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Propyl-2-thiouracil (6-Propyl-2-thiouracil, Propylthiouracil, PTU)
Propyl-2-thiouracil High-Purity Reference Materials for Confident Compliance
Ensure traceable, matrix-robust quantification of Propyl-2-thiouracil across wastewater, surface water, groundwater, and food studies with HPC Standards GmbH. As a manufacturer of certified reference materials, we deliver neat substances, ready-to-use LC solutions, and stable isotopelabelled analogues for precise calibration, ISOIEC 17025-aligned validation, and routine QC. Benefit from documented purity, uncertainty, and batch consistencybacked by global supply and expert technical supportto drive reliable results and meet regulatory requirements with confidence.
Product | Catalog No./ CAS No. | Quantity | Price | |
|---|---|---|---|---|
 | 679741 | 1X10MG | Please log in. | |
ISO 17034 Certified Reference Material 13C,15N2-6-Propyl-2-thiouracil solution |  | 693042 | 1X1ML | Please log in. |
 | 676310 | 1X250MG | Please log in. | |
ISO 17034 Certified Reference Material 6-Propyl-2-thiouracil solution |  | 693956 | 1X1ML | Please log in. |
High-quality reference materials for precise determination of Propyl-2-thiouracil in food, environmental, and wastewater matrices to support regulatory compliance, method validation, and routine monitoring.
Overview
Propyl-2-thiouracil (commonly known as Propylthiouracil, PTU; synonym: 6-propyl-2-thiouracil) is a thioamide compound used as an antithyroid agent. In analytical contexts, PTU is monitored as a pharmaceutical residue and as a taste/odor modifier in sensory science. Reliable quantification requires matrix-robust calibration and traceable reference materials.
HPC Standards GmbH provides validated reference materials for PTU to ensure accurate identification, quantification, and method performance verification across a range of analytical platforms.
Uses
- Active pharmaceutical ingredient (API) in antithyroid therapy for hyperthyroidism (human medicine).
- Analytical target in environmental monitoring programs for pharmaceutical residues (e.g., wastewater, surface water) and, where relevant, in food matrices potentially impacted by contamination.
- Sensory research marker due to its pronounced bitter/thiourea-associated taste characteristics (not for human consumption in routine lab work).
Regulatory Context
- PTU may fall under general regulations for pharmaceuticals in the environment and under water quality monitoring frameworks at national or regional levels.
- Laboratories should align reporting limits and quality control with applicable guidance (e.g., water monitoring directives, pharmaceutical residue surveillance, method validation standards such as ISO/IEC 17025).
- Always verify jurisdiction-specific requirements for target analytes, reporting thresholds, and data quality objectives.
Monitoring and Target Matrices
- Wastewater influent/effluent, sludge, surface water, groundwater.
- Drinking water (screening studies), industrial discharges.
- Food and feed matrices in contamination studies where pharmaceutical residues are of concern.
Health Impact
- PTU is pharmacologically active: it inhibits thyroid hormone synthesis and peripheral conversion of thyroxine (T4) to triiodothyronine (T3).
- Human toxicity (clinical context): known risks include hepatotoxicity and hematological adverse effects; laboratory exposure should be minimized and controlled.
- Occupational exposure in analytical laboratories should be prevented through appropriate engineering controls and PPE.
Environmental Impact
- As a biologically active molecule, PTU can persist through municipal wastewater streams depending on treatment efficacy.
- Potential ecological relevance due to endocrine-modulating activity warrants sensitive detection and trend monitoring in aquatic environments.
Analytical Considerations
- Common techniques: LC-UV/LC-DAD, LC-MS/MS, LC-HRMS.
- Sample preparation: solid-phase extraction (SPE) for aqueous matrices; QuEChERS/SPE hybrids for complex food or sludge; filtration and matrix-matched calibration recommended.
- Performance parameters: method validation should address recovery, matrix effects, procedural blanks, LOD/LOQ, linearity, repeatability/reproducibility, and measurement uncertainty.
Method Development Tips
- Employ isotopically labeled internal standards for PTU to correct matrix effects and recovery variability.
- Optimize chromatographic conditions for polar thioamide chemistries; consider acidic mobile phases to improve peak shape and retention.
- Verify selectivity against structural analogs (e.g., thiouracil derivatives) to avoid false positives in HRMS suspect screening.
Quality Control
- Use certified reference materials for calibration curves and independent QC checks (low/mid/high levels).
- Apply bracketing calibration for LC-MS/MS sequences and include matrix spikes to assess ongoing recovery.
- Store solutions under recommended conditions (light-protected, controlled temperature) and monitor stability by periodic checks.
Safety Measures
- Handle PTU as a potentially hazardous pharmaceutical compound: wear lab coat, nitrile gloves, and safety glasses; work in a fume hood when preparing standards.
- Avoid inhalation/ingestion and skin contact; prevent cross-contamination of work areas and instruments.
- Dispose of PTU-containing waste according to local regulations for pharmaceutical/chemical residues.
Storage and Stability
- Store neat materials in tightly closed containers, protected from light and moisture, at recommended temperatures.
- Prepare calibration solutions with high-purity solvents; document preparation, lot numbers, and expiry dates.
- Assess solution stability under intended storage conditions; use fresh working solutions for trace-level analysis.
HPC Standards Reference Materials
- Matrix: neat material and ready-to-use solutions in suitable solvents and concentrations for LC-based methods.
- Availability of stable isotope-labeled derivatives to support isotope-dilution quantification and enhanced accuracy.
- Supplied with detailed documentation: certificate of analysis, traceability, purity profile, uncertainty, and recommended storage.
Applications in Food and Environmental Analysis
- Trace quantification in wastewater and surface waters for pharmaceutical residue surveillance.
- Screening and confirmation workflows in environmental labs using targeted LC-MS/MS and non-target HRMS.
- Contamination studies in relevant food matrices where pharmaceutical residues may be investigated.
Compliance and Accreditation Support
- Reference materials support ISO/IEC 17025-compliant validation, proficiency testing, and routine QC.
- Batch-to-batch consistency enables long-term comparability of results across studies and sites.
Ordering Information
- Product formats: neat reference materials, single-analyte solutions, multi-analyte mixes, and isotope-labeled internal standards.
- Custom concentrations, solvents, and packaging available on request to match your method requirements.
- Global shipping with temperature and light protection; technical support from our application specialists.
Synonyms and Identifiers
- Synonyms: Propylthiouracil; 6-Propyl-2-thiouracil; PTU.
- Chemical class: Thioamide; thiouracil derivative.
- Typical analyte category: pharmaceutical residue / antithyroid agent.
Why HPC Standards
- Manufacturer expertise in reference materials for pharmaceuticals, pesticides, veterinary products, metabolites, and isotope-labeled analogues.
- Products tested against international quality requirements and designed to meet the highest industrial standards.
- Reliable supply, comprehensive documentation, and expert technical support for confident, compliant analysis.