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Propanol Reference Materials
Propanol Reference Materials PRECISION for VOC and Residual Solvent Testing
Unlock confident quantification with high-purity propanol standards from HPC Standards GmbH. Our 1-propanol and 2-propanol reference materialsavailable as neat substances and certified ready-to-use solutionsdeliver traceable accuracy for headspace GCGC-MS, purge-and-trap, and thermal desorption workflows across pharmaceuticals, food, environmental, and industrial applications. Built for ISO 1702517034-compliant QAQC, each lot includes full CoA, uncertainty data, and optional isotope-labelled internal standards to secure linearity, recovery, and method robustness. Rely on fast delivery, custom concentrations, and matrix-matched solutions to meet global regulatory limits with efficiency.
Product | Catalog No./ CAS No. | Quantity | Price | |
|---|---|---|---|---|
 | 678321 | 1X5ML | Please log in. | |
 | 678322 | 1X5ML | Please log in. | |
 | 693677 | 1X100MG | ||
 | 693678 | 1X100MG | Please log in. |
High-precision propanol reference materials for VOC and residual solvent analysis in pharmaceutical, food, environmental, and industrial laboratories.
Overview
Propanol refers to the C3 primary alcohols commonly encountered as 1-propanol (n-propanol) and 2-propanol (isopropanol). Both are volatile organic compounds (VOCs), miscible with water and many organic solvents, and widely used as solvents, process auxiliaries, and analytical reagents. In quality control and compliance testing, propanol is monitored as a residual solvent, workplace air contaminant, and environmental VOC.
HPC Standards GmbH provides propanol reference materials designed for robust quantification and method validation across diverse matrices, enabling reliable routine monitoring and regulatory compliance.
Chemical Identity and Isomers
1-Propanol (n-propanol): primary alcohol, CAS 71-23-8. Typical analyte for residual solvent and VOC methods; oxidized in vivo to propionaldehyde and propionic acid.
2-Propanol (isopropanol): secondary alcohol, CAS 67-63-0. Widely used disinfectant and solvent; metabolized primarily to acetone. Analytical separation of isomers is essential due to differing physicochemical behavior and toxicokinetics.
Applications and Uses
— Solvent and processing aid in pharmaceutical synthesis and formulation (residual solvent control).
— Extraction solvent in food/feed sample preparation (carryover and residue verification).
— Cleaning/disinfection in laboratories and manufacturing (air and surface monitoring).
— Component in coatings, inks, and electronics manufacturing (VOC compliance testing).
Regulatory Compliance and Guidelines
— Pharmaceuticals: Propanol is commonly classified as a Class 3 residual solvent per ICH Q3C, with generally low toxic potential; routine testing ensures limits in drug substances and products are met.
— Workplace exposure: Occupational exposure limits are established by agencies such as OSHA/ACGIH (region-specific). Employers must implement exposure monitoring and controls.
— Environmental and air: VOC monitoring frameworks (e.g., EPA/EU methods) regulate emissions and ambient concentrations. Local/national requirements apply for industrial sources and indoor air quality.
Monitoring and Target Matrices
— Pharmaceuticals: Drug substance/product residual solvent testing; cleaning validation rinses and swabs.
— Food and consumer goods: Solvent residues in extracts, flavorings, food-contact materials; packaging off-odor investigations.
— Environmental: Ambient/indoor air VOCs, stack emissions, wastewater and surface water screening.
— Occupational hygiene: Personal and area air sampling in production and laboratories.
Analytical Methods
— Headspace GC-FID/GC-MS for residual solvent quantification in pharmaceuticals and solid/liquid matrices (USP/Ph. Eur.-aligned approaches).
— Purge-and-trap GC-MS for water and wastewater VOCs (commonly aligned with EPA 524/624/8260-type methodologies).
— Thermal desorption GC-MS for air monitoring, including sorbent tube sampling and TO-15/TO-17-type workflows (canister or sorbent-based).
— Direct injection GC for higher-concentration process samples; SPME as an alternative for challenging matrices.
Method Validation and QA/QC
Establish calibration across the expected range using matrix-matched or headspace conditions; assess linearity, LOD/LOQ, precision, trueness, recovery, carryover, headspace partitioning stability, and potential isomer coelution.
Use internal standards (e.g., stable isotope-labelled analogs where applicable) for improved accuracy and compensation of volatilization or matrix effects.
Include routine system suitability checks, continuing calibration verification, blanks, and spiked controls with traceable reference materials.
Health Impact (Human Toxicity)
Both 1-propanol and 2-propanol can cause eye and respiratory irritation and CNS depression at elevated exposures. Ingestion or significant inhalation may lead to dizziness, headache, nausea, or in severe cases, unconsciousness. 1-Propanol is metabolized to propionaldehyde/propionic acid; 2-propanol to acetone. Proper ventilation, exposure controls, and PPE reduce risks.
Environmental Impact
— Fate: Readily biodegradable, high volatility, low bioaccumulation potential. Rapid atmospheric degradation via hydroxyl radicals.
— Aquatic toxicity: Generally low to moderate acute toxicity; avoid uncontrolled releases to water systems. Implement appropriate containment and waste management.
Effects on Wildlife
Acute exposure to elevated vapor or aqueous concentrations may cause transient behavioral or respiratory effects. Chronic bioaccumulation is unlikely; risk is primarily associated with spills and localized high concentrations.
Safety Measures and Handling
GHS classification typically includes: Highly flammable liquid and vapor; causes serious eye irritation; may cause drowsiness or dizziness. Implement explosion-proof ventilation, eliminate ignition sources, ground/bond containers, and use appropriate PPE (safety glasses, gloves, lab coat). Store in tightly closed containers away from heat/oxidizers. Use flame-resistant refrigerators for flammable liquids where applicable.
Analytical Reference Materials From HPC Standards
— Neat propanol reference materials (1-propanol, 2-propanol) with defined purity and characterization for calibration and spiking.
— Ready-to-use certified solutions at multiple concentration levels for headspace GC and GC-MS calibration.
— Optional stable isotope-labelled internal standards to enhance quantitation accuracy.
All reference materials are produced under stringent quality systems with full documentation, uncertainty estimates, and traceability to international units where applicable, supporting ISO 17025/17034-compliant workflows.
Storage and Stability
Store at controlled room temperature or refrigerated as specified on the certificate. Protect from light and ignition sources. Minimize headspace and repeated opening to reduce evaporative loss. Observe labeled shelf life and expiry; monitor for composition changes in multi-component mixtures.
Documentation and Traceability
Each reference material is supplied with a Certificate of Analysis detailing identity, lot number, gravimetric preparation, purity data, concentration, expanded uncertainty, intended use, storage conditions, and safety information. Batch-specific documentation supports audit and regulatory submissions.
Industries Served
Pharmaceutical and biopharma, contract testing laboratories, food and flavor analysis, environmental and industrial hygiene labs, chemical manufacturing, coatings and electronics production.
Ordering and Customization
Standard pack sizes and concentrations are available for rapid dispatch. Custom mixtures, matrix-matched solutions, and bespoke concentrations can be prepared on request to align with method-specific calibration ranges and regulatory requirements.