and niche topical importance. Market authorization status varies by jurisdiction.
- Laboratories may encounter sulfabenzamide in legacy products, compounded preparations, or as part of environmental occurrence studies. Always consult local and regional regulations for applicable limits and reporting requirements.
Monitoring and Residue Analysis
- Target analyte in pharmaceutical QC (identity, assay, related substances) and in environmental monitoring of antimicrobials in influent/effluent, surface waters, sludge, and sediments.
- Typical matrices: raw materials (APIs), finished products, wastewater, surface water, groundwater, sludge, sediments, and biota extracts.
- Method performance characteristics to establish: selectivity, linearity, recovery, precision, LOQ/LLOD, matrix effects, and stability.
Analytical Methods
- Chromatography: HPLC-UV/PDAD or LC-MS/MS for higher selectivity and sensitivity; UHPLC recommended for throughput and peak shape.
- Sample preparation: SPE (reversed-phase, mixed-mode) or LLE depending on matrix; protein precipitation for biological extracts; filtration and pH control to reduce matrix interferences.
- Ionization/fragmentation: ESI (negative or positive mode depending on method design) commonly applied for MS detection; monitor characteristic sulfonamide fragments for confirmatory analysis.
Reference Materials from HPC Standards
- Product type: neat solid and solution reference materials with certified purity for calibration and system suitability.
- Purity: high-purity material with comprehensive characterization (e.g., HPLC, NMR, MS, water/volatile content, inorganic residues as applicable).
- Documentation: Certificate of Analysis (CoA) including traceability, assigned purity value with uncertainty, storage conditions, and intended use.
- Options: ready-to-use solutions at defined concentrations; custom mixtures on request; isotopically labeled analogs when available for internal standardization.
Matrices and Method Validation
- Calibration: external calibration with bracketed standards or isotope-dilution where available to correct matrix effects.
- Recovery studies: spike-and-recover at multiple levels across matrices (waters, sludge, pharmaceutical excipients) to establish accuracy.
- System suitability: retention time windows, resolution from structural analogs, peak symmetry, and signal-to-noise criteria defined using reference materials.
Storage and Stability
- Recommended storage: cool, dry, protected from light. Observe CoA-specific temperature guidance.
- Stability: assess short-term (bench-top), autosampler, freeze–thaw, and long-term stability in working solutions; re-prepare solutions according to validated hold times.
Quality and Documentation
- Manufactured and tested under international quality requirements to meet the highest industrial standards.
- Each lot supplied with CoA, safety documentation, and traceability information suitable for audits and regulatory submissions.
Health Impact
- Human toxicity: Sulfonamides can cause hypersensitivity reactions in susceptible individuals. Exposure routes in laboratories are primarily dermal and inhalation of particulates or aerosols.
- Risk management: minimize exposure by using closed handling, appropriate PPE, and validated decontamination procedures.
Environmental Impact
- Antimicrobial residues may contribute to selection pressure for resistant microorganisms in aquatic environments.
- Persistence and mobility depend on local conditions; include sulfabenzamide in screening programs where antimicrobial loads are assessed.
Effects on Wildlife
- Potential indirect effects through microbiome disruption in aquatic systems; direct ecotoxicity data may be limited. Monitoring programs should incorporate trend analysis in biota and sediments where relevant.
Occupational Safety Measures
- Engineering controls: fume hood or ventilated enclosure for weighing and solution preparation.
- PPE: lab coat, safety glasses, nitrile gloves; respiratory protection if dust or aerosols may form.
- Hygiene: avoid skin contact; wash after handling; prevent cross-contamination of benches and instruments.
Packaging and Logistics
- Packaging: inert, airtight containers to protect from moisture and light; tamper-evident seals.
- Shipping: temperature-controlled options available upon request. Products labeled with lot number, concentration (if solution), and expiry date.
Specifications and Customization
- Concentration ranges for solutions tailored to method linearity requirements (e.g., ng/mL to mg/mL).
- Custom mixes with related sulfonamides or multi-residue panels for screening methods.
- Matrix-matched solutions available on request to support verification and proficiency testing.
Regulatory and Compliance Support
- Support for method development and validation aligned with ICH, USP/Ph. Eur., and ISO/IEC 17025 principles.
- Lot-to-lot continuity and comprehensive metadata to facilitate data integrity and audit readiness.
Related Compounds
- Structural analogs: sulfacetamide, sulfathiazole, and other sulfonamide antibacterials can be supplied as complementary reference materials for specificity and interference studies.
Analytical Standards Availability
- HPC Standards supplies sulfabenzamide as reference materials for calibration, QC, and proficiency testing support. Contact us for current inventory, CoAs, and custom solution services.