Flurbiprofen — Reference Materials for Residue and Environmental Analysis
Flurbiprofen — Precision Reference Materials for Confident Compliance
Ensure data integrity from pharma QC to environmental monitoring with HPC Standards’ high-purity Flurbiprofen reference materials. Available as neat solids and certified ready-to-use solutions, our standards support robust LC–MS/MS and HPLC-UV calibration, method validation, and QA/QC at trace levels. Each batch comes with a comprehensive CoA and SDS, with isotope‑labelled options and custom concentrations for matrix-matched workflows. Manufactured and tested under stringent international quality systems, HPC Standards is your reliable partner for accurate, reproducible results across laboratories and long-term monitoring programs.
Product | Catalog No./ CAS No. | Quantity | Price | |
|---|---|---|---|---|
ISO 17034 Reference Material |  | 692744 | 1X10MG | |
ISO 17034 Certified Reference Material D3-Flurbiprofen solution |  | 692745 | 1X1ML | |
ISO 17034 Reference Material |  | 680660 | 1X500MG | Please log in. |
HPC Standards provides high-quality reference materials for Flurbiprofen to enable precise quantification in pharmaceutical quality control and environmental monitoring. Our products support regulatory compliance and robust method validation in professional laboratories.
Overview
Flurbiprofen is a phenylalkanoic acid nonsteroidal anti-inflammatory drug (NSAID) used in human medicine (oral and ophthalmic). In analytics, it is a priority target for pharmaceutical residue monitoring in wastewater, surface water, and occasionally drinking water studies.
Due to high protein binding and hepatic metabolism (CYP2C9), it appears in environmental matrices mainly as parent compound and phase I/II metabolites at trace levels.
Chemical Identity
IUPAC: (RS)-2-(2-fluorobiphenyl-4-yl)propanoic acid
CAS: 5104-49-4 | Molecular formula: C15H13FO2 | Molar mass: 244.26 g/mol
Chirality: Racemic mixture | Melting point: ~117 °C
Applications and Uses
Therapeutic: oral analgesic/anti-inflammatory; ophthalmic anti-miotic (pre-operative). Analytical: target/analyte in pharmaceutical QC (ID, purity, assay, stability) and environmental occurrence studies (WWTP influent/effluent, surface waters, sediments).
Regulatory Landscape
Human medicinal product approvals exist in multiple jurisdictions (e.g., EMA/FDA country equivalents). For environmental monitoring, there are no globally harmonized limits specific to Flurbiprofen; however, pharmaceuticals are widely included in regional monitoring programs and risk assessments.
General NSAID class labeling: authorities recommend avoiding NSAIDs from 20 weeks of pregnancy due to risk of fetal renal effects and low amniotic fluid; applicable to Flurbiprofen-containing medicinal products.
Occurrence in the Environment
Primary sources: human therapeutic use with excretion to municipal wastewater; incomplete removal in treatment plants can lead to trace occurrence in receiving waters.
Typical concentration range: low ng/L to µg/L depending on region, season, and treatment efficacy (site-specific).
Monitoring and Target Matrices
Recommended matrices: pharmaceutical products (API/formulations), wastewater (influent/effluent), surface water, groundwater/drinking water (select programs), sludge/sediment (exploratory), and laboratory proficiency test samples.
Purpose: method development/validation, routine surveillance, trend analysis, and QA/QC (system suitability, calibration, recovery studies).
Sample Preparation
Water: solid-phase extraction (SPE; mixed-mode or hydrophilic–lipophilic balance) with acidified loading; elution with organic solvent and evaporation/reconstitution.
Complex matrices (sludge/sediment): solvent extraction (e.g., MeOH or MeOH:water), clean-up via SPE or dispersive techniques.
Pharmaceuticals: direct dilution for assay/purity; stability-indicating workflows for degradation studies.
Analytical Methods
LC–MS/MS: preferred for sensitivity and selectivity; negative ESI often suitable for acidic NSAIDs; MRM of deprotonated molecular ion and characteristic fragments.
HPLC–UV/DAD: applicable for higher concentrations (QC contexts) with wavelengths in the UV range; stability-indicating methods recommended.
Calibration: multi-level external calibration with matrix-matched standards; use of isotope-labelled internal standards where available to correct matrix effects and recovery.
Reporting Levels and QA/QC
Typical LOQs: low ng/L in waters by LC–MS/MS (method- and instrument-dependent). Ensure method blanks, spike recoveries (80–120% target), and duplicate precision (RSD <15%) meet internal criteria.
Traceability: use reference materials with documented purity, identity, and uncertainty. Include calibration verification standards and independent QC levels.
Health Impact — Human Toxicity
Class-consistent NSAID risks: gastrointestinal irritation/bleeding, renal effects, and potential cardiovascular concerns at therapeutic misuse or overdose.
Pregnancy: health authorities advise avoiding NSAIDs at ≥20 weeks of gestation due to fetal renal risk and oligohydramnios; clinical labeling applies to drug products, not laboratory reference materials.
Environmental Impact — Effects on Wildlife
Potential for adverse effects on aquatic organisms at elevated concentrations typical for NSAIDs; site-specific risk assessment advised. Biodegradation and photolysis may reduce persistence; removal in WWTPs varies with process design.
Safety Measures and Handling
For laboratory use only; not for human or veterinary administration. Avoid inhalation, ingestion, and skin/eye contact. Use PPE (lab coat, gloves, eye protection) and handle in a fume hood when preparing solutions.
Consult SDS for hazard information and first-aid measures. Dispose of waste according to local regulations for pharmaceutical chemicals.
Storage and Stability
Store neat materials and solutions tightly closed, in a cool, dry place, protected from light. Common solvents: acetonitrile or methanol. Follow labelled expiry and requalification intervals; monitor for degradation in stability studies (e.g., hydrolysis/oxidation).
Analytical Reference Materials
HPC Standards offers Flurbiprofen reference materials for calibration, system suitability, and quality control. Product formats include neat solids and ready-to-use certified solutions at defined concentrations with batch-specific CoA.
Isotope-labelled derivatives and custom concentrations/solvent systems are available on request to support isotope-dilution workflows and matrix-matched calibration.
Documentation and Compliance
Each product is supplied with a comprehensive Certificate of Analysis (purity, identity, uncertainty, traceability), Safety Data Sheet, and labeling compliant with international quality requirements.
Materials are produced and tested under stringent quality systems to meet the highest industrial standards for analytical applications.
Custom Services and Support
We provide custom mixture preparation (multi-analyte), stability studies, method transfer support, and re-order harmonization across sites to ensure consistency in long-term monitoring programs.
Technical support assists with method development (SPE selection, LC–MS/MS transitions, QC design) and documentation for audits.