New user? / Forgot your password?
0 Item | 0,00 €
Lactofen Reference Materials for Residue Analysis
Lactofen Reference Materials PRECISE, COMPLIANT, READY FOR LCGC WORKFLOWS
Power your residue analysis with high-purity Lactofen standards from HPC Standards GmbH. Manufactured and validated to international quality requirements, our traceable reference materials come with full CoA, SDS, and stability dataideal for method development, calibration, QC, and proficiency testing in LC-MSMS and GC-MS. Support ISOIEC 17025 and ISO 17034 workflows, achieve low-gkg LOQs in food and environmental matrices, and strengthen uncertainty estimates with optional isotope-labeled analogs. Reliable supply, custom concentrations, and expert supportso your results meet regulatory limits with confidence.
Product | Catalog No./ CAS No. | Quantity | Price | |
|---|---|---|---|---|
 | 674480 | 1X100MG | Please log in. | |
ISO 17034 Certified Reference Material Lactofen solution |  | 691542 | 1X5ML | Please log in. |
High-precision reference materials for Lactofen and related compounds to support compliant food and environmental residue testing, validated to international quality requirements and delivered with full documentation.
Overview
Lactofen is a diphenyl ether herbicide that inhibits protoporphyrinogen oxidase (PPO), disrupting chlorophyll synthesis and causing membrane peroxidation in susceptible broadleaf weeds. It is primarily used in post-emergence applications. For laboratories, accurate quantification of Lactofen and its transformation products is essential to verify regulatory compliance in food and environmental matrices.
HPC Standards GmbH provides Lactofen reference materials designed for method development, calibration, quality control, and proficiency testing in LC-MS/MS and GC-MS workflows.
Uses
Lactofen is applied post-emergence for control of broadleaf weeds in crops such as soybean, peanut, and cotton, and in certain non-crop settings. It is often integrated in resistance-management programs as a PPO inhibitor, complementing other herbicide modes of action.
Due to its contact activity and limited systemic translocation, application timing and coverage are critical for field efficacy, which in turn influences residue occurrence in harvest commodities and run-off.
Regulatory Landscape
Residue limits for Lactofen are established under multiple frameworks (e.g., EU MRLs under Regulation (EC) No 396/2005, US EPA tolerances under FIFRA/FFDCA, and Codex MRLs where applicable). Compliance requires validated analytical methods and traceable reference materials.
Registration, approval status, and MRLs vary by country and crop; laboratories should consult current national databases and commodity-specific regulations prior to reporting.
Monitoring & Surveillance
Routine surveillance targets Lactofen in plant-derived foods (oilseeds, pulses, leafy vegetables), processed products, surface and ground waters, sediments, and agricultural soils. Sampling plans often align with risk-based monitoring and seasonal application windows.
Quality assurance requires matrix-matched calibration, system suitability checks, and participation in proficiency testing using fit-for-purpose reference materials.
Analytical Methods
- Preferred detection: LC-MS/MS using ESI in negative or positive mode depending on method optimization; GC-MS may be used following derivatization when applicable.
- Sample prep: QuEChERS-type extraction and dispersive cleanup (PSA/C18/GCB as needed), or SPE for water; method conditions optimized to limit matrix effects and achieve low-µg/kg LOQs.
- Confirmation: Two transitions or HRMS accurate-mass confirmation; retention time matching with authentic reference materials.
Physicochemical Properties (Method-Relevant)
Lactofen is a weakly acidic diphenyl ether herbicide with very low vapor pressure, low water solubility, and high affinity to organic matter. It is readily soluble in common organic solvents (e.g., acetonitrile, methanol) used for calibration and spiking. These properties inform extraction efficiency, cleanup choices, and potential sorption losses during sample handling.
Metabolism and Degradation
In plants and the environment, Lactofen can undergo hydrolysis and biotransformation, forming diphenyl ether derivatives; analyses often include relevant transformation products for comprehensive residue definitions.
Photolysis and microbial pathways contribute to dissipation in surface matrices, while soil binding can reduce mobility but may prolong detectability in sediments.
Health Impact
- Human toxicity: Lactofen exhibits low to moderate acute oral and dermal toxicity with potential for eye and skin irritation. It is not highly volatile; primary exposure routes for workers are dermal and inhalation of aerosols during application or laboratory handling.
- Risk assessment considers dietary exposure against MRLs/tolerances and operator exposure under labeled use conditions; laboratories support these assessments with robust quantification and uncertainty estimation.
Environmental Impact
- Aquatic and terrestrial effects: As a PPO inhibitor herbicide, Lactofen may be toxic to aquatic plants and invertebrates at elevated concentrations. Soil binding can limit leaching, but runoff events may transport residues to surface waters.
- Effects on wildlife: Potential sublethal effects on non-target plants and primary producers can impact food webs; careful monitoring of water bodies and drift-prone habitats is recommended where use is prevalent.
Safety Measures (Laboratory)
- Handle Lactofen reference materials in a fume hood with appropriate PPE: lab coat, nitrile gloves, and eye protection.
- Avoid skin/eye contact and inhalation of aerosols; prevent ignition sources near organic solvent preparations; dispose of waste according to local hazardous waste regulations.
Compliance and Accreditation
HPC Standards GmbH supplies reference materials produced and tested according to international quality requirements, accompanied by Certificates of Analysis (CoA), Safety Data Sheets (SDS), and traceability information to support ISO/IEC 17025 and ISO 17034-compliant workflows.
Lot-specific purity, concentration, uncertainty, and stability data are provided to underpin method validation, calibration, and ongoing QC.
Matrix Applications
- Food: oilseeds, pulses, leafy vegetables, and processed matrices (oils, flours). Employ matrix-matched standards and internal standards where applicable.
- Environment: surface/ground water, soil, and sediment. Use appropriate preconcentration (e.g., SPE) and cleanup to achieve sub-µg/L or low-µg/kg detection limits.
Stability and Storage
Store Lactofen reference materials in tightly closed amber ampoules at 2–8°C, protected from light and moisture. Use high-purity solvents (acetonitrile or methanol) and verify stability-indicating parameters per CoA. Minimize freeze–thaw cycles and use aliquots for routine work.
Related Compounds and Metabolites
Laboratories may also monitor structurally related diphenyl ether herbicides and transformation products to satisfy residue definitions and risk assessments. HPC Standards can support multi-analyte panels on request.
Isotope-Labeled Reference Materials
Where available, isotope-labeled reference materials enable accurate internal standardization, improving recoveries, compensating for matrix effects, and enhancing measurement uncertainty estimates.
Documentation and Shipping
Each shipment includes CoA, SDS, and handling instructions. Products are packaged for temperature control and light protection to maintain integrity during transit. Custom concentrations, solvent systems, and combo kits are available upon request.
Analytical Performance Considerations
- Calibration: Prepare multi-level calibrations bracketing expected concentrations; verify linearity and back-calculation within acceptance criteria.
- QC: Include continuing calibration verification, laboratory control samples, matrix spikes/duplicates, and blanks. Track recoveries and measurement uncertainty in accordance with internal QA plans.
Why HPC Standards
As a manufacturer and distributor specialized in pesticides, veterinary compounds, metabolites, and stable isotope-labeled derivatives, HPC Standards GmbH is a reliable partner for laboratories conducting food and environmental analyses. Our Lactofen reference materials support precise, reproducible, and compliant residue determinations across complex matrices.